Search Results - "Alvarez, Vanina"

Antibodies to variable surface antigens induce antigenic variation in the intestinal parasite Giardia lamblia by Tenaglia, Albano H., Luján, Lucas A., Ríos, Diego N., Molina, Cecilia R., Midlej, Victor, Iribarren, Paula A., Berazategui, María A., Torri, Alessandro, Saura, Alicia, Peralta, Damián O., Rodríguez-Walker, Macarena, Fernández, Elmer A., Petiti, Juan P., Serradell, Marianela C., Gargantini, Pablo R., Sparwasser, Tim, Alvarez, Vanina E., de Souza, Wanderley, Luján, Hugo D.

“…The genomes of most protozoa encode families of variant surface antigens. In some parasitic microorganisms, it has been demonstrated that mutually exclusive…”
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The peptidases of Trypanosoma cruzi: Digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death by Alvarez, Vanina E., Niemirowicz, Gabriela T., Cazzulo, Juan J.

“…Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains cysteine, serine, threonine, aspartyl and metallo peptidases. The most…”
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Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes by Salas-Sarduy, Emir, Landaburu, Lionel Urán, Carmona, Adriana K, Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina E, Niemirowicz, Gabriela T

“…Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including…”
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Autophagy Is Involved in Nutritional Stress Response and Differentiation in Trypanosoma cruzi by Alvarez, Vanina E., Kosec, Gregor, Sant'Anna, Celso, Turk, Vito, Cazzulo, Juan J., Turk, Boris

“…Autophagy is the major mechanism used by eukaryotic cells to degrade and recycle proteins and organelles. Bioinformatics analysis of the genome of the…”
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Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity by Pérez, Brian, Bouvier, León A, Cazzulo, Juan José, Agüero, Fernán, Salas-Sarduy, Emir, Alvarez, Vanina E

“…A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development…”
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SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms by Iribarren, Paula Ana, Di Marzio, Lucía Ayelén, Berazategui, María Agustina, De Gaudenzi, Javier Gerardo, Alvarez, Vanina Eder

“…SUMOylation is a post-translational modification conserved in eukaryotic organisms that involves the covalent attachment of the small ubiquitin-like protein…”
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Target-based Screening of the Chagas Box: Setting Up Enzymatic Assays to Discover Specific Inhibitors Across Bioactive Compounds by Salas-Sarduy, Emir, Niemirowicz, Gabriela T, José Cazzulo, Juan, Alvarez, Vanina E

“…Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin America with about 6 million…”
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DNA‐damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions by Bouvier, León A., Niemirowicz, Gabriela T., Salas‐Sarduy, Emir, Cazzulo, Juan José, Alvarez, Vanina E.

“…Metacaspases, distant relatives of metazoan caspases, have been shown to participate in programmed cell death in plants and in progression of the cell cycle…”
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SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes by Saura, Andreu, Iribarren, Paula A, Rojas‐Barros, Domingo, Bart, Jean M, López‐Farfán, Diana, Andrés‐León, Eduardo, Vidal‐Cobo, Isabel, Boehm, Cordula, Alvarez, Vanina E, Field, Mark C, Navarro, Miguel

“…SUMOylation is a post‐translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The…”
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Biosynthesis of SUMOylated Proteins in Bacteria Using the Trypanosoma brucei Enzymatic System by Iribarren, Paula Ana, Berazategui, María Agustina, Cazzulo, Juan José, Alvarez, Vanina Eder

“…Post-translational modification with the Small Ubiquitin-like Modifier (SUMO) is conserved in eukaryotic organisms and plays important regulatory roles in…”
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Hyperosmotic Stress Induces Aquaporin-dependent Cell Shrinkage, Polyphosphate Synthesis, Amino Acid Accumulation, and Global Gene Expression Changes in Trypanosoma cruzi by Li, Zhu-Hong, Alvarez, Vanina E., De Gaudenzi, Javier G., Sant'Anna, Celso, Frasch, Alberto C.C., Cazzulo, Juan J., Docampo, Roberto

“…The protist parasite Trypanosoma cruzi has evolved the ability to transit between completely different hosts and to replicate in adverse environments. In…”
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Update on relevant trypanosome peptidases: Validated targets and future challenges by Alvarez, Vanina E., Iribarren, Paula A., Niemirowicz, Gabriela T., Cazzulo, Juan José

“…Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents…”
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SUMOylation Pathway in Trypanosoma cruzi: Functional Characterization and Proteomic Analysis of Target Proteins by Bayona, Julio C., Nakayasu, Ernesto S., Laverrière, Marc, Aguilar, Clemente, Sobreira, Tiago J.P., Choi, Hyungwon, Nesvizhskii, Alexey I., Almeida, Igor C., Cazzulo, Juan J., Alvarez, Vanina E.

“…SUMOylation is a relevant protein post-translational modification in eukaryotes. The C terminus of proteolytically activated small ubiquitin-like modifier…”
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Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites by Iribarren, Paula Ana, Di Marzio, Lucía Ayelén, Berazategui, María Agustina, Saura, Andreu, Coria, Lorena, Cassataro, Juliana, Rojas, Federico, Navarro, Miguel, Alvarez, Vanina Eder

“…Trypanosoma brucei are protozoan parasites that cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host, a quorum sensing-like…”
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A 43-Nucleotide U-rich Element in 3′-Untranslated Region of Large Number of Trypanosoma cruzi Transcripts Is Important for mRNA Abundance in Intracellular Amastigotes by Li, Zhu-Hong, De Gaudenzi, Javier G., Alvarez, Vanina E., Mendiondo, Nicolás, Wang, Haiming, Kissinger, Jessica C., Frasch, Alberto C., Docampo, Roberto

“…Trypanosoma cruzi, the agent of Chagas disease, does not seem to control gene expression through regulation of transcription initiation and makes use of…”
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Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei by Obado, Samson O, Bot, Christopher, Echeverry, Maria C, Bayona, Julio C, Alvarez, Vanina E, Taylor, Martin C, Kelly, John M

“…Topoisomerase-II accumulates at centromeres during prometaphase, where it resolves the DNA catenations that represent the last link between sister chromatids…”
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Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes by Salas-Sarduy, Emir, Landaburu, Lionel Urán, Karpiak, Joel, Madauss, Kevin P., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina Eder

“…American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite…”
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Blocking autophagy to prevent parasite differentiation: A possible new strategy for fighting parasitic infections? by Alvarez, Vanina E., Kosec, Gregor, Sant'Anna, Celso, Turk, Vito, Cazzulo, Juan J., Turk, Boris

“…The genome of Trypanosoma cruzi was surveyed for autophagy-related genes. We have identified all the essential genes except for the Atg12 conjugation system…”
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Author Correction: Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes by Salas-Sarduy, Emir, Landaburu, Lionel Urán, Karpiak, Joel, Madauss, Kevin P., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina Eder

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper…”
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Simplified inducible system for Trypanosoma brucei by Niemirowicz, Gabriela T, Cazzulo, Juan J, Álvarez, Vanina E, Bouvier, León A

“…Nowadays, most reverse genetics approaches in Trypanosoma brucei, a protozoan parasite of medical and veterinary importance, rely on pre-established cell…”
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