Search Results - "Altmeppen, Hermann C"

Diverse functions of the prion protein – Does proteolytic processing hold the key? by Linsenmeier, Luise, Altmeppen, Hermann C., Wetzel, Sebastian, Mohammadi, Behnam, Saftig, Paul, Glatzel, Markus

“…Proteolytic processing of the cellular and disease-associated form of the prion protein leads to generation of bioactive soluble prion protein fragments and…”
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GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice by Puig, Berta, Altmeppen, Hermann C, Linsenmeier, Luise, Chakroun, Karima, Wegwitz, Florian, Piontek, Ulrike K, Tatzelt, Jörg, Bate, Clive, Magnus, Tim, Glatzel, Markus

“…The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical…”
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Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection by Karner, Dubravka, Kvestak, Daria, Kucan Brlic, Paola, Cokaric Brdovcak, Maja, Lisnic, Berislav, Brizic, Ilija, Juranic Lisnic, Vanda, Golemac, Mijo, Tomac, Jelena, Krmpotic, Astrid, Karkeni, Esma, Libri, Valentina, Mella, Sebastien, Legname, Giuseppe, Altmeppen, Hermann C., Hasan, Milena, Jonjic, Stipan, Lenac Rovis, Tihana

“…Cytomegalovirus (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells…”
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Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake by Brenna, Santra, Altmeppen, Hermann C., Mohammadi, Behnam, Rissiek, Björn, Schlink, Florence, Ludewig, Peter, Krisp, Christoph, Schlüter, Hartmut, Failla, Antonio Virgilio, Schneider, Carola, Glatzel, Markus, Puig, Berta, Magnus, Tim

“…Extracellular vesicles (EVs) are important means of intercellular communication and a potent tool for regenerative therapy. In ischaemic stroke, transient…”
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Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein by Linsenmeier, Luise, Mohammadi, Behnam, Wetzel, Sebastian, Puig, Berta, Jackson, Walker S, Hartmann, Alexander, Uchiyama, Keiji, Sakaguchi, Suehiro, Endres, Kristina, Tatzelt, Jörg, Saftig, Paul, Glatzel, Markus, Altmeppen, Hermann C

“…Keywords: ADAM10, Antibody, Exosomes, Glycosylation, Membrane anchor, Neurodegeneration, Prion protein, Proteolytic cleavage, Shedding…”
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The sheddase ADAM10 is a potent modulator of prion disease by Altmeppen, Hermann C, Prox, Johannes, Krasemann, Susanne, Puig, Berta, Kruszewski, Katharina, Dohler, Frank, Bernreuther, Christian, Hoxha, Ana, Linsenmeier, Luise, Sikorska, Beata, Liberski, Pawel P, Bartsch, Udo, Saftig, Paul, Glatzel, Markus

“…The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc)…”
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α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies by Schmitz, Matthias, Candelise, Niccolò, Canaslan, Sezgi, Altmeppen, Hermann C, Matschke, Jakob, Glatzel, Markus, Younas, Neelam, Zafar, Saima, Hermann, Peter, Zerr, Inga

“…α-Synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases…”
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Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts by Matamoros-Angles, Andreu, Mohammadi, Behnam, Song, Feizhi, Shafiq, Mohsin, Brenna, Santra, Puig, Berta, Glatzel, Markus, Altmeppen, Hermann

“…In the last decades, the role of the prion protein (PrP) in neurodegenerative diseases has been intensively investigated, initially in prion diseases of humans…”
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Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice by Puig, Berta, Altmeppen, Hermann C., Ulbrich, Sarah, Linsenmeier, Luise, Krasemann, Susanne, Chakroun, Karima, Acevedo-Morantes, Claudia Y., Wille, Holger, Tatzelt, Jörg, Glatzel, Markus

“…Misfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrP C ) is a…”
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Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo by Altmeppen, Hermann C, Prox, Johannes, Puig, Berta, Kluth, Mark A, Bernreuther, Christian, Thurm, Dana, Jorissen, Ellen, Petrowitz, Bettina, Bartsch, Udo, De Strooper, Bart, Saftig, Paul, Glatzel, Markus

“…The cellular prion protein (PrPC) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to…”
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Misfolding leads the way to unraveling signaling pathways in the pathophysiology of prion diseases by Puig, Berta, Altmeppen, Hermann C., Glatzel, Markus

“…A misfolded version of the prion protein represents an essential component in the pathophysiology of fatal neurodegenerative prion diseases, which affect…”
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N-Glycans and Glycosylphosphatidylinositol-Anchor Act on Polarized Sorting of Mouse PrPC in Madin-Darby Canine Kidney Cells by Puig, Berta, Altmeppen, Hermann C., Thurm, Dana, Geissen, Markus, Conrad, Catharina, Braulke, Thomas, Glatzel, Markus

