Search Results - "Altuǧ, Sedat"

Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts by Altuǧ, Sedat, Demiryürek, A Tuncay, Kane, Kathleen A, Kanzik, İlker

“…The aim of this study was to investigate the involvement of peroxynitrite, reactive metabolite originating from nitric oxide and superoxide, in preconditioning…”
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Protective effects of poly (adp-ribose) synthase inhibitors on digoxin-induced cardiotoxicity in guinea-pig isolated hearts by Tuncay Demiryürek, A, Yildiz, Gülüzar, Eşiyok, Sibel, Altuğ, Sedat

“…Reactive oxygen species, generated and released during digoxin-induced cardiotoxicity, can produce an activation of poly (ADP-ribose) synthase (PARS). Our…”
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Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial by Sezer, Zafer, Inal, Ahmet, Cinar, Salih L., Mazicioglu, Mustafa M., Altug, Sedat, Karasulu, Hatice Y., Diril, Mine, Mehmetoglu Al, Ayca, Kozlu, Serhat, Ulu, Nadir

“…Introduction Psoriasis is a common skin disorder associated with physical and psychological burdens. Visible disfiguration can trigger a negative reaction…”
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Effects of econazole on receptor-operated and depolarization-induced contractions in rat isolated aorta by Tunçtan, Bahar, Altuğ, Sedat, Uludağ, Orhan, Abacioğlu, Nurettin

“…In our previous study, econazole caused a decrease in serum nitrite levels in septic mice in vivo, but it enhanced the mortality rate. The aim of the study was…”
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Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer by Paz-Ares, Luis G, Altug, Sedat, Vaury, Alexandra Thareau, Jaime, Jesús Corral, Russo, Francesca, Visseren-Grul, Carla

“…To improve the efficacy of first-line therapy for advanced non-small cell lung cancer (NSCLC), additional maintenance chemotherapy may be given after initial…”
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Temporal variation in serum nitrite levels in rats and mice by Uludağ, O, Tunçtan, B, Güney, H Z, Uluoğlu, C, Altuğ, S, Zengil, H, Abacioğlu, N

“…Although considerable evidence implicates involvement of nitric oxide (NO) in circadian regulation, little is known about possible 24 h variations in basal NO…”
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Smoking and prognostic factors in an observational setting in patients with advanced non-small cell lung carcinoma by Li, Chien-Te, Marek, Magdalena, Guclu, Salih Z, Kim, Younseup, Meshref, Mohamed, Qin, Shukui, Kadziola, Zbigniew, Krejcy, Kurt, Altug, Sedat

“…This prospective observational study estimated the effect of prognostic factors, particularly continued smoking during therapy, on survival in advanced…”
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Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotinib to either pemetrexed or erlotinib alone as second-line treatment for never-smokers with non-squamous non-small cell lung cancer by Lee, Dae Ho, Lee, Jung Shin, Kim, Sang-We, Rodrigues-Pereira, José, Han, Baohui, Song, Xiang-Qun, Wang, Jie, Kim, Hoon-Kyo, Sahoo, Tarini Prasad, Digumarti, Raghunadharao, Wang, Xin, Altug, Sedat, Orlando, Mauro

“…Abstract Background This randomised controlled phase 2 study compared pemetrexed and erlotinib in combination with either agent alone in terms of efficacy and…”
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First-line pemetrexed plus cisplatin followed by gefitinib maintenance therapy versus gefitinib monotherapy in East Asian patients with locally advanced or metastatic non-squamous non-small cell lung cancer: A randomised, phase 3 trial by Yang, James Chih-Hsin, Kang, Jin Hyoung, Mok, Tony, Ahn, Myung-Ju, Srimuninnimit, Vichien, Lin, Chia-Chi, Kim, Dong-Wan, Tsai, Chun-Ming, Barraclough, Helen, Altug, Sedat, Orlando, Mauro, Park, Keunchil

“…Abstract Background In the Iressa Pan-ASia Study (IPASS), gefitinib claimed improved progression-free survival (PFS) versus carboplatin-paclitaxel in…”
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A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Psoriasis by Engin, Burhan, Güler Özden, Müge, Karstarlı Bakay, Özge Sevil, Kartal, Selda Pelin, Zindancı, İlkin, Çınar, Salih Levent, Dursun, Recep, Pehlivan Ulutaş, Gizem, Özkök Akbulut, Tuğba Özkök, Hapa, Fatma Aslı, Bülbül Başkan, Emel, Melikoğlu, Mehmet, Polat Ekinci, Algün, Demirel Öğüt, Neslihan, Hızlı, Pelin, Türkoğlu, Zafer, Küçük, Özlem Su, Topkarcı, Zeynep, Türsen, Ümit, Canpolat, Filiz, Uçgun, Hanife, Yaşar, Şirin, Temiz, Selami Aykut, Doğramacı, Asena Çiğdem, Altuğ, Sedat, Kozlu, Serhat, Ulu, Nadir, Serdaroğlu, Server

