Search Results - "Altomare, A."

Perturbations of the AKT signaling pathway in human cancer by Altomare, Deborah A, Testa, Joseph R

“…AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate…”
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Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling by Altomare, D A, Khaled, A R

“…The AKT family of serine threonine kinases is of critical importance with regard to growth factor signaling, cell proliferation, survival and oncogenesis…”
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PD-L1 blockade enhances anti-tumor efficacy of NK cells by Oyer, Jeremiah L., Gitto, Sarah B., Altomare, Deborah A., Copik, Alicja J.

“…Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited to ~ 15% of patients with lymphocyte infiltrated, PD-L1…”
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Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation by Arnoletti, Juan Pablo, Reza, Joseph, Rosales, Armando, Monreal, Alberto, Fanaian, Na'im, Whisner, Suzanne, Srivastava, Milan, Rivera-Otero, Julia, Yu, Gongxin, Phanstiel Iv, Otto, Altomare, Deborah A, Tran, Quang, Litherland, Sally A

“…The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of…”
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Pharmacokinetic profile of bilberry anthocyanins in rats and the role of glucose transporters: LC–MS/MS and computational studies by Baron, G., Altomare, A., Regazzoni, L., Redaelli, V., Grandi, S., Riva, A., Morazzoni, P., Mazzolari, A., Carini, M., Vistoli, G., Aldini, G.

“…•A LC-ESI–MS method for anthocyanins identification and quantitation in plasma was set-up and validated.•15 bilberry anthocyanins behave differently in term of…”
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Development and validation of a LC–MS/MS assay for quantification of cisplatin in rat plasma and urine by Shaik, Abdul Naveed, Altomare, Deborah A., Lesko, Lawrence J., Trame, Mirjam N.

“…•Cisplatin LC–MS/MS Method Validation using Agilent 6460 triple quad.•Derivatization of cisplatin with diethyldithiocarbamate for indirect estimation of…”
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Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett’s Tumorigenesis by Bernard, Joshua N., Chinnaiyan, Vikram, Andl, Thomas, Le Bras, Gregoire F., Qureshi, M. Nasar, Altomare, Deborah A., Andl, Claudia D.

“…Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett’s Esophagus (BE) and the progression to esophageal…”
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Cryopreserved PM21-Particle-Expanded Natural Killer Cells Maintain Cytotoxicity and Effector Functions In Vitro and In Vivo by Oyer, Jeremiah L, Croom-Perez, Tayler J, Dieffenthaller, Thomas A, Robles-Carillo, Liza D, Gitto, Sarah B, Altomare, Deborah A, Copik, Alicja J

“…There is a great interest in developing natural killer (NK) cells as adoptive cancer immunotherapy. For off-the-shelf approaches and to conduct multicenter…”
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Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment by Nakkina, Sai Preethi, Gitto, Sarah B, Pandey, Veethika, Parikh, Jignesh G, Geerts, Dirk, Maurer, Hans Carlo, Olive, Kenneth P, Phanstiel, 4th, Otto, Altomare, Deborah A

“…Pancreatic cancer is the fourth leading cause of cancer death. Existing therapies only moderately improve pancreatic ductal adenocarcinoma (PDAC) patient…”
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RAD001 Inhibits Human Ovarian Cancer Cell Proliferation, Enhances Cisplatin-Induced Apoptosis, and Prolongs Survival in an Ovarian Cancer Model by Mabuchi, Seiji, Altomare, Deborah A, Cheung, Mitchell, Zhang, Lili, Poulikakos, Poulikos I, Hensley, Harvey H, Schilder, Russell J, Ozols, Robert F, Testa, Joseph R

“…Purpose: mTOR (mammalian target of rapamycin) plays a central role in regulating cell growth and cell cycle progression and is regarded as a promising…”
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Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins by Baron, G., Altomare, A., Della Vedova, L., Gado, F., Quagliano, O., Casati, S., Tosi, N., Bresciani, L., Del Rio, D., Roda, G., D'Amato, A., Lammi, C., Macorano, A., Vittorio, S., Vistoli, G., Fumagalli, L., Carini, M., Leone, A., Marino, M., Del Bo’, C., Miotto, G., Ursini, F., Morazzoni, P., Aldini, G.

