Search Results - "Alvarado, Alvaro"

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes by Li, Jiwen, Pan, Lin, Pembroke, William G., Rexach, Jessica E., Godoy, Marlesa I., Condro, Michael C., Alvarado, Alvaro G., Harteni, Mineli, Chen, Yen-Wei, Stiles, Linsey, Chen, Angela Y., Wanner, Ina B., Yang, Xia, Goldman, Steven A., Geschwind, Daniel H., Kornblum, Harley I., Zhang, Ye

“…Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on…”
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Interfer(on)ing with Zika virus by Alvarado, Alvaro G., Kornblum, Harley I.

“…In this issue of Neuron, Bulstrode et al.1 demonstrate that glioblastoma slice cultures, unlike neural progenitors, are refractory to Zika virus infection. The…”
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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression by Alvarado, Alvaro G., Thiagarajan, Praveena S., Mulkearns-Hubert, Erin E., Silver, Daniel J., Hale, James S., Alban, Tyler J., Turaga, Soumya M., Jarrar, Awad, Reizes, Ofer, Longworth, Michelle S., Vogelbaum, Michael A., Lathia, Justin D.

“…Tumors contain hostile inflammatory signals generated by aberrant proliferation, necrosis, and hypoxia. These signals are sensed and acted upon acutely by the…”
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Cancer Stem Cell‐Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion by Otvos, Balint, Silver, Daniel J., Mulkearns‐Hubert, Erin E., Alvarado, Alvaro G., Turaga, Soumya M., Sorensen, Mia D., Rayman, Patricia, Flavahan, William A, Hale, James S., Stoltz, Kevin, Sinyuk, Maksim, Wu, Qiulian, Jarrar, Awad, Kim, Sung‐Hak, Fox, Paul L., Nakano, Ichiro, Rich, Jeremy N., Ransohoff, Richard M., Finke, James, Kristensen, Bjarne W., Vogelbaum, Michael A., Lathia, Justin D.

“…Shifting the balance away from tumor‐mediated immune suppression toward tumor immune rejection is the conceptual foundation for a variety of immunotherapy…”
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Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance by Adorno-Cruz, Valery, Kibria, Golam, Liu, Xia, Doherty, Mary, Junk, Damian J, Guan, Dongyin, Hubert, Chris, Venere, Monica, Mulkearns-Hubert, Erin, Sinyuk, Maksim, Alvarado, Alvaro, Caplan, Arnold I, Rich, Jeremy, Gerson, Stanton L, Lathia, Justin, Liu, Huiping

“…With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell…”
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Cancer Stem Cell‐Specific Scavenger Receptor CD36 Drives Glioblastoma Progression by Hale, James S., Otvos, Balint, Sinyuk, Maksim, Alvarado, Alvaro G., Hitomi, Masahiro, Stoltz, Kevin, Wu, Qiulian, Flavahan, William, Levison, Bruce, Johansen, Mette L., Schmitt, David, Neltner, Janna M., Huang, Ping, Ren, Bin, Sloan, Andrew E., Silverstein, Roy L., Gladson, Candece L., DiDonato, Joseph A., Brown, J. Mark, McIntyre, Thomas, Hazen, Stanley L., Horbinski, Craig, Rich, Jeremy N., Lathia, Justin D.

“…Glioblastoma (GBM) contains a self‐renewing, tumorigenic cancer stem cell (CSC) population which contributes to tumor propagation and therapeutic resistance…”
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Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase by Thiagarajan, Praveena S., Sinyuk, Maksim, Turaga, Soumya M., Mulkearns-Hubert, Erin E., Hale, James S., Rao, Vinay, Demelash, Abeba, Saygin, Caner, China, Arnab, Alban, Tyler J., Hitomi, Masahiro, Torre-Healy, Luke A., Alvarado, Alvaro G., Jarrar, Awad, Wiechert, Andrew, Adorno-Cruz, Valery, Fox, Paul L., Calhoun, Benjamin C., Guan, Jun-Lin, Liu, Huiping, Reizes, Ofer, Lathia, Justin D.

“…Tumors adapt their phenotypes during growth and in response to therapies through dynamic changes in cellular processes. Connexin proteins enable such dynamic…”
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Differential Connexin Function Enhances Self-Renewal in Glioblastoma by Hitomi, Masahiro, Deleyrolle, Loic P., Mulkearns-Hubert, Erin E., Jarrar, Awad, Li, Meizhang, Sinyuk, Maksim, Otvos, Balint, Brunet, Sylvain, Flavahan, William A., Hubert, Christopher G., Goan, Winston, Hale, James S., Alvarado, Alvaro G., Zhang, Ao, Rohaus, Mark, Oli, Muna, Vedam-Mai, Vinata, Fortin, Jeff M., Futch, Hunter S., Griffith, Benjamin, Wu, Qiulian, Xia, Chun-hong, Gong, Xiaohua, Ahluwalia, Manmeet S., Rich, Jeremy N., Reynolds, Brent A., Lathia, Justin D.

