Search Results - "Aluicio‐Sarduy, Eduardo"
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Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics
Published in Advanced functional materials (15-08-2023)“…The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL)…”
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Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications
Published in Chemistry : a European journal (27-01-2020)“…We report the first targeted nuclear medicine application of the lanthanum radionuclides 132/135La. These isotopes represent a matched pair for diagnosis via…”
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Construction of the Bioconjugate Py‐Macrodipa‐PSMA and Its In Vivo Investigations with Large 132/135La3+ and Small 47Sc3+ Radiometal Ions
Published in European journal of inorganic chemistry (12-12-2023)“…To harness radiometals in clinical settings, a chelator forming a stable complex with the metal of interest and targets the desired pathological site is…”
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4
“Off‐Label Use” of the Siderophore Enterobactin Enables Targeted Imaging of Cancer with Radioactive Ti(IV)
Published in Angewandte Chemie (International ed.) (24-04-2024)“…The development of inert, biocompatible chelation methods is required to harness the emerging positron emitting radionuclide 45Ti for radiopharmaceutical…”
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PET radiometals for antibody labeling
Published in Journal of labelled compounds & radiopharmaceuticals (01-07-2018)“…Recent advances in molecular characterization of tumors have made possible the emergence of new types of cancer therapies where traditional cytotoxic drugs and…”
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6
Electric field induced structural colour tuning of a silver/titanium dioxide nanoparticle one-dimensional photonic crystal
Published in Beilstein journal of nanotechnology (2016)“…An electric field is employed for the active tuning of the structural colour in photonic crystals, which acts as an effective external stimulus with an impact…”
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All Solution-Processed, Hybrid Organic–Inorganic Photocathode for Hydrogen Evolution
Published in ACS omega (31-07-2017)“…Nowadays, the efficient, stable, and scalable conversion of solar energy into chemical fuels represents a great scientific, economic, and ethical challenge…”
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Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
Published in Science translational medicine (14-07-2021)“…Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help prime and propagate antitumor immunity. We hypothesized that delivering…”
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Py-Macrodipa: A Janus Chelator Capable of Binding Medicinally Relevant Rare-Earth Radiometals of Disparate Sizes
Published in Journal of the American Chemical Society (14-07-2021)“…Nuclear medicine leverages different types of radiometals for disease diagnosis and treatment, but these applications usually require them to be stably…”
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10
Controlling the Redox Chemistry of Cobalt Radiopharmaceuticals
Published in Angewandte Chemie International Edition (23-09-2024)“…The elementally matched 55Co (t1/2 = 17.53 h, Iβ+ = 77%)/58mCo (t1/2 = 9.10 h, IC= 100%) radioisotope pair is of interest for development of paired…”
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11
Construction of the Bioconjugate Py-Macrodipa-PSMA and Its In Vivo Investigations with Large 132/135 La 3+ and Small 47 Sc 3+ Radiometal Ions
Published in European journal of inorganic chemistry (12-12-2023)“…To harness radiometals in clinical settings, a chelator forming a stable complex with the metal of interest and targets the desired pathological site is…”
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12
[nat/44Sc(pypa)]−: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate
Published in Inorganic chemistry (03-02-2020)“…44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized…”
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Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting
Published in PloS one (12-08-2021)“…Murine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary tumor in situ vaccination combined with targeted…”
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A High Separation Factor for 165Er from Ho for Targeted Radionuclide Therapy
Published in Molecules (Basel, Switzerland) (11-12-2021)“…Background: Radionuclides emitting Auger electrons (AEs) with low (0.02–50 keV) energy, short (0.0007–40 µm) range, and high (1–10 keV/µm) linear energy…”
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15
Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
Published in Theranostics (01-01-2021)“…Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1…”
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Frontispiece: Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications
Published in Chemistry : a European journal (27-01-2020)“…The image describes the radiochemical complexation of the novel radionuclides 132La and 135La for coupling with prostate cancer targeting moieties, with…”
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PET Imaging of the Neurotensin Targeting Peptide NOTA-NT-20.3 Using Cobalt-55, Copper-64 and Gallium-68
Published in Pharmaceutics (06-12-2022)“…Introduction: Neurotensin receptor 1 (NTSR1) is an emerging target for imaging and therapy of many types of cancer. Nuclear imaging of NTSR1 allows for…”
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86/90Y‑Labeled Monoclonal Antibody Targeting Tissue Factor for Pancreatic Cancer Theranostics
Published in Molecular pharmaceutics (04-05-2020)“…Pancreatic cancer is highly aggressive, with a median survival time of less than 6 months and a 5-year overall survival rate of around 7%. The poor prognosis…”
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Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47
Published in Current radiopharmaceuticals (01-01-2021)“…Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant…”
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Sustainable production of radionuclidically pure antimony-119
Published in EJNMMI radiopharmacy and chemistry (22-10-2024)“…Background Radiopharmaceutical therapy (RPT) uses radionuclides that decay via one of three therapeutically relevant decay modes (alpha, beta, and internal…”
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