Search Results - "Altmann, Daniel M"

COVID-19 vaccination: The road ahead by Altmann, Daniel M, Boyton, Rosemary J

“…A diverse array of successful, first-generation SARS-CoV-2 vaccines have played a huge role in efforts to bring the COVID-19 pandemic under control, even…”
Get full text

What policy makers need to know about COVID-19 protective immunity by Altmann, Daniel M, Douek, Daniel C, Boyton, Rosemary J

“…The route to certainty on the degree and nature of the immunity required for protection will require evidence from formal proofs using approaches such as…”
Get full text

Immunity to SARS-CoV-2 variants of concern by Altmann, Daniel M, Boyton, Rosemary J, Beale, Rupert

“…Variants show variable escape from vaccine immunity, but residual protection may suffice Vaccine candidates based on spike, the glycoprotein that is essential…”
Get full text

The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions? by Boyton, Rosemary J., Altmann, Daniel M.

“…An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission…”
Get full text

Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals by Manisty, Charlotte, Otter, Ashley D, Treibel, Thomas A, McKnight, Áine, Altmann, Daniel M, Brooks, Timothy, Noursadeghi, Mahdad, Boyton, Rosemary J, Semper, Amanda, Moon, James C

“…Rapid vaccine-induced population immunity is a key global strategy to control COVID-19. Vaccination programmes must maximise early impact, particularly with…”
Get full text

Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2 by McDonald, Ian, Murray, Sam M., Reynolds, Catherine J., Altmann, Daniel M., Boyton, Rosemary J.

“…As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to underpin decision-making. We here report a systematic literature review…”
Get full text

Narrating the natural history of live infection by SARS CoV-2 VOC in animal models by Altmann, Daniel M

Get full text

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity by Altmann, Daniel M., Reynolds, Catherine J., Joy, George, Otter, Ashley D., Gibbons, Joseph M., Pade, Corinna, Swadling, Leo, Maini, Mala K., Brooks, Tim, Semper, Amanda, McKnight, Áine, Noursadeghi, Mahdad, Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Boyton, Rosemary J.

“…Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity…”
Get full text

Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis by Negash, Mikias, Chanyalew, Menberework, Girma, Tigist, Alemu, Fekadu, Alcantara, Diana, Towler, Ben, Davey, Gail, Boyton, Rosemary J., Altmann, Daniel M., Howe, Rawleigh, Newport, Melanie J.

“…Available evidences suggest that podoconiosis is triggered by long term exposure of bare feet to volcanic red clay soil particles. Previous genome-wide studies…”
Get full text

Design, recruitment, and microbiological considerations in human challenge studies by Darton, Thomas C, DPhil, Blohmke, Christoph J, Dr, Moorthy, Vasee S, DPhil, Altmann, Daniel M, Prof, Hayden, Frederick G, Prof, Clutterbuck, Elizabeth A, PhD, Levine, Myron M, Prof, Hill, Adrian V S, Prof, Pollard, Andrew J, Prof

“…Summary Since the 18th century a wealth of knowledge regarding infectious disease pathogenesis, prevention, and treatment has been accumulated from findings of…”
Get full text

Antibiotic therapy and outcome from immune-checkpoint inhibitors by Pinato, David J., Gramenitskaya, Daria, Altmann, Daniel M., Boyton, Rosemary J., Mullish, Benjamin H., Marchesi, Julian R., Bower, Mark

“…Sensitivity to immune checkpoint inhibitor (ICPI) therapy is governed by a complex interplay of tumor and host-related determinants. Epidemiological studies…”
Get full text

Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy by Pinato, David J., Murray, Sam M, Forner, Alejandro, Kaneko, Takahiro, Fessas, Petros, Toniutto, Pierluigi, Mínguez, Beatriz, Cacciato, Valentina, Avellini, Claudio, Diaz, Alba, Boyton, Rosemary J., Altmann, Daniel M., Goldin, Robert D, Akarca, Ayse U, Marafioti, Teresa, Mauri, Francesco A, Casagrande, Edoardo, Grillo, Federica, Giannini, Edoardo, Bhoori, Sherrie, Mazzaferro, Vincenzo