“…The coordination of complex tumor processes requires cells to rapidly modify their phenotype and is achieved by direct cell-cell communication through gap…”
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Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth by Muthukrishnan, Sree Deepthi, Qi, Haocheng, Wang, David, Elahi, Lubayna, Pham, Amy, Alvarado, Alvaro G, Li, Tie, Gao, Fuying, Kawaguchi, Riki, Lai, Albert, Kornblum, Harley I

“…A key feature distinguishing high-grade glioma (HG) from low-grade glioma (LG) is the extensive neovascularization and endothelial hyperproliferation. Prior…”
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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma by Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G, Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I, Jin, Lingjing, Li, Hua, Ye, Keqiang

“…Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase…”
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Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells by Alvarado, Alvaro G, Lathia, Justin D

“…Innate immunity has evolved as the front-line cellular defense mechanism to acutely sense and decisively respond to microenvironmental alterations. The…”
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Cancer Stem Cell-Specific Scavenger Receptor 36 Drives Glioblastoma Progression by Hale, James S, Otvos, Balint, Sinyuk, Maksim, Alvarado, Alvaro G, Hitomi, Masahiro, Stoltz, Kevin, Wu, Qiulian, Flavahan, William, Levison, Bruce, Johansen, Mette L, Schmitt, David, Neltner, Janna M, Huang, Ping, Ren, Bin, Sloan, Andrew E, Silverstein, Roy L, Gladson, Candece L, DiDonato, Joseph A, Brown, J Mark, McIntyre, Thomas, Hazen, Stanley L, Horbinski, Craig, Rich, Jeremy N, Lathia, Justin D

“…Glioblastoma (GBM) contains a self-renewing, tumorigenic cancer stem cell (CSC) population which contributes to tumor propagation and therapeutic resistance…”
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Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression by Muthukrishnan, Sree Deepthi, Alvarado, Alvaro G., Kornblum, Harley I.

“…Little is currently known about how cancer stem-like cells (CSCs) interact with their more restricted progeny. In this issue of Cell Stem Cell, Wang et al…”
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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells by Muthukrishnan, Sree Deepthi, Kawaguchi, Riki, Nair, Pooja, Prasad, Rachna, Qin, Yue, Johnson, Maverick, Wang, Qing, VanderVeer-Harris, Nathan, Pham, Amy, Alvarado, Alvaro G., Condro, Michael C., Gao, Fuying, Gau, Raymond, Castro, Maria G., Lowenstein, Pedro R., Deb, Arjun, Hinman, Jason D., Pajonk, Frank, Burns, Terry C., Goldman, Steven A., Geschwind, Daniel H., Kornblum, Harley I.

“…Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms…”
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A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes by Giachino, Claudio, Boulay, Jean-Louis, Ivanek, Robert, Alvarado, Alvaro, Tostado, Cristobal, Lugert, Sebastian, Tchorz, Jan, Coban, Mustafa, Mariani, Luigi, Bettler, Bernhard, Lathia, Justin, Frank, Stephan, Pfister, Stefan, Kool, Marcel, Taylor, Verdon

“…In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an…”
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Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple‐Negative Breast Cancer by Thiagarajan, Praveena S., Hitomi, Masahiro, Hale, James S., Alvarado, Alvaro G., Otvos, Balint, Sinyuk, Maksim, Stoltz, Kevin, Wiechert, Andrew, Mulkearns‐Hubert, Erin, Jarrar, Awad M., Zheng, Qiao, Thomas, Dustin, Egelhoff, Thomas T., Rich, Jeremy N., Liu, Huiping, Lathia, Justin D., Reizes, Ofer

“…Advanced cancers display cellular heterogeneity driven by self‐renewing, tumorigenic cancer stem cells (CSCs). The use of cell lines to model CSCs is…”
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A 4-miRNA signature to predict survival in glioblastomas by Hermansen, Simon K, Sørensen, Mia D, Hansen, Anker, Knudsen, Steen, Alvarado, Alvaro G, Lathia, Justin D, Kristensen, Bjarne W

“…Glioblastomas are among the most lethal cancers; however, recent advances in survival have increased the need for better prognostic markers. microRNAs (miRNAs)…”
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High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma by Alban, Tyler J, Bayik, Defne, Alvarado, Alvaro G, Kornblum, Harley I, Lathia, Justin D

“…We will first describe analysis of MDSC subsets from patient tumors with multicolor flow cytometry. The key components of this methodology are to obtain viable…”
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Infrared Thermography Smart Sensor for the Condition Monitoring of Gearbox and Bearings Faults in Induction Motors by Alvarado-Hernandez, Alvaro Ivan, Zamudio-Ramirez, Israel, Jaen-Cuellar, Arturo Yosimar, Osornio-Rios, Roque Alfredo, Donderis-Quiles, Vicente, Antonino-Daviu, Jose Alfonso

“…The monitoring of machine conditions is very important from the viewpoints of productivity, economic benefits, and maintenance. Several techniques have been…”
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Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis by Alban, Tyler J, Alvarado, Alvaro G, Sorensen, Mia D, Bayik, Defne, Volovetz, Josephine, Serbinowski, Emily, Mulkearns-Hubert, Erin E, Sinyuk, Maksim, Hale, James S, Onzi, Giovana R, McGraw, Mary, Huang, Pengjing, Grabowski, Matthew M, Wathen, Connor A, Ahluwalia, Manmeet S, Radivoyevitch, Tomas, Kornblum, Harley I, Kristensen, Bjarne W, Vogelbaum, Michael A, Lathia, Justin D

“…Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune cells in the microenvironment, there is limited antitumor immune…”
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