Search Results - "Alvarez Abreu, Paula"

Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na + , K + ATPase by Souza, Kauê Francisco Corrêa de Souza E, Rabelo, Vitor Won-Held, Abreu, Paula Alvarez, Santos, Cláudio César Cirne, Amaral E Silva, Nayane Abreu do, Luna, Daniela de, Ferreira, Vitor Francisco, Braz, Bernardo Ferreira, Santelli, Ricardo Erthal, Gonçalves-de-Albuquerque, Cassiano Felippe, Paixão, Izabel Christina Nunes de Palmer, Burth, Patricia

“…Since 1970 acyclovir (ACV) has been the reference drug in treating herpes simplex virus (HSV) infections. However, resistant herpes simplex virus type 1…”
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Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells by Costa, Dora C.S., de Almeida, Gabriella Silva, Rabelo, Vitor Won-Held, Cabral, Lucio Mendes, Sathler, Plínio Cunha, Alvarez Abreu, Paula, Ferreira, Vitor Francisco, Cláudio Rodrigues Pereira da Silva, Luiz, da Silva, Fernando de C.

“…Naphthoquinones and 1,2,3-triazoles are structural pharmacophore that is known to impart several cancer cells. This work shows a synthetic methodology to…”
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Pro-Apoptotic Antitumoral Effect of Novel Acridine-Core Naphthoquinone Compounds against Oral Squamous Cell Carcinoma by Zorzanelli, Bruna Costa, Ouverney, Gabriel, Pauli, Fernanda P, da Fonseca, Anna Carolina Carvalho, de Almeida, Elan Cardozo Paes, de Carvalho, Danielle Gonçalves, Possik, Patricia Abrão, Rabelo, Vitor Won-Held, Abreu, Paula Alvarez, Pontes, Bruno, Ferreira, Vitor Francisco, Forezi, Luana da Silva Magalhães, da Silva, Fernando de Carvalho, Robbs, Bruno Kaufmann

“…Oral squamous cell carcinoma (OSCC) is a global public health problem with high incidence and mortality. The chemotherapeutic agents used in the clinic, alone…”
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Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma by Cavalcanti Chipoline, Ingrid, Carolina Carvalho da Fonseca, Anna, Ribeiro Machado da Costa, Gabriella, Pereira de Souza, Michele, Won-Held Rabelo, Vitor, de Queiroz, Lucas N., Luiz Ferraz de Souza, Theo, Cardozo Paes de Almeida, Elan, Alvarez Abreu, Paula, Pontes, Bruno, Francisco Ferreira, Vitor, de Carvalho da Silva, Fernando, Robbs, Bruno K.

“…[Display omitted] •Thirty-five new compounds of triazole naphthoquinones were synthesized.•Compounds 16a, 16b and 16 g were able to induce cytotoxicity in…”
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Chloroquinolone Carboxamide Derivatives as New Anti-HSV-1 Promising Drugs by Souza, Mariana, de Melo, Camilly Pestana Pires, Faro, Letícia Villafranca, Fragel-Madeira, Luciane, Giongo, Viveca, Abreu, Paula Alvarez, da Costa Santos Boechat, Fernanda, de Oliveira Silva, David, de Carvalho Tolentino, Nathalia Motta, Cirne-Santos, Claudio Cesar, de Souza Barros, Caroline, Castro, Helena Carla, de Souza, Marcos Costa, de Souza, Maria Cecília Bastos Vieira, de Palmer Paixão, Izabel Christina Nunes

“…Since the emergence of HSV resistant strains, new antiviral agents have emerged and still are urgently needed, especially those with alternative targets. In…”
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Marine Diterpenes: Molecular Modeling of Thrombin Inhibitors with Potential Biotechnological Application as an Antithrombotic by Pereira, Rebeca Cristina Costa, Lourenço, André Luiz, Terra, Luciana, Abreu, Paula Alvarez, Laneuville Teixeira, Valéria, Castro, Helena Carla

“…Thrombosis related diseases are among the main causes of death and incapacity in the world. Despite the existence of antithrombotic agents available for…”
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Computational strategy for visualizing structures and teaching biochemistry by Abreu, Paula Alvarez, Carvalho, Karina de Lima, Rabelo, Vitor Won‐Held, Castro, Helena Carla

“…Computational techniques have great potential to improve the teaching‐learning. In this work, we used a computational strategy to visualize three‐dimensional…”
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Antileishmanial Thioureas: Synthesis, Biological Activity and in Silico Evaluations of New Promising Derivatives by Viana, Gil Mendes, Soares, Deivid Costa, Santana, Marcos Vinicius, Amaral, Lilian Henriques do, Meireles, Paloma Wetler, Nunes, Raquel Pinto, Luiz Cláudio Rodrigues Pereira da Silva, Lúcia Cruz de Sequeira Aguiar, Rodrigues, Carlos Rangel, Sousa, Valeria Pereira de, Castro, Helena Carla, Abreu, Paula Alvarez, Sathler, Plínio Cunha, Saraiva, Elvira Maria, Cabral, Lucio Mendes

