Search Results - "Alton, K B"

Spitzer + VLTI-GRAVITY Measure the Lens Mass of a Nearby Microlensing Event by Zang, Weicheng, Dong, Subo, Gould, Andrew, Calchi Novati, Sebastiano, Chen, Ping, Yang, Hongjing, Li, Shun-Sheng, Mao, Shude, Alton, K. B., Brimacombe, J., Carey, Sean, Christie, G. W., Delplancke-Ströbele, F., Feliz, Dax L., Gaudi, B. Scott, Green, J., Hu, Shaoming, Jayasinghe, T., Koff, R. A., Kurtenkov, A., Mérand, A., Minev, Milen, Mutel, Robert, Natusch, T., Roth, Tyler, Shvartzvald, Yossi, Sun, Fengwu, Vanmunster, T., Zhu, Wei

“…We report the lens mass and distance measurements of the nearby microlensing event TCP J05074264+2447555 (Kojima-1). We measure the microlens parallax vector…”
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Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663 by Van Heek, Margaret, Farley, Constance, Compton, Douglas S, Hoos, Lizbeth, Alton, Kevin B, Sybertz, Edmund J, Davis, Harry R

“…Previous studies described the metabolism‐based discovery of a potent, selective inhibitor of intestinal absorption of cholesterol, SCH58235 (Ezetimibe). Here…”
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Disposition of desloratadine in healthy volunteers by Ramanathan, R., Reyderman, L., Su, A.-D., Alvarez, N., Chowdhury, S. K., Alton, K. B., Wirth, M. A., Clement, R. P., Statkevich, P., Patrick, J. E.

“…The absorption, metabolism and excretion of desloratadine (DL, Clarinex®) were characterized in six healthy male volunteers. Subjects received a single oral…”
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The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs by Davis, Harry R., Pula, Kathyrn K., Alton, Kevin B., Burrier, Robert E., Watkins, Robert W.

“…Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma cholesterol levels in…”
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Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist by Ghosal, A., Chowdhury, S. K., Gupta, S., Yuan, Y., Iannucci, R., Zhang, H., Zbaida, S., Patrick, J. E., Alton, K. B.

“…The identification and relative contribution of human cytochrome P450 enzyme(s) involved in the metabolism of SCH 351125 were investigated. In human liver…”
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An LC/MS/MS method for the quantitation of MTIC (5-(3- N-methyltriazen-1-yl)-imidazole-4-carboxamide), a bioconversion product of temozolomide, in rat and dog plasma by Chowdhury, S.K., Laudicina, D., Blumenkrantz, N., Wirth, M., Alton, K.B.

“…A sensitive and selective HPLC/electrospray ionization tandem mass spectrometric (LC/ESI/MS/MS) method for the quantitative determination of MTIC (5-(3-…”
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Ezetimibe : A review of its metabolism, pharmacokinetics and drug interactions by KOSOGLOU, Teddy, STATKEVICH, Paul, JOHNSON-LEVONAS, Amy O, PAOLINI, John F, BERGMAN, Arthur J, ALTON, Kevin B

“…Ezetimibe is the first lipid-lowering drug that inhibits intestinal uptake of dietary and biliary cholesterol without affecting the absorption of fat-soluble…”
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Disposition of loratadine in healthy volunteers by Ramanathan, R., Reyderman, L., Kulmatycki, K., Su, A.-D., Alvarez, N., Chowdhury, S. K., Alton, K. B., Wirth, M. A., Clement, R. P., Statkevich, P., Patrick, J. E.