“…The cellular prion protein (PrPC) plays a fundamental role in prion disease. PrPC is a glycosylphosphatidylinositol (GPI)-anchored protein with two variably…”
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N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells by Puig, Berta, Altmeppen, Hermann C, Thurm, Dana, Geissen, Markus, Conrad, Catharina, Braulke, Thomas, Glatzel, Markus

“…The cellular prion protein (PrP(C)) plays a fundamental role in prion disease. PrP(C) is a glycosylphosphatidylinositol (GPI)-anchored protein with two…”
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The SARS-CoV-2 main protease M pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells by Wenzel, Jan, Lampe, Josephine, Müller-Fielitz, Helge, Schuster, Raphael, Zille, Marietta, Müller, Kristin, Krohn, Markus, Körbelin, Jakob, Zhang, Linlin, Özorhan, Ümit, Neve, Vanessa, Wagner, Julian U G, Bojkova, Denisa, Shumliakivska, Mariana, Jiang, Yun, Fähnrich, Anke, Ott, Fabian, Sencio, Valentin, Robil, Cyril, Pfefferle, Susanne, Sauve, Florent, Coêlho, Caio Fernando Ferreira, Franz, Jonas, Spiecker, Frauke, Lembrich, Beate, Binder, Sonja, Feller, Nina, König, Peter, Busch, Hauke, Collin, Ludovic, Villaseñor, Roberto, Jöhren, Olaf, Altmeppen, Hermann C, Pasparakis, Manolis, Dimmeler, Stefanie, Cinatl, Jindrich, Püschel, Klaus, Zelic, Matija, Ofengeim, Dimitry, Stadelmann, Christine, Trottein, François, Nogueiras, Ruben, Hilgenfeld, Rolf, Glatzel, Markus, Prevot, Vincent, Schwaninger, Markus

“…Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small…”
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The prion protein and its ligands: Insights into structure-function relationships by Shafiq, Mohsin, Da Vela, Stefano, Amin, Ladan, Younas, Neelam, Harris, David A, Zerr, Inga, Altmeppen, Hermann C, Svergun, Dmitri, Glatzel, Markus

“…The prion protein is a multifunctional protein that exists in at least two different folding states. It is subject to diverse proteolytic processing steps that…”
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Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression by Heisler, Frank F., Pechmann, Yvonne, Wieser, Ines, Altmeppen, Hermann C., Veenendaal, Leonhard, Muhia, Mary, Schweizer, Michaela, Glatzel, Markus, Krasemann, Susanne, Kneussel, Matthias

“…Cellular prion protein (PrPC) modulates cell adhesion and signaling in the brain. Conversion to its infectious isoform causes neurodegeneration, including…”
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Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo by Gui, Yuqi, Kim, Yohan, Brenna, Santra, Wilmes, Maximilian, Zaghen, Giorgio, Goulbourne, Chris N., Kuchenbecker-Pöls, Lennart, Siebels, Bente, Voß, Hannah, Gocke, Antonia, Schlüter, Hartmut, Schweizer, Michaela, Altmeppen, Hermann C., Magnus, Tim, Levy, Efrat, Puig, Berta

“…Synaptic loss is an early event in the penumbra area after an ischemic stroke. Promoting synaptic preservation in this area would likely improve functional…”
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Influence of Methanol on Prion Reduction during High Temperature and High Pressure Oleochemical Processes by Mohammadi, Behnam, Raudner, Robert, Shafiq, Mohsin, Ahn, Edgar, Altmeppen, Hermann C., Glatzel, Markus

“…Prion‐reduction in standard biodiesel processes is caused by acidic and alkaline conditions. In the alternative RepCat biodiesel process, efficient…”
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Roles of endoproteolytic α‐cleavage and shedding of the prion protein in neurodegeneration by Altmeppen, Hermann C., Prox, Johannes, Puig, Berta, Dohler, Frank, Falker, Clemens, Krasemann, Susanne, Glatzel, Markus

“…The cellular prion protein (PrPC) plays important roles in neurodegenerative diseases. First, it is the well‐established substrate for the conformational…”
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Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions by Aguilar-Calvo, Patricia, Sevillano, Alejandro M., Bapat, Jaidev, Soldau, Katrin, Sandoval, Daniel R., Altmeppen, Hermann C., Linsenmeier, Luise, Pizzo, Donald P., Geschwind, Michael D., Sanchez, Henry, Appleby, Brian S., Cohen, Mark L., Safar, Jiri G., Edland, Steven D., Glatzel, Markus, Nilsson, K. Peter R., Esko, Jeffrey D., Sigurdson, Christina J.

“…Cofactors are essential for driving recombinant prion protein into pathogenic conformers. Polyanions promote prion aggregation in vitro, yet the cofactors that…”
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