“…Leishmaniasis is a neglected tropical disease caused by protozoan parasites belonging to the genus Leishmania. Currently, the drugs available for treatment of…”
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Anticancer Activity and Molecular Targets of Piper cernuum Substances in Oral Squamous Cell Carcinoma Models by Machado, Thaíssa Queiróz, Lima, Maria Emanuelle Damazio, da Silva, Rafael Carriello, Macedo, Arthur Ladeira, de Queiroz, Lucas Nicolau, Angrisani, Bianca Roberta Peres, da Fonseca, Anna Carolina Carvalho, Câmara, Priscilla Rodrigues, Rabelo, Vitor Von-Held, Carollo, Carlos Alexandre, de Lima Moreira, Davyson, de Almeida, Elan Cardozo Paes, Vasconcelos, Thatyana Rocha Alves, Abreu, Paula Alvarez, Valverde, Alessandra Leda, Robbs, Bruno Kaufmann

“…Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, with high morbidity and mortality rates. The development of new drugs to treat OSCC…”
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Structure–function inferences based on molecular modeling, sequence-based methods and biological data analysis of snake venom lectins by Abreu, Paula Alvarez, Albuquerque, Magaly Girão, Rodrigues, Carlos Rangel, Castro, Helena Carla

“…Lectins are a structurally and functionally diverse group of proteins from different sources, capable to recognize and bind specifically carbohydrates. Several…”
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O movimento antivacina no YouTube nos tempos de pós-verdade: Educação em saúde ou desinformação? by Da Costa, Bianca Barros, Viegas, Daiane de Jesus, Moreira, Thamyris Almeida, Abreu, Paula Alvarez

“…Apesar dos benefícios da vacinação, movimentos antivacinação têm se espalhado pelo  mundo. Neste estudo foi feita uma análise dos vídeos sobre o movimento…”
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Snake Venom: Any Clue for Antibiotics and CAM? by de Lima, Deivy Clementino, Alvarez Abreu, Paula, de Freitas, Cícero Carlos, Santos, Dilvani Oliveira, Borges, Rodrigo Oliveira, Dos Santos, Tereza Cristina, Mendes Cabral, Lúcio, Rodrigues, Carlos R, Castro, Helena Carla

“…Lately several naturally occurring peptides presenting antimicrobial activity have been described in the literature. However, snake venoms, which are an…”
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Identification and characterization of a new member of snake venom thrombin inhibitors from Bothrops insularis using a proteomic approach by Oliveira-Carvalho, Ana Lúcia, Guimarães, Patrícia Ramos, Abreu, Paula Alvarez, Dutra, Denis L.S., Junqueira-de-Azevedo, Inácio L.M., Rodrigues, Carlos Rangel, Ho, Paulo Lee, Castro, Helena C., Zingali, Russolina B.

“…Snake venom C-type lectin-like proteins (CLPs) are ubiquitously found in Viperidae snake venoms and differ from the C-type lectins as they display different…”
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Spider’s Silk as a Potential Source of Antibiotics: An Integrative Review by Schwenck, Lucas da Costa, Abreu, Paula Alvarez, Nunes-da-Fonseca, Rodrigo

“…Spiders produce webs, which are still a largely unexplored source of antibacterial compounds, although the reports of its application in the medical field…”
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Design strategies of oxidosqualene cyclase inhibitors: Targeting the sterol biosynthetic pathway by Rabelo, Vitor Won-Held, Romeiro, Nelilma Correia, Abreu, Paula Alvarez

“…•Targeting sterol biosynthesis pathway is an attractive strategy for drug discovery.•Many oxidosqualene cyclase (OSC) inhibitors were designed based on the…”
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Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase by Rabelo, Vitor Won-Held, Viegas, Daiane de Jesus, Tucci, Erline Machado Neves, Romeiro, Nelilma Correia, Abreu, Paula Alvarez

“…[Display omitted] •We identified potential oxidosqualene cyclase inhibitors by virtual screening.•This enzyme is an important target for antimicrobials,…”
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Class A β-lactamases and inhibitors: In silico analysis of the binding mode and the relationship with resistance by Pereira, Rebeca, Rabelo, Vitor Won-Held, Sibajev, Alexander, Abreu, Paula Alvarez, Castro, Helena Carla

“…•Class A β-lactamases and their classical inhibitor were evaluated.•The overall 3D structure and active site are highly conserved among these…”
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Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach by Rabelo, Vitor Won-Held, Romeiro, Nelilma Correia, Paixão, Izabel Christina Nunes de Palmer, Abreu, Paula Alvarez

“…Herpes simplex virus type 1 (HSV-1) infections affect about two-thirds of the world population, and the standard treatment consists of acyclovir (ACV) and its…”
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Structural insights into the inhibition of the nsP2 protease from Chikungunya virus by molecular modeling approaches by Rabelo, Vitor Won-Held, de Palmer Paixão, Izabel Christina Nunes, Abreu, Paula Alvarez

“…Chikungunya virus (CHIKV) is the etiological agent of the Chikungunya fever which has spread worldwide. Clinically, this disease may lead to prolonged…”
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Targeting Chikungunya virus by computational approaches: from viral biology to the development of therapeutic strategies by Rabelo, Vitor Won-Held, Paixão, Izabel Christina Nunes de Palmer, Abreu, Paula Alvarez

“…: Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, a reemerging infectious disease. This disease can cause severe manifestations that…”
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