Search Results - "Altura, R A"

Safety and efficacy of quavonlimab, a novel anti-CTLA-4 antibody (MK-1308), in combination with pembrolizumab in first-line advanced non-small-cell lung cancer by Perets, R., Bar, J., Rasco, D.W., Ahn, M.-J., Yoh, K., Kim, D.-W., Nagrial, A., Satouchi, M., Lee, D.H., Spigel, D.R., Kotasek, D., Gutierrez, M., Niu, J., Siddiqi, S., Li, X., Cyrus, J., Chackerian, A., Chain, A., Altura, R.A., Cho, B.C.

“…Quavonlimab (MK-1308), a novel anti-CTLA-4 antibody, in combination with pembrolizumab was investigated in a phase I study. Dose-escalation (DE) phase:…”
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Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases by FANGUSARO, J, KLOPFENSTEIN, K, GRONER, J, HAMMOND, S, ALTURA, R. A

“…Inflammatory myofibroblastic tumors are benign neoplasms histologically composed of lymphocytes, histiocytes, macrophages, foam cells, and plasma cells among a…”
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Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade by ALTURA, R. A, OLSHEFSKI, R. S, JIANG, Y, BOUE, D. R

“…Survivin is a gene that is widely expressed throughout the development of the normal mammalian embryo. Subcellular localisation of Survivin to both the nucleus…”
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Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo by Caldas, H, Holloway, M P, Hall, B M, Qualman, S J, Altura, R A

“…Background: Survivin is proposed to play a central role in the progression and resistance to therapy of diverse tumour types. High levels of this molecule in…”
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Survivin, Survivin-2B, and Survivin-deltaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome by FANGUSARO, J. R, JIANG, Y, HOLLOWAY, M. P, CALDAS, H, SINGH, V, BOUE, D. R, HAYES, J, ALTURA, R. A

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Phase I study of the CTLA-4 inhibitor MK-1308 in combination with pembrolizumab in patients with advanced solid tumors by Cho, B C, Perets, R, Bar, J, Ahn, M-J, Kim, D-W, Yoh, K, Nagrial, A, Spigel, D R, Lee, D H, Gutierrez, M, Kotasek, D, Siddiqi, S, Chain, A, Butts, B D, Zhang, Y, Li, X, Cyrus, J, Tse, A, Altura, R A, Rasco, D

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Survivin splice variants regulate the balance between proliferation and cell death by CALDAS, Hugo, YUYING JIANG, HOLLOWAY, Michael P, FANGUSARO, Jason, MAHOTKA, Csaba, CONWAY, Edward M, ALTURA, Rachel A

“…Survivin is an inhibitor of apoptosis protein that also plays critical roles in regulating the cell cycle and mitosis. Its prominent expression in essentially…”
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Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization by ALTURA, R. A, VALENTINE, M, LI, H, BOYETT, J. M, SHEARER, P, GRUNDY, P, SHAPIRO, D. N, LOOK, A. T

“…Wilms' tumor, an embryonic renal neoplasm diagnosed primarily in young children, can occur in either a noninheritable (sporadic) or a familial form, with the…”
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Long‐term survival of infants with idiopathic myelofibrosis by Altura, Rachel A., Head, David R., Wang, Winfred C.

“…Idiopathic myelofibrosis can develop in children as well as adults. However, the disease appears to be much more aggressive in adults, being characterized by…”
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414PDPhase I study of the CTLA-4 inhibitor MK-1308 in combination with pembrolizumab in patients with advanced solid tumors by Cho, B C, Perets, R, Bar, J, Ahn, M-J, Kim, D-W, Yoh, K, Nagrial, A, Spigel, D R, Lee, D H, Gutierrez, M, Kotasek, D, Siddiqi, S, Chain, A, Butts, B D, Zhang, Y, Li, X, Cyrus, J, Tse, A, Altura, R A, Rasco, D

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Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization by Altura, Rachel A., Maris, John M., Li, Hao, Boyett, James M., Brodeur, Garrett M., Look, A. Thomas

“…Childhood neuroblastoma, an embryonal neoplasm of sympathetic nervous system progenitors, occurs in a familial form with an autosomal dominant mode of…”
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The Chimeric E2A-HLF Transcription Factor Abrogates p53-Induced Apoptosis in Myeloid Leukemia Cells by Altura, Rachel A., Inukai, Takeshi, Ashmun, Richard A., Zambetti, Gerard P., Roussel, Martine F., Look, A. Thomas

“…Leukemic lymphoblasts expressing the E2A-HLF oncoprotein possess wild-type p53 genes, but do not undergo apoptosis in response to DNA damage. Experimentally,…”
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Aberrant Regulation of Survivin by the RB/E2F Family of Proteins by Jiang, Yuying, Saavedra, Harold I., Holloway, Michael P., Leone, Gustavo, Altura, Rachel A.

“…Survivin is a putative oncogene that is aberrantly expressed in cancer cells. It has been hypothesized to play a central role in cancer progression and…”
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Essential Role for Survivin in Early Brain Development by Jiang, Yuying, de Bruin, Alain, Caldas, Hugo, Fangusaro, Jason, Hayes, John, Conway, Edward M, Robinson, Michael L, Altura, Rachel A

“…Apoptosis is an essential process during normal neuronal development. Approximately one-half of the neurons produced during neurogenesis die before completion…”
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Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome by Fangusaro, J R, Jiang, Y, Holloway, M P, Caldas, H, Singh, V, Boué, D R, Hayes, J, Altura, R A

“…Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin,…”
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Survivin and Granzyme B–induced apoptosis, a novel anticancer therapy by Caldas, Hugo, Jaynes, Florinda O, Boyer, Michael W, Hammond, Sue, Altura, Rachel A

“…Survivin is an antiapoptotic protein highly expressed in malignant cells that confers resistance to cytotoxic therapy. Granzyme B is a potent cytotoxic protein…”
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Serum ionized magnesium levels and ionized calcium‐to‐magnesium ratios in adult patients with sickle cell anemia by Zehtabchi, Shahriar, Sinert, Richard, Rinnert, Stephan, Chang, Betty, Heinis, Christian, Altura, Rachel A., Altura, Bella T., Altura, Burton M.

“…Low levels of total magnesium in sickle cell erythrocytes have been linked to increased sickling due to cell dehydration. We tested the null hypothesis that…”
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The Chimeric E2A-HLF Transcription Factor Abrogates p53-Induced Apoptosis in Myeloid Leukemia Cells by Altura, Rachel A., Inukai, Takeshi, Ashmun, Richard A., Zambetti, Gerard P., Roussel, Martine F., Look, A. Thomas

“…Leukemic lymphoblasts expressing the E2A-HLF oncoprotein possess wild-type p53 genes, but do not undergo apoptosis in response to DNA damage. Experimentally,…”
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Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell anemia by Altura, Rachel A., Wang, Winfred C., Wynn, Lynn, Altura, Burton M., Altura, Bella T.

“…Objective: To obtain quantitative serum levels of total and ionized magnesium (Mg2+) in children with homozygous sickle cell anemia (SCA) undergoing therapy…”
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The perils of carbonic acid and equilibrium constants by Jencks, William P, Altura, Rachel A

“…It is important to remember that the small amounts of carbon dioxide that are usually present in water can have large effects on acid-base equilibria of dilute…”
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