Search Results - "Altschuler, Richard"

Transient peripheral vestibular hypofunction measured with vestibular short-latency evoked potentials following noise exposure in rats by Stewart, Courtney E, Bauer, David S, Altschuler, Richard A, King, William Michael

“…Exposure to 120 dB sound pressure level (SPL) band-limited noise results in delayed onset latency and reduced vestibular short-latency evoked potential (VsEP)…”
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Ototoxicity-related changes in GABA immunolabeling within the rat inferior colliculus by Holt, Avril Genene, Griffith, Ronald D., Lee, Soo D., Asako, Mikiya, Buras, Eric, Yalcinoglu, Selin, Altschuler, Richard A.

“…•GABA labeled somata in the CNIC are larger and less round than unlabeled somata.•Labeling intensity decreased in somata and the neuropil of the CNIC after…”
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Editorial: Bilateral vestibulopathy by Stewart, Courtney, King, William Michael, Altschuler, Richard, McCaslin, Devin

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Small Arms Fire-like noise: Effects on Hearing Loss, Gap Detection and the Influence of Preventive Treatment by Altschuler, Richard A., Halsey, Karin, Kanicki, Ariane, Martin, Cathy, Prieskorn, Diane, DeRemer, Susan, Dolan, David F.

“…•Small arms fire-like noise induced loss of inner hair cell synaptic ribbons in rat cochleae.•Small arms fire-like noise also reduced Gap Detection many…”
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Effects of Noise Exposure on the Vestibular System: A Systematic Review by Stewart, Courtney Elaine, Holt, Avril Genene, Altschuler, Richard A, Cacace, Anthony Thomas, Hall, Courtney D, Murnane, Owen D, King, W Michael, Akin, Faith W

“…Despite our understanding of the impact of noise-induced damage to the auditory system, much less is known about the impact of noise exposure on the vestibular…”
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Vestibular short-latency evoked potential abolished by low-frequency noise exposure in rats by Stewart, Courtney E, Kanicki, Ariane C, Altschuler, Richard A, King, W M

“…The vestibular system plays a critical role in detection of head movements and is essential for normal postural control. Because of their anatomical proximity…”
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Noise overstimulation of young adult UMHET4 mice accelerates age-related hearing loss by Altschuler, Richard A, Stewart, Courtney E., Kabara, Lisa, Martin, Catherine A., Kanicki, Ariane, Kohrman, David C., Dolan, David F.

“…•A single exposure to noise given to young mice that does not cause immediate permanent hearing loss will accelerate and enhance later age-related hearing…”
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Rapamycin Added to Diet in Late Mid-Life Delays Age-Related Hearing Loss in UMHET4 Mice by Altschuler, Richard A, Kabara, Lisa, Martin, Catherine, Kanicki, Ariane, Stewart, Courtney E, Kohrman, David C, Dolan, David F

“…Our previous study demonstrated rapamycin added to diet at 4 months of age had significantly less age-related outer hair cell loss in the basal half of the…”
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Structure and innervation of the cochlea by Raphael, Yehoash, Altschuler, Richard A

“…The role of the cochlea is to transduce complex sound waves into electrical neural activity in the auditory nerve. Hair cells of the organ of Corti are the…”
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Balance beam crossing times are slower after noise exposure in rats by Bartikofsky, Dylan, Hertz, Mikayla Jade, Bauer, David S, Altschuler, Richard, King, W Michael, Stewart, Courtney Elaine

“…The vestibular system integrates signals related to vision, head position, gravity, motion, and body position to provide stability during motion through the…”
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Treatment with Piribedil and Memantine Reduces Noise-Induced Loss of Inner Hair Cell Synaptic Ribbons by Altschuler, Richard A., Wys, Noel, Prieskorn, Diane, Martin, Cathy, DeRemer, Susan, Bledsoe, Sanford, Miller, Josef M.