“…The absorption, metabolism and excretion of carbon-14-labeled loratadine (LOR, SCH 29851, Claritin®) administered orally to healthy male volunteers were…”
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Urinary metabolites of (R),(R)-labetalol by Alton, K B, Chan, T M, Pramanik, B N

“…Dilevalol, the (R),(R)-isomer of labetalol, is a novel antihypertensive agent with both beta-adrenoreceptor activity and direct vasodilatory action. The…”
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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 by Van Heek, M, France, C F, Compton, D S, McLeod, R L, Yumibe, N P, Alton, K B, Sybertz, E J, Davis, Jr, H R

“…SCH48461 is a selective and highly potent inhibitor of cholesterol absorption. In rats, SCH48461 is rapidly and completely metabolized in the first pass…”
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Identification of two novel indolic metabolites of (R),(R)-labetalol in monkey urine by Alton, K B, Chan, T M, Pramanik, B

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Fragmentation of N-oxides (deoxygenation) in atmospheric pressure ionization: Investigation of the activation process by Tong, Wei, Chowdhury, Swapan K., Chen, Jin-Chang, Zhong, Ruyun, Alton, Kevin B., Patrick, James E.

“…The diagnostic fragmentation of N‐oxides resulting from loss of the oxygen atom (MH+ → MH+‐O) in electrospray and atmospheric pressure chemical ionization…”
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High-performance liquid chromatographic assay for labetalol in human plasma using a PRP-1 column and fluorometric detection by Alton, K B, Leitz, F, Bariletto, S, Jaworsky, L, Desrivieres, D, Patrick, J

“…A high-performance liquid chromatographic assay for the determination of labetalol, a novel antihypertensive agent, in human plasma was developed…”
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Determination of the antifungal agent, ketoconazole, in human plasma by high-performance liquid chromatography by Alton, K B

“…A rapid and selective high-performance liquid chromatographic (HPLC) assay for the quantitative determination of ketoconazole, an orally active antifungal…”
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Spitzer + VLTI-GRAVITY Measure the Lens Mass of a Nearby Microlensing Event by Zang, Weicheng, Dong, Subo, Gould, Andrew, Novati, Sebastiano Calchi, Chen, Ping, Yang, Hongjing, Li, Shun-Sheng, Mao, Shude, Alton, K. B, Carey, Sean, Christie, G. W, Delplancke-Ströbele, F, Feliz, Dax L, Green, J, Hu, Shaoming, Jayasinghe, T, Koff, R. A, Kurtenkov, A, Mérand, A, Minev, Milen, Mutel, Robert, Natusch, T, Roth, Tyler, Shvartzvald, Yossi, Sun, Fengwu, Vanmunster, T, Zhu, Wei

“…We report the lens mass and distance measurements of the nearby microlensing event TCP J05074264+2447555. We measure the microlens parallax vector ${\pi}_{\rm…”
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High-performance liquid chromatographic assay for hydrochlorothiazide in human urine by Alton, K B, Desrivieres, D, Patrick, J E

“…A high-performance liquid chromatographic assay was developed for the quantitative determination of hydrochlorothiazide (HCT) in human urine. Reversed-phase…”
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Biotransformation of a 1,5-benzodiazepine, triflubazam, by man by Alton, K B, Grimes, R M, Shaw, C, Patrick, J E, McGuire, J L

“…The biotransformation of triblubazam (ORF 8063; 1-methyl-5-phenyl-7-trifluoromethyl-1H-1,5-benzodiazepin-2,4-[3H,5H]-dione) was studied in man. Seven male…”
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Comparative biotransformation of triflubazam in rats, dogs, and monkeys by Alton, K B, Patrick, J E, Shaw, C, McGuire, J L

“…The biotransformation of 14C-triflubazam (ORF 8063; 1-methyl-5-phenyl-7-trifluoromethyl-1H-1,5-benzodiazepin-2-4-[3H,5H]-dione) was investigated in rats, dogs,…”
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Disposition of 14C-eptifibatide after intravenous administration to healthy men by Alton, Kevin B., Kosoglou, Teddy, Baker, Susan, Affrime, Melton B., Cayen, Mitchell N., Patrick, James E.

“…Eptifibatide, a synthetic peptide inhibitor of the platelet glycoprotein IIb/IIIa receptor, has been studied as an antithrombotic agent in a variety of acute…”
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High-performance liquid chromatographic assay for suprofen, a potent new analgesic, in plasma by Alton, K B, Patrick, J E

“…A simple, rapid, high-performance liquid chromatographic (HPLC) determination of therapeutic levels of suprofen, a potent new analgesic, in human plasma is…”
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