“…BackgroundModulation of adaptive immunity may underscore the efficacy of trans-arterial chemoembolization (TACE). We evaluated the influence of TACE on T-cell…”
Get full text

Serum biomarkers associated with SARS-CoV-2 severity by de Morais Batista, Fabiani, Puga, Marco Antonio Moreira, da Silva, Patricia Vieira, Oliveira, Roberto, dos Santos, Paulo Cesar Pereira, da Silva, Bruna Oliveira, Tatara, Mariana Bento, Tsuha, Daniel Henrique, dos Santos Pires, Maria Aparecida, Gonçalves, Crhistinne Cavalheiro Maymone, Pessoa e Silva, Rômulo, Ferreira, Nathália Tavares, de Barros Albuquerque, Amanda Pinheiro, da Silva Duarte, Giselle, Consolaro, Márcia Edilaine Lopes, Negrão, Fabio Juliano, Ferrari, Idalina Cristina, de Goes Cavalcanti, Luciano Pamplona, Trinta, Karen Soares, Ribeiro, Guilherme S., de Melo Rêgo, Moacyr Jesus Barreto, Boyton, Rosemary J., Siqueira, André Machado, Altmann, Daniel M., Croda, Julio

“…Immunity with SARS-CoV-2 infection during the acute phase is not sufficiently well understood to differentiate mild from severe cases and identify prognostic…”
Get full text

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection by Captur, Gabriella, Moon, James C., Topriceanu, Constantin-Cristian, Joy, George, Swadling, Leo, Hallqvist, Jenny, Doykov, Ivan, Patel, Nina, Spiewak, Justyna, Baldwin, Tomas, Hamblin, Matt, Menacho, Katia, Fontana, Marianna, Treibel, Thomas A., Manisty, Charlotte, O'Brien, Ben, Gibbons, Joseph M., Pade, Corrina, Brooks, Tim, Altmann, Daniel M., Boyton, Rosemary J., McKnight, Áine, Maini, Mala K., Noursadeghi, Mahdad, Mills, Kevin, Heywood, Wendy E.

“…The majority of those infected by ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not…”
Get full text

Consensus on the development of vaccines against naturally acquired melioidosis by Limmathurotsakul, Direk, Funnell, Simon G P, Torres, Alfredo G, Morici, Lisa A, Brett, Paul J, Dunachie, Susanna, Atkins, Timothy, Altmann, Daniel M, Bancroft, Gregory, Peacock, Sharon J

“…Several candidates for a vaccine against Burkholderia pseudomallei, the causal bacterium of melioidosis, have been developed, and a rational approach is now…”
Get full text

SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition by Altmann, Daniel M., Reynolds, Catherine J., Boyton, Rosemary J.

“…COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and…”
Get full text

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia by Gregorova, Michaela, Morse, Daniel, Brignoli, Tarcisio, Steventon, Joseph, Hamilton, Fergus, Albur, Mahableshwar, Arnold, David, Thomas, Matthew, Halliday, Alice, Baum, Holly, Rice, Christopher, Avison, Matthew B, Davidson, Andrew D, Santopaolo, Marianna, Oliver, Elizabeth, Goenka, Anu, Finn, Adam, Wooldridge, Linda, Amulic, Borko, Boyton, Rosemary J, Altmann, Daniel M, Butler, David K, McMurray, Claire, Stockton, Joanna, Nicholls, Sam, Cooper, Charles, Loman, Nicholas, Cox, Michael J, Rivino, Laura, Massey, Ruth C

“…Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by that acquired increasing levels of…”
Get full text

Hybrid Immunity Results in Enhanced and More Sustained Antibody Responses after the Second Sinovac-CoronaVac Dose in a Brazilian Cohort: DETECTCoV-19 Cohort by Salgado, Bárbara Batista, Barbosa, Aguyda Rayany Cavalcante, Arcanjo, Ana Ruth, de Castro, Daniel Barros, Ramos, Tatyana Costa Amorim, Naveca, Felipe, Altmann, Daniel M, Boyton, Rosemary J, Lalwani, Jaila Dias Borges, Lalwani, Pritesh

“…We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case-control study performed in CoronaVac-immunized…”
Get full text

KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells by Sim, Malcolm J. W., Stