Search Results - "Aluise, Christopher D"

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: Toward therapeutic modulation of mild cognitive impairment by Huang, Quanzhen, Aluise, Christopher D., Joshi, Gururaj, Sultana, Rukhsana, St. Clair, Daret K., Markesbery, William R., Butterfield, D. Allan

“…Alzheimer's disease (AD) is the most prevalent form of dementia among the elderly. Although the underlying cause has yet to be established, numerous data have…”
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Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction by Aluise, Christopher D, Sultana, Rukhsana, Tangpong, Jitbangjong, Vore, Mary, St Clair, Daret, Moscow, Jeffrey A, Butterfield, D Allan

“…Doxorubicin (ADRIAMYCIN, RUBEX) is a chemotherapeutic agent that is commonly administered to breast cancer patients in standard chemotherapy regimens. As true…”
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Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics by Aluise, Christopher D, Robinson, Renã A. Sowell, Beckett, Tina L, Murphy, M. Paul, Cai, Jian, Pierce, William M, Markesbery, William R, Butterfield, D. Allan

“…Abstract Alzheimer disease (AD) is a neurodegenerative disorder characterized clinically by progressive memory loss and subsequent dementia and…”
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In vivo amelioration of adriamycin induced oxidative stress in plasma by gamma-glutamylcysteine ethyl ester (GCEE) by Aluise, Christopher D, St. Clair, Daret, Vore, Mary, Butterfield, D. Allan

“…Abstract Adriamycin (ADR) is a common chemotherapeutic known to generate significant amounts of reactive oxygen species (ROS). Although ROS generation is one…”
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2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain by Aluise, Christopher D., Miriyala, Sumitra, Noel, Teresa, Sultana, Rukhsana, Jungsuwadee, Paiboon, Taylor, Tamara J., Cai, Jian, Pierce, William M., Vore, Mary, Moscow, Jeffrey A., St Clair, Daret K., Butterfield, D. Allan

“…Doxorubicin (DOX), an anthracycline used to treat a variety of cancers, is known to generate intracellular reactive oxygen species. Moreover, many patients who…”
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Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain by Owen, Joshua B., Sultana, Rukhsana, Aluise, Christopher D., Erickson, Michelle A., Price, Tulin O., Bu, Guojun, Banks, William A., Butterfield, D. Allan

“…Alzheimer disease (AD) is a neurodegenerative disorder characterized histopathologically by the presence of senile plaques (SPs), neurofibrillary tangles, and…”
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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor by McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J

“…The beta-site APP cleaving enzyme 1, known as BACE1, has been a widely pursued Alzheimer’s disease drug target owing to its critical role in the production of…”
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Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI by Aluise, Christopher D, Robinson, Renã A S, Cai, Jian, Pierce, William M, Markesbery, William R, Butterfield, D Allan

“…Alzheimer's disease (AD) is a central nervous system disorder pathologically characterized by senile plaques, neurofibrillary tangles, and synapse loss. A…”
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Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4‑Oxo-2-nonenal by Aluise, Christopher D, Camarillo, Jeannie M, Shimozu, Yuki, Galligan, James J, Rose, Kristie L, Tallman, Keri A, Marnett, Lawrence J

“…Products of oxidative damage to lipids include 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE), both of which are cytotoxic electrophiles. ONE reacts more…”
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Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease by Aluise, Christopher D., Sowell, Renã A., Butterfield, D. Allan

“…Alzheimer's disease (AD) affects millions of persons worldwide. Earlier detection and/or diagnosis of AD would permit earlier intervention, which conceivably…”
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Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles by Aluise, Christopher D, Rose, Kristie, Boiani, Mariana, Reyzer, Michelle L, Manna, Joseph D, Tallman, Keri, Porter, Ned A, Marnett, Lawrence J

“…Oxidation of membrane phospholipids is associated with inflammation, neurodegenerative disease, and cancer. Oxyradical damage to phospholipids results in the…”
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Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species by Willis, Brian A., Lowe, Stephen L., Monk, Scott A., Cocke, Patrick J., Aluise, Christopher D., Boggs, Leonard N., Borders, Anthony R., Brier, Richard A., Dean, Robert A., Green, Steven J., James, Douglas E., Jhee, Stanford S., Lin, Qun, Lo, Albert C., May, Patrick C., Watson, Brian M., Winneroski, Leonard L., Yang, Zhixiang, Zimmer, Jennifer A., McKinzie, David L., Mergott, Dustin J.

“…Background: The development of beta-site amyloid-beta precursor protein cleaving enzyme (BACE) 1 inhibitors for the treatment of Alzheimer’s disease requires…”
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P1-353: Toward biomarker developments in Alzheimer's disease: Proteomic analysis of blood plasma from normally cognitive persons compared with plasma from the same persons following diagnosis of Alzheimer's disease by Aluise, Christopher D

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Pin1 is a Target for Oxidative Modification by the Lipid Electrophiles 4-Hydroxynonenal and 4- Oxononenal by Aluise, Christopher D, Marnett, Lawrence J

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PSS318 - Pin1 is a Target for Oxidative Modification by the Lipid Electrophiles 4-Hydroxynonenal and 4- Oxononenal by Aluise, Christopher D, Marnett, Lawrence J

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Abstract 2062: Peptidylprolyl cis/trans isomerase A1 (Pin1) is modified by lipid electrophiles generated during oxidative stress by Aluise, Christopher D., Marnett, Lawrence J.

“…Oxidation of membrane phospholipids is associated with inflammation and cancer. Phospholipid peroxidation results in the production of reactive electrophiles…”
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Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain by Joshi, G, Aluise, C.D, Cole, M.P, Sultana, R, Pierce, W.M, Vore, M, St Clair, D.K, Butterfield, D.A

“…Abstract Adriamycin (ADR) is a chemotherapeutic for the treatment of solid tumors. This quinone-containing anthracycline is well known to produce large amounts…”
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4-oxo-2-nonenal Adduction of Chromatin: a Novel Post-Translational Modification to Histones by Galligan, James J, Rose, Kristie L, Kudalkar, Shalley N, Beavers, William N, Aluise, Christopher D, Marnett, Lawrence J

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350 - 4-oxo-2-nonenal Adduction of Chromatin: a Novel Post-Translational Modification to Histones by Galligan, James J, Rose, Kristie L, Kudalkar, Shalley N, Beavers, William N, Aluise, Christopher D, Marnett, Lawrence J

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Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Ab accumulation in AD brain by Owen, Joshua B, Sultana, Rukhsana, Aluise, Christopher D, Erickson, Michelle A, Price, Tulin O, Bu, Guojun, Banks, William A, Butterfield, DAllan

“…Alzheimer disease (AD) is a neurodegenerative disorder characterized histopathologically by the presence of senile plaques (SPs), neurofibrillary tangles, and…”
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