“…Topical therapies are used in almost all patients with psoriasis. A novel fixed topical combination cream (GN-037) with a lower concentration (0.0356%) of…”
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The beneficial effects of peroxynitrite on ischaemia–reperfusion arrhythmias in rat isolated hearts by ALTUG, S, DEMIRYÜREK, A. T, CAKICI, I, KANZIK, I

“…The simultaneous production of nitric oxide (NO) and superoxide leads to the formation of a potent toxic metabolite peroxynitrite (ONOO −). However, ONOO − at…”
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Patient attitudes towards chemotherapy and survival: A prospective observational study in advanced non-small cell lung cancer by Chu, Da-Tong, Kim, Sang-We, Hsu, Hon-Ki, Çok, Gürsel, Roubec, Jaromir, Patil, Shekhar, Damyanov, Danail, West, Teena, Hall, Belinda, Altug, Sedat

“…Abstract This multicenter, non-interventional, prospective, observational study aimed to determine whether patients’ attitude to chemotherapy is an independent…”
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Twenty-four-hour variation of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model by Uludag, Orhan, Tunctan, Bahar, Altug, Sedat, Zengil, Hakan, Abacioglu, Nurettin

“…The L-arginine/nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway is known to be involved in central and peripheral nociceptive processes. This…”
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Patient attitudes towards chemotherapy as assessed by patient versus physician: A prospective observational study in advanced non-small cell lung cancer by Chu, Da-Tong, Kim, Sang-We, Kuo, Han-Pin, Ozacar, Rifat, Salajka, Frantisek, Krishnamurthy, S, Damyanov, Danail, Altug, Sedat, Reece, William H.H, Wang, Li

“…Summary Background In the treatment of advanced cancer, a physician's ability to accurately identify a patient's attitude towards treatment is critical. This…”
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Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis by Tunçtan, Bahar, Altug, Sedat, Uludag, Orhan, Demirkay, Beray, Abacioglu, Nurettin

“…The effects of selective ((5,5-dimethyl-3-(3-florophenyl)-4-(4-methylsulphonyl-2(5 H)-furanon); DFU) and (…”
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EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITION IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS IN MICE by TUNÇTAN, BAHAR, ULUDA Ǧ, ORHAN, ALTU Ǧ, SEDAT, ABACIO Ǧ, NURETTIN

“…In the present study, we have investigated the effects of nitric oxide (NO) synthase inhibition on mortality in lipopolysaccharide (LPS)-induced sepsis in…”
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Biological time-dependent difference in effect of peroxynitrite demonstrated by the mouse hot plate pain model by Altug, Sedat, Uludag, Orhan, Tunctan, Bahar, Cakici, Iclal, Zengil, Hakan, Abacioglu, Nurettin

“…We previously demonstrated the rhythmic pattern of L-arginine/nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) cascade in nociceptive processes. The…”
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Time-Dependent Variations in Serum Nitrite, 6-Keto-Prostaglandin F 1α and Thromboxane B 2 Levels Induced by Lipopolysaccharide in Mice by Tunçtan, Bahar, Altuğ, Sedat, Uludağ, Orhan, Abacioğlu, Nurettin

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Time-Dependent Variations in Serum Nitrite, 6-Keto-Prostaglandin F1α and Thromboxane B2 Levels Induced by Lipopolysaccharide in Mice by Tunçtan, Bahar, Altuğ, Sedat, Uludağ, Orhan, Abacioğlu, Nurettin

“…Clinical features of certain immuno-inflammatory disorders exhibit time-dependent fluctuations, which could be related to circadian rhythmicity of…”
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The Role of Nitric Oxide in Digoxin‐Induced Arrhythmias in Guinea‐Pigs by ALTUG, S, UZUN, Ö, DEMIRYÜREK, A. T, CAKICI, I, ABACIOGLU, N, KANZIK, I

“…: We have investigated the effects of nitric oxide synthase inhibitor (L‐NAME), nitric oxide precursor (L‐arginine) and nitric oxide donor (sodium…”
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