Search Results - "Alvarez‐Baron, Elena"

The burden of epilepsy and unmet need in people with focal seizures by Ioannou, Persefoni, Foster, Daniella L., Sander, Josemir W., Dupont, Sophie, Gil‐Nagel, Antonio, Drogon O'Flaherty, Ewa, Alvarez‐Baron, Elena, Medjedovic, Jasmina

“…Background Epilepsy is one of the most common neurological conditions worldwide. As a chronic condition, epilepsy imposes a significant burden on people with…”
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Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain by Mittelsteadt, Tobias, Seifert, Gerald, Alvárez-Barón, Elena, Steinhäuser, Christian, Becker, Albert J., Schoch, Susanne

“…Synaptotagmins are a large family of membrane‐trafficking proteins. They are evolutionarily conserved and have 15 members in rodents and humans…”
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Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis by Alvarez-Barón, Elena, Bien, Christian G, Schramm, Johannes, Elger, Christian E, Becker, Albert J, Schoch, Susanne

“…Summary Rasmussen encephalitis (RE) is a rare form of severe unihemispheric epilepsy established to be an autoimmune disease. Here we demonstrate the presence…”
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RIM proteins and their role in synapse function by Mittelstaedt, Tobias, Alvaréz-Baron, Elena, Schoch, Susanne

“…Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The…”
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147  Long-term cenobamate retention in people with focal onset seizures: pooled data from open-label studies by Sander, Josemir W, Alvarez-Baron, Elena, Finlan, Lee, Toledo, Manuel

“…PurposeMost people with epilepsy receive chronic, long-term treatment with ≥1 anti-seizure medication. Retention rates provide can act as a proxy measure for…”
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157  Efficacy of adjunctive cenobamate: post-hoc analysis in patients grouped by concomitant anti-epileptic drug type by Brandt, Christian, Serratosa, Jose, Sanchez-Alvarez, Juan, Alvarez-Baron, Elena, Finlan, Lee, Milanov, Ivan, Steinhoff, Bernhard J

“…PurposeThere has been little success with polytherapy for patients with drug-resistant epilepsy. The need for optimizing AED combinations is high. Cenobamate…”
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163  Long-term safety of adjunctive cenobamate in patients with uncontrolled focal seizures by Morales, Irene Garcia, Brodie, Martin J, Milanov, Ivan, Czlonkowska, Anna, Brandt, Christian, lan, Lee Fin, Alvarez-Baron, Elena, Steinhoff, Bernhard J

“…PurposeResults from two double-blind, placebo-controlled studies demonstrated that adjunctive ceno- bamate significantly reduced the frequency of seizures vs…”
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Mapping analysis to predict SF-6D utilities from health outcomes in people with focal epilepsy by Flint, India, Medjedovic, Jasmina, Drogon O’Flaherty, Ewa, Alvarez-Baron, Elena, Thangavelu, Karthinathan, Savic, Natasa, Meunier, Aurelie, Longworth, Louise

“…Background Focal-onset seizures (FOS) are commonly experienced by people with epilepsy and have a significant impact on quality of life (QoL). This study aimed…”
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Cénobamate, un nouveau médicament anti-épileptique doté d’un double mécanisme d’action unique et complémentaire by Alvarez-Baron, Elena, Lothe, Amelie, Lombardo, Ilise

“…Le cénobamate est un nouveau médicament anti-épileptique récemment approuvé par la FDA. Or, jusqu’à présent, son mécanisme d’action n’a été décrit que…”
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RIM3γ and RIM4γ are key regulators of neuronal arborization by Alvarez-Baron, Elena, Michel, Katrin, Mittelstaedt, Tobias, Opitz, Thoralf, Schmitz, Frank, Beck, Heinz, Dietrich, Dirk, Becker, Albert J, Schoch, Susanne

“…The large isoforms of the Rab3 interacting molecule (RIM) family, RIM1α/β and RIM2α/β, have been shown to be centrally involved in mediating presynaptic active…”
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Identifying key unmet needs and value drivers in the treatment of focal-onset seizures (FOS) in patients with drug-resistant epilepsy (DRE) in Spain through Multi-Criteria Decision Analysis (MCDA) by Villanueva, Vicente, Carreño, Mar, Gil-Nagel, Antonio, Serrano-Castro, Pedro Jesús, Serratosa, José María, Toledo, Manuel, Álvarez-Barón, Elena, Gil, Alicia, Subías-Labazuy, Silvia

“…•Drug-resistant epilepsy is considered a severe condition.•Drug-resistant epilepsy affects approximately 40% of epileptic patients.•Drug-resistant epilepsy…”
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Number needed to treat and associated cost analysis of cenobamate versus third-generation anti-seizure medications for the treatment of focal-onset seizures in patients with drug-resistant epilepsy in Spain by Villanueva, Vicente, Serratosa, José M., Toledo, Manuel, Ángel Calleja, Miguel, Navarro, Andrés, Sabaniego, Joel, Pérez-Domper, Paloma, Álvarez-Barón, Elena, Subías, Silvia, Gil, Alicia

“…•Cenobamate represents the most efficacy ASM vs third-generation ASMs.•Cenobamate at DDD represents the most efficient ASM vs third-generation…”
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Value contribution of cenobamate for the treatment of Focal-Onset Seizures (FOS) in patients with drug-resistant epilepsy (DRE) in Spain through reflective Multi-Criteria Decision Analysis (MCDA) by Falip, Mercè, López González, Francisco Javier, Martín-Herranz, Isabel, Merino-Bohórquez, Vicente, Montoya, Javier, Rey Gómez-Serranillos, Isabel, Rodriguez Uranga, Juan Jesús, Ruiz, Elías, Sancho-López, Aranzazu, Trillo Mata, Jose Luis, Antoni Vallès, Joan, Álvarez-Barón, Elena, Sabaniego, Joel, Subías-Labazuy, Silvia, Gil, Alicia

“…•Drug-resistant epilepsy (DRE) is considered a severe condition.•DRE is associated with important burden for patients and the healthcare system.•Cenobamate…”
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The specific anti-hostility effect of lurasidone in patients with an acute exacerbation of schizophrenia: results of pooled post hoc analyses in adolescents and adults by Citrome, Leslie, Álvarez-Barón, Elena, Gabarda-Inat, Irene, Thangavelu, Karthinathan, Tocco, Michael

“…Symptoms of hostility in patients during acute exacerbations of schizophrenia have been associated with aggressive behavior. Data suggest that some…”
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