Search Results - "Alvarez, Lautaro D"

Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor by Alvarez, Lautaro D., Pecci, Adali

“…[Display omitted] •The GABAAR-α1β2γ2 heteropentamer have four different neurosteroid binding sites.•All the sites are able to properly bind pregnanolone; two…”
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Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor by Presman, Diego M, Ogara, M Florencia, Stortz, Martín, Alvarez, Lautaro D, Pooley, John R, Schiltz, R Louis, Grøntved, Lars, Johnson, Thomas A, Mittelstadt, Paul R, Ashwell, Jonathan D, Ganesan, Sundar, Burton, Gerardo, Levi, Valeria, Hager, Gordon L, Pecci, Adali

“…Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses…”
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Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens by Alvarez, Lautaro D., Veleiro, Adriana S., Burton, Gerardo

“…ABSTRACT Salpichrolides are natural plant steroids that contain an unusual six‐membered aromatic ring D. We recently reported that some of these compounds, and…”
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Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors by Martínez, Mario D., Ghini, Alberto A., Dansey, M. Virginia, Veleiro, Adriana S., Pecci, Adali, Alvarez, Lautaro D., Burton, Gerardo

“…[Display omitted] •A series of cholanamides with modified A/B rings were synthesized.•6β,19-Epoxycholanamide 4 was an LXRα selective…”
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Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids by Presman, Diego M, Alvarez, Lautaro D, Levi, Valeria, Eduardo, Silvina, Digman, Michelle A, Martí, Marcelo A, Veleiro, Adriana S, Burton, Gerardo, Pecci, Adali

“…The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the…”
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Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle by Dansey, María V, Alvarez, Lautaro D, Samaja, Gisela, Escudero, Daiana S, Veleiro, Adriana S, Pecci, Adalí, Castro, Olga A, Burton, Gerardo

“…Dafachronic acids (DAs) are 3-keto cholestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the…”
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Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents by Sonego, Juan M., Rivero, Ezequiel M., Gargiulo, Lucía, Lüthy, Isabel, Alvarez, Lautaro D., Veleiro, Adriana S., Burton, Gerardo

“…The antiestrogenic activity of three natural salpichrolides A, G and B (1, 3 and 4) and of five synthetic analogs containing an aromatic D ring and a…”
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Structural Basis for Molecular Recognition of Cannabinoids by Inhibitory Cys-Loop Channels by Alvarez, Lautaro D., Carina Alves, N. R.

“…Cannabis sativa has a long history of medicinal use, dating back to ancient times. This plant produces cannabinoids, which are now known to interact with…”
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Mapping the neurosteroid binding sites on glycine receptors by Alvarez, Lautaro D., Pecci, Adali

“…[Display omitted] •Glycine receptors have five neurosteroid binding cavities.•Both overall flat and overall bent steroids are able to bind glycine…”
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In Search of GABA A Receptor's Neurosteroid Binding Sites by Alvarez, Lautaro D, Pecci, Adali, Estrin, Dario A

“…Neurosteroids (NS) are the main modulators of γ-aminobutyric acid type A receptors (GABA Rs), which are the ligand-gated channels target of the major…”
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Structure of the Glucocorticoid Receptor, a Flexible Protein That Can Adapt to Different Ligands by Veleiro, Adriana S., Alvarez, Lautaro D., Eduardo, Silvina L., Burton, Gerardo

“…Crystal structures of the glucocorticoid receptor (GR) ligand binding domain in complex with various agonists and antagonists give us an insight on how ligands…”
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In Search of GABAA Receptor's Neurosteroid Binding Sites by Alvarez, Lautaro D, Pecci, Adali, Estrin, Dario A

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Molecular determinants of tetrahydrocannabinol binding to the glycine receptor by Alvarez, Lautaro D., Alves, N. R. Carina

“…The recognition of Cannabis as a source of new compounds suitable for medical use has attracted strong interest from the scientific community in its research,…”
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Structural Insights into the Ligand Binding Domain of the Glucocorticoid Receptor: A Molecular Dynamics Study by Alves, N. R. Carina, Pecci, Adali, Alvarez, Lautaro D

“…The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation…”
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Hemisuccinate of 21-Hydroxy-6,19-Epoxyprogesterone: A Tissue-Specific Modulator of the Glucocorticoid Receptor by Álvarez, Lautaro D., Martí, Marcelo A., Veleiro, Adriana S., Misico, Rosana I., Estrin, Darío A., Pecci, Adalí, Burton, Gerardo

“…The introduction of a hemisuccinate group at the 21‐position of the passive antiglucocorticoid 21OH‐6,19OP leads to a compound (21HS‐6,19OP) with a notable…”
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Insights into estrogen receptor alpha modulation by cholestenoic acids by Dansey, María V., Palavecino Ruiz, Marcos D., Ogara, María F., Pecci, Adalí, Burton, Gerardo, Alvarez, Lautaro D.

“…[Display omitted] •The cholesterol metabolite cholestenoic acid is an ERα agonist.•Cholestenoic acid analogues with an unsaturated the side chain are also ERα…”
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Exploring the molecular basis of neurosteroid binding to the β3 homopentameric GABAA receptor by Alvarez, Lautaro D., Estrin, Darío A.

“…•A neurosteroid binding site was identified in the β3 Homopentameric GABAA receptor.•The site is able to bind both overall torsioned and flat steroids.•Its…”
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Expanding the Repertoire of ceDAF‐12 Ligands for Modulation of the Steroid Endocrine System in C. Elegans by Galilea, Agustín, Santillán, Vanessa J., Acebedo, Sofía L., Virginia Dansey, María, Álvarez, Lautaro D., Mazaira, Gisela I., Galigniana, Mario D., Castro, Olga A., Gola, Gabriel F., Ramírez, Javier A.

“…Steroid hormones are essential for the biological processes of eukaryotic organisms. The steroid endocrine system of C. elegans, which includes dafachronic…”
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Cholestenoic acid analogues as inverse agonists of the liver X receptors by Alvarez, Lautaro D., Dansey, María V., Ogara, María F., Peña, Carina I., Houtman, René, Veleiro, Adriana S., Pecci, Adali, Burton, Gerardo

“…[Display omitted] •Five new analogues of cholestenoic acid were synthesized•Δ24 analogues with E configuration were inverse agonists of LXRs•Δ24 analogues with…”
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Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity by Rodriguez, Cristian R., Alvarez, Lautaro D., Dansey, M.Virginia, Paolo, Luciano S., Veleiro, Adriana S., Pecci, Adali, Burton, Gerardo

“…[Display omitted] •Difluoro-oxysterols were prepared by Reformatsky reaction with ultrasound irradiation.•25,25-Difluoro-27-norcholestenoic acid was an inverse…”
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