The role of diffusion-weighted imaging in the evaluation of meningiomas: radio-pathologic correlation

To study the behavior of meningiomas in diffusion-weighted sequences and the correlation of these findings with the histological findings. We prospectively included all patients operated on for meningiomas at our hospital during two years. We studied 30 meningiomas in 28 patients aged 31 to 85 years...

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Bibliographic Details
Published in:	Radiología Vol. 51; no. 4; p. 411
Main Authors:	Cabada, T, Caballero, M C, Insausti, I, Alvarez de Eulate, N, Bacaicoa, C, Zazpe, I, Tuñón, T
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-07-2009
Subjects:	Adult Aged Aged, 80 and over Diffusion Magnetic Resonance Imaging Female Humans Male Meningeal Neoplasms - diagnostic imaging Meningeal Neoplasms - pathology Meningioma - diagnostic imaging Meningioma - pathology Middle Aged Prospective Studies Radiography
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Summary:	To study the behavior of meningiomas in diffusion-weighted sequences and the correlation of these findings with the histological findings. We prospectively included all patients operated on for meningiomas at our hospital during two years. We studied 30 meningiomas in 28 patients aged 31 to 85 years old. All patients underwent MRI prior to surgery, including diffusion-weighted sequences, in a 1.5 T scanner. We evaluated the signal intensity in T2-weighted images, diffusion-weighted images (b=1,000), and apparent diffusion coefficient (ADC) maps within the tumor and in the parietal white matter as a reference. In the histological study, cellularity, proliferation index, histological grade, and cerebral invasion were evaluated. Of the 30 meningiomas, 22 were World Health Organization (WHO) grade I and 8 were atypical or WHO grade II. The overall mean value of the ADC was 89.19+/-13.95x10(-3) mm2/s; the mean ADC value was 82+/-13.69x10(-3) mm2/s in the atypical group and 92.21+/-13.21x10(-3) mm2/s in the typical group. No statistically significant differences were found between the 2 groups. Two subtypes of typical meningiomas, secretory and angiomatous meningiomas, had the highest values in the ADC maps. In the histological analysis, there was a significant association between tumor cellularity and the signal in the ADC map. Meningiomas show moderately restricted diffusion. The signal on the ADC map is associated with tumor cellularity but we have not demonstrated its usefulness for predicting the histological grade.
ISSN:	0033-8338
DOI:	10.1016/j.rx.2009.01.017