“…Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units…”
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DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment by Nakkina, Sai Preethi, Gitto, Sarah B, Beardsley, Jordan M, Pandey, Veethika, Rohr, Michael W, Parikh, Jignesh G, Phanstiel, 4th, Otto, Altomare, Deborah A

“…Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor five-year survival rate of less than 10%. Immune suppression along with chemoresistance are…”
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mTOR Is a Promising Therapeutic Target Both in Cisplatin-Sensitive and Cisplatin-Resistant Clear Cell Carcinoma of the Ovary by MABUCHI, Seiji, KAWASE, Chiaki, OHMICHI, Masahide, TESTA, Joseph R, KIMURA, Tadashi, ALTOMARE, Deborah A, MORISHIGE, Kenichirou, SAWADA, Kenjiro, HAYASHI, Masami, TSUJIMOTO, Masahiko, YAMOTO, Mareo, KLEIN-SZANTO, Andres J, SCHILDER, Russell J

“…Purpose: Mammalian target of rapamycin (mTOR) plays a central role in cell proliferation and is regarded as a promising target in cancer therapy, including for…”
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Reactive Carbonyl Species and Protein Adducts: Identification Strategies, Biological Mechanisms and Molecular Approaches for Their Detoxification by Aldini, Giancarlo, Altomare, Alessandra A

“…The Special issue is composed of 13 contributions: 9 research papers and 4 reviews [...]…”
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FAS-Associated Factor 1 (FAF1): Diverse functions and implications for oncogenesis by Menges, Craig W., Altomare, Deborah A., Testa, Joseph R.

“…FAS-associated factor 1, FAF1, is an evolutionarily conserved protein that has several protein interaction domains.  Although FAF1 was initially identified as…”
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PM21-particle stimulation augmented with cytokines enhances NK cell expansion and confers memory-like characteristics with enhanced survival by Oyer, Jeremiah L, Croom-Perez, Tayler J, Hasan, Md Faqrul, Rivera-Huertas, Javier A, Gitto, Sarah B, Mucha, Joanna M, Zhu, Xiang, Altomare, Deborah A, Igarashi, Robert Y, Copik, Alicja J

“…NK cell therapeutics have gained significant attention as a potential cancer treatment. Towards therapeutic use, NK cells need to be activated and expanded to…”
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Human serum albumin cysteinylation is increased in end stage renal disease patients and reduced by hemodialysis: mass spectrometry studies by Regazzoni, L, Del Vecchio, L, Altomare, A, Yeum, K-J, Cusi, D, Locatelli, F, Carini, M, Aldini, G

“…The aim of the present work was to monitor the covalent modifications of human serum albumin (HSA) in end stage renal diseases (ESRD) non-diabetic patients,…”
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Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis by Altomare, Deborah A, Menges, Craig W, Xu, Jinfei, Pei, Jianming, Zhang, Lili, Tadevosyan, Ara, Neumann-Domer, Erin, Liu, Zemin, Carbone, Michele, Chudoba, Ilse, Klein-Szanto, Andres J, Testa, Joseph R

“…The CDKN2A/ARF locus encompasses overlapping tumor suppressor genes p16(INK4A) and p14(ARF), which are frequently co-deleted in human malignant mesothelioma…”
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Phase II Study of Erlotinib in Patients With Malignant Pleural Mesothelioma: A Southwest Oncology Group Study by GARLAND, Linda L, RANKIN, Cathryn, GANDARA, David R, RIVKIN, Saul E, SCOTT, Katherine M, NAGLE, Raymond B, KLEIN-SZANTO, Andres J. P, TESTA, Joseph R, ALTOMARE, Deborah A, BORDEN, Ernest C

“…Malignant pleural mesothelioma (MPM) expresses high levels of epidermal growth factor receptor (EGFR), and preclinical studies have identified antitumor…”
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Ag2WO4 as a multifunctional material: Fundamentals and progress of an extraordinarily versatile semiconductor by Gouveia, A.F., Roca, R.A., Macedo, N.G., Cavalcante, L.S., Longo, E., San-Miguel, M.A., Altomare, A., da Silva, G.S., Andrés, J.

“…Silver tungstate (Ag2WO4) based materials are intensively studied because of their unique chemical and physical properties. Ag2WO4 polymorphs present discrete…”
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