“…Noise overstimulation can induce loss of synaptic ribbons associated with loss of Inner Hair Cell – Auditory Nerve synaptic connections. This study examined if…”
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Exposure to Intense Noise Causes Vestibular Loss by Stewart, Courtney E, Kanicki, Ariane C, Bauer, David S, Altschuler, Richard A, King, W Michael

“…ABSTRACT Introduction The vestibular system is essential for normal postural control and balance. Because of their proximity to the cochlea, the otolith organs…”
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OTO-104: a sustained-release dexamethasone hydrogel for the treatment of otic disorders by Piu, Fabrice, Wang, Xiaobo, Fernandez, Rayne, Dellamary, Luis, Harrop, Anne, Ye, Qiang, Sweet, Jenifer, Tapp, Rachel, Dolan, David F, Altschuler, Richard A, Lichter, Jay, LeBel, Carl

“…To investigate whether OTO-104, a poloxamer-based hydrogel containing micronized dexamethasone for intratympanic delivery, can provide long-lasting inner ear…”
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Glutamatergic Neuronal Differentiation of Mouse Embryonic Stem Cells after Transient Expression of Neurogenin 1 and Treatment with BDNF and GDNF: In Vitro and In Vivo Studies by Reyes, Jeannie H, O'Shea, K. Sue, Wys, Noel L, Velkey, J. Matthew, Prieskorn, Diane M, Wesolowski, Karolina, Miller, Josef M, Altschuler, Richard A

“…Differentiation of the pluripotent neuroepithelium into neurons and glia is accomplished by the interaction of growth factors and cell-type restricted…”
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Persistence, distribution, and impact of distinctly segmented microparticles on cochlear health following in vivo infusion by Ross, Astin M., Rahmani, Sahar, Prieskorn, Diane M., Dishman, Acacia F., Miller, Josef M., Lahann, Joerg, Altschuler, Richard A.

“…Delivery of pharmaceuticals to the cochleae of patients with auditory dysfunction could potentially have many benefits from enhancing auditory nerve survival…”
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OTO-201: Nonclinical Assessment of a Sustained-Release Ciprofloxacin Hydrogel for the Treatment of Otitis Media by Wang, Xiaobo, Fernandez, Rayne, Tsivkovskaia, Natalia, Harrop-Jones, Anne, Hou, Huiying J, Dellamary, Luis, Dolan, David F, Altschuler, Richard A, LeBel, Carl, Piu, Fabrice

“…HYPOTHESISOTO-201 can provide sustained release to the middle ear and effectively treat otitis media, when compared with FDA-approved ciprofloxacin otic drop…”
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Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: Effects of brain-derived neurotrophic factor and fibroblast growth factor by Miller, Josef M., Le Prell, Colleen G., Prieskorn, Diane M., Wys, Noel L., Altschuler, Richard A.

“…The extent to which neurotrophic factors are able to not only rescue the auditory nerve from deafferentation‐induced degeneration but also promote process…”
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Dual Release Carriers for Cochlear Delivery by Rahmani, Sahar, Ross, Astin M., Park, Tae-Hong, Durmaz, Hakan, Dishman, Acacia F., Prieskorn, Diane M., Jones, Nathan, Altschuler, Richard A., Lahann, Joerg

“…The fabrication of a carrier system capable of selectively encapsulating two therapeutics, piribedil and glial cell derived neurotrophic factor, in select…”
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Age-related auditory pathology in the CBA/J mouse by Sha, Su-Hua, Kanicki, Ariane, Dootz, Gary, Talaska, Andra E., Halsey, Karin, Dolan, David, Altschuler, Richard, Schacht, Jochen

“…Commercially obtained aged male CBA/J mice presented a complex pattern of hearing loss and morphological changes. A significant threshold shift in auditory…”
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Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea by Ohinata, Yoshimitsu, Miller, Josef M., Altschuler, Richard A., Schacht, Jochen

“…This study investigates the correlation between the formation of reactive oxygen species (ROS) and auditory damage in noise-induced hearing loss. The noise…”
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