Search Results - "Alvaro Villarroel"

Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade by Revuelta, Miren, Urrutia, Janire, Villarroel, Alvaro, Casis, Oscar

“…Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during Alzheimer’s Disease (AD) due to the imbalance in the production vs…”
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Atomistic Insights of Calmodulin Gating of Complete Ion Channels by Núñez, Eider, Muguruza-Montero, Arantza, Villarroel, Alvaro

“…Intracellular calcium is essential for many physiological processes, from neuronal signaling and exocytosis to muscle contraction and bone formation. Ca…”
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Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K⁺ channel by Bernardo-Seisdedos, Ganeko, Nuñez, Eider, Gomis-Perez, Carolina, Malo, Covadonga, Villarroel, Álvaro, Millet, Oscar

“…The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K⁺ M-current, a key controller of neuronal…”
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Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel by Ramis, Rafael, Ballesteros, Óscar R., Muguruza-Montero, Arantza, M-Alicante, Sara, Núñez, Eider, Villarroel, Álvaro, Leonardo, Aritz, Bergara, Aitor

“…The family of small-conductance Ca2+-activated potassium ion channels (SK channels) is composed of four members (SK1, SK2, SK3, and SK4) involved in…”
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Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions by Alaimo, Alessandro, Villarroel, Alvaro

“…The ubiquitous calcium transducer calmodulin (CaM) plays a pivotal role in many cellular processes, regulating a myriad of structurally different target…”
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The Crossroad of Ion Channels and Calmodulin in Disease by Urrutia, Janire, Aguado, Alejandra, Muguruza-Montero, Arantza, Núñez, Eider, Malo, Covadonga, Casis, Oscar, Villarroel, Alvaro

“…Calmodulin (CaM) is the principal Ca sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the…”
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The ever changing moods of calmodulin: how structural plasticity entails transductional adaptability by Villarroel, Alvaro, Taglialatela, Maurizio, Bernardo-Seisdedos, Ganeko, Alaimo, Alessandro, Agirre, Jon, Alberdi, Araitz, Gomis-Perez, Carolina, Soldovieri, Maria Virginia, Ambrosino, Paolo, Malo, Covadonga, Areso, Pilar

“…The exceptional versatility of calmodulin (CaM) three-dimensional arrangement is reflected in the growing number of structural models of CaM/protein complexes…”
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Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors by Alaimo, Alessandro, Lorenzoni, Marco, Ambrosino, Paolo, Bertossi, Arianna, Bisio, Alessandra, Macchia, Alice, Zoni, Eugenio, Genovesi, Sacha, Cambuli, Francesco, Foletto, Veronica, De Felice, Dario, Soldovieri, Maria Virginia, Mosca, Ilaria, Gandolfi, Francesco, Brunelli, Matteo, Petris, Gianluca, Cereseto, Anna, Villarroel, Alvaro, Thalmann, George, Carbone, Francesco Giuseppe, Kruithof-de Julio, Marianna, Barbareschi, Mattia, Romanel, Alessandro, Taglialatela, Maurizio, Lunardi, Andrea

“…Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic…”
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MLe-KCNQ2: An Artificial Intelligence Model for the Prognosis of Missense KCNQ2 Gene Variants by Saez-Matia, Alba, Ibarluzea, Markel G, M-Alicante, Sara, Muguruza-Montero, Arantza, Nuñez, Eider, Ramis, Rafael, Ballesteros, Oscar R, Lasa-Goicuria, Diego, Fons, Carmen, Gallego, Mónica, Casis, Oscar, Leonardo, Aritz, Bergara, Aitor, Villarroel, Alvaro

“…Despite the increasing availability of genomic data and enhanced data analysis procedures, predicting the severity of associated diseases remains elusive in…”
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Redox regulation of KV7 channels through EF3 hand of calmodulin by Nuñez, Eider, Jones, Frederick, Muguruza-Montero, Arantza, Urrutia, Janire, Aguado, Alejandra, Malo, Covadonga, Bernardo-Seisdedos, Ganeko, Domene, Carmen, Millet, Oscar, Gamper, Nikita, Villarroel, Alvaro

“…Neuronal K V 7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the…”
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Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy by Baltasar-Marchueta, Maider, Llona, Leire, M-Alicante, Sara, Barbolla, Iratxe, Ibarluzea, Markel Garcia, Ramis, Rafael, Salomon, Ane Miren, Fundora, Brenda, Araujo, Ariane, Muguruza-Montero, Arantza, Nuñez, Eider, Pérez-Olea, Scarlett, Villanueva, Christian, Leonardo, Aritz, Arrasate, Sonia, Sotomayor, Nuria, Villarroel, Alvaro, Bergara, Aitor, Lete, Esther, González-Díaz, Humberto

“…The development of new molecules for the treatment of calmodulin related cardiovascular or neurodegenerative diseases is an interesting goal. In this work, we…”
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An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel by Urrutia, Janire, Aguado, Alejandra, Gomis-Perez, Carolina, Muguruza-Montero, Arantza, Ballesteros, Oscar R, Zhang, Jiaren, Nuñez, Eider, Malo, Covadonga, Chung, Hee Jung, Leonardo, Aritz, Bergara, Aitor, Villarroel, Alvaro

“…The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of…”
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Fluorometric Measurement of Calmodulin-Dependent Peptide-Protein Interactions Using Dansylated Calmodulin by Nuñez, Eider, Muguruza-Montero, Arantza, Alicante, Sara M, Villarroel, Alvaro

“…The assessment of peptide-protein interactions is a pivotal aspect of studying the functionality and mechanisms of various bioactive peptides. In this context,…”
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Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome by Lazo, Pedro A, García, Juan L, Gómez-Puertas, Paulino, Marcos-Alcalde, Íñigo, Arjona, Cesar, Villarroel, Alvaro, González-Sarmiento, Rogelio, Fons, Carmen

“…Complex neurodevelopmental syndromes frequently have an unknown etiology, in which genetic factors play a pathogenic role. This study utilizes whole-exome…”
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Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex by Alaimo, Alessandro, Alberdi, Araitz, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Bernardo-Seisdedos, Ganeko, Malo, Covadonga, Millet, Oscar, Areso, Pilar, Villarroel, Alvaro

“…Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds…”
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Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin by Gomis-Perez, Carolina, Soldovieri, Maria V., Malo, Covadonga, Ambrosino, Paolo, Taglialatela, Maurizio, Areso, Pilar, Villarroel, Alvaro

“…The identification and understanding of critical factors regulating M-current functional density, whose main components are Kv7.2 and Kv7.3 subunits, has…”
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Calmodulin Activation Limits the Rate of KCNQ2 K+ Channel Exit from the Endoplasmic Reticulum by Alaimo, Alessandro, Gómez-Posada, Juan Camilo, Aivar, Paloma, Etxeberría, Ainhoa, Rodriguez-Alfaro, Jose Angel, Areso, Pilar, Villarroel, Alvaro

“…The potential regulation of protein trafficking by calmodulin (CaM) is a novel concept that remains to be substantiated. We proposed that KCNQ2 K+ channel…”
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The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current by Miranda, Pablo, Cadaveira-Mosquera, Alba, González-Montelongo, Rafaela, Villarroel, Alvaro, González-Hernández, Tomás, Lamas, J Antonio, Alvarez de la Rosa, Diego, Giraldez, Teresa

“…The M-current formed by tetramerization of Kv7.2 and Kv7.3 subunits is a neuronal voltage-gated K(+) conductance that controls resting membrane potential and…”
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Kv7 channels can function without constitutive calmodulin tethering by Gómez-Posada, Juan Camilo, Aivar, Paloma, Alberdi, Araitz, Alaimo, Alessandro, Etxeberría, Ainhoa, Fernández-Orth, Juncal, Zamalloa, Teresa, Roura-Ferrer, Meritxell, Villace, Patricia, Areso, Pilar, Casis, Oscar, Villarroel, Alvaro

“…M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding…”
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The Identification and Characterization of a Noncontinuous Calmodulin-binding Site in Noninactivating Voltage-dependent KCNQ Potassium Channels by Yus-Najera, Eva, Santana-Castro, Irene, Villarroel, Alvaro

“…We show here that in a yeast two-hybrid assay calmodulin (CaM) interacts with the intracellular C-terminal region of several members of the KCNQ family of…”
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