Search Results - "Altuntas, Cengiz Z"

Crimean-Congo hemorrhagic fever virus entry into host cells occurs through the multivesicular body and requires ESCRT regulators by Shtanko, Olena, Nikitina, Raisa A, Altuntas, Cengiz Z, Chepurnov, Alexander A, Davey, Robert A

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus causing outbreaks of severe disease in humans, with a fatality rate approaching 30%…”
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Uroplakin peptide-specific autoimmunity initiates interstitial cystitis/painful bladder syndrome in mice by Izgi, Kenan, Altuntas, Cengiz Z, Bicer, Fuat, Ozer, Ahmet, Sakalar, Cagri, Li, Xiaoxia, Tuohy, Vincent K, Daneshgari, Firouz

“…The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic. Autoimmunity and impaired urothelium might lead the underlying…”
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Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model by Bicer, Fuat, Altuntas, Cengiz Z, Izgi, Kenan, Ozer, Ahmet, Kavran, Michael, Tuohy, Vincent K, Daneshgari, Firouz

“…The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS) remains unclear; autoimmunity is a possible etiology. We have…”
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The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation by Gulen, Muhammet F., Kang, Zizhen, Bulek, Katarzyna, Youzhong, Wan, Kim, Tae Whan, Chen, Yi, Altuntas, Cengiz Z., Sass Bak-Jensen, Kristian, McGeachy, Mandy J., Do, Jeong-Su, Xiao, Hui, Delgoffe, Greg M., Min, Booki, Powell, Jonathan D., Tuohy, Vincent K., Cua, Daniel J., Li, Xiaoxia

“…Interleukin-1 (IL-1)-mediated signaling in T cells is essential for T helper 17 (Th17) cell differentiation. We showed here that SIGIRR, a negative regulator…”
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Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis by Altuntas, Cengiz Z, Daneshgari, Firouz, Sakalar, Cagri, Goksoy, Esen, Gulen, M. Fatih, Kavran, Michael, Qin, Jun, Li, Xiaoxia, Tuohy, Vincent K

“…Abstract Background The pathophysiology of interstitial cystitis (IC) is unknown. Deficits in urothelial cell layers and autoimmune mechanisms may play a role…”
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β1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis by JANE-WIT, Daniel, ALTUNTAS, Cengiz Z, PEREZ, Dianne M, TUOHY, Vincent K, JOHNSON, Justin M, YONG, Sandro, WICKLEY, Peter J, CLARK, Pamela, QING WANG, POPOVIC, Zoran B, PENN, Marc S, DAMRON, Derek S

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IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease by Staschke, Kirk A, Dong, Sucai, Saha, Joy, Zhao, Jingyong, Brooks, Nathan A, Hepburn, Deena L, Xia, Jinqi, Gulen, Muhammet F, Kang, Zizhen, Altuntas, Cengiz Z, Tuohy, Vincent K, Gilmour, Raymond, Li, Xiaoxia, Na, Songqing

“…Both IL-23- and IL-1-mediated signaling pathways play important roles in Th17 cell differentiation, cytokine production, and autoimmune diseases. The…”
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Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis by Lin, Yi‐Hao, Liu, Guiming, Kavran, Michael, Altuntas, Cengiz Z., Gasbarro, Gregory, Tuohy, Vincent K., Daneshgari, Firouz

“…OBJECTIVE To examine bladder function in a newly developed experimental autoimmune cystitis (EAC) model in female SWXJ strain mice, as a potential animal model…”
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Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II by Tuohy, Vincent K., Connolly, Denise C., Aguilar, Robert, Jaini, Ritika, Altuntas, Cengiz Z., Johnson, Justin M., Mazumder, Suparna, Sakalar, Cagri, Prasad, Sathyamangla V. Naga

“…Anti-Müllerian hormone receptor, type II (AMHR2), is a differentiation protein expressed in 90% of primary epithelial ovarian carcinomas (EOCs), the most…”
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Synergistic Interaction of Paclitaxel and Curcumin with Cyclodextrin Polymer Complexation in Human Cancer Cells by Boztas, Ali O, Karakuzu, Ozgur, Galante, Gabriela, Ugur, Zafer, Kocabas, Fatih, Altuntas, Cengiz Z, Yazaydin, A. Ozgur

“…The use of cytotoxic chemotherapic agents is the most common method for the treatment of metastatic cancers. Poor water solubility and low efficiency of…”
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An autoimmune-mediated strategy for prophylactic breast cancer vaccination by Jaini, Ritika, Kesaraju, Pavani, Johnson, Justin M, Altuntas, Cengiz Z, Jane-wit, Daniel, Tuohy, Vincent K

“…Although vaccination is most effective when used to prevent disease, cancer vaccine development has focused predominantly on providing therapy against…”
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Disruption of estrous cycle homeostasis in mice with experimental autoimmune encephalomyelitis by Jaini, Ritika, Altuntas, Cengiz Z, Loya, Matthew G, Tuohy, Vincent K

“…Abstract Multiple sclerosis (MS) is widely viewed as a prototypic human autoimmune disease involving proinflammatory T cells that induce lesions in the central…”
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Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice by Ozer, Ahmet, Altuntas, Cengiz Z., Izgi, Kenan, Bicer, Fuat, Hultgren, Scott J., Liu, Guiming, Daneshgari, Firouz

“…Diabetic individuals have increased susceptibility to urinary tract infection (UTI), a common, painful condition. During diabetes mellitus, non-enzymatic…”
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Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice by Ozer, Ahmet, Altuntas, Cengiz Z., Bicer, Fuat, Izgi, Kenan, Hultgren, Scott J., Liu, Guiming, Daneshgari, Firouz

“…Diabetic patients have increased susceptibility to infections, and urinary tract infections (UTI) are the most common type in women with diabetes mellitus…”
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Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder by Altuntas, Cengiz Z, Daneshgari, Firouz, Izgi, Kenan, Bicer, Fuat, Ozer, Ahmet, Sakalar, Cagri, Grimberg, Kerry O, Sayin, Ismail, Tuohy, Vincent K

“…We previously reported that mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), develop profound urinary bladder…”
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IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production by Liu, Jinbo, Lin, Feng, Strainic, Michael G, An, Fengqi, Miller, Robert H, Altuntas, Cengiz Z, Heeger, Peter S, Tuohy, Vincent K, Medof, M Edward

“…IFN-gamma- and IL-17-producing T cells autoreactive across myelin components are central to the pathogenesis of multiple sclerosis. Using direct in vivo,…”
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A novel murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induced by immunization with a spermine binding protein (p25) peptide by Altuntas, Cengiz Z, Daneshgari, Firouz, Veizi, Elias, Izgi, Kenan, Bicer, Fuat, Ozer, Ahmet, Grimberg, Kerry O, Bakhautdin, Bakytzhan, Sakalar, Cagri, Tasdemir, Cemal, Tuohy, Vincent K

“…The pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is poorly understood. Inflammatory and autoimmune mechanisms may play a role…”
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Autoimmune Targeted Disruption of the Pituitary-Ovarian Axis Causes Premature Ovarian Failure by Altuntas, Cengiz Z, Johnson, Justin M, Tuohy, Vincent K

“…Premature ovarian failure (POF) is characterized by amenorrhea and high serum levels of follicle-stimulating hormone (FSH). POF causes female infertility and…”
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Experimental autoimmune breast failure: a model for lactation insufficiency, postnatal nutritional deprivation, and prophylactic breast cancer vaccination by Kesaraju, Pavani, Jaini, Ritika, Johnson, Justin M, Altuntas, Cengiz Z, Gruden, Jessica J, Sakalar, Cagri, Tuohy, Vincent K

“…Mastitis is a substantial clinical problem in lactating women that may result in severe pain and abrupt termination of breastfeeding, thereby predisposing…”
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Increased Frequencies of Cochlin-Specific T Cells in Patients with Autoimmune Sensorineural Hearing Loss by Baek, Moo-Jin, Park, Hyun-Min, Johnson, Justin M, Altuntas, Cengiz Z, Jane-wit, Daniel, Jaini, Ritika, Solares, C. Arturo, Thomas, Dawn M, Ball, Edward J, Robertson, Nahid G, Morton, Cynthia C, Hughes, Gordon B, Tuohy, Vincent K

“…Autoimmune sensorineural hearing loss (ASNHL) is the most common cause of sudden hearing loss in adults. Although autoimmune etiopathogenic events have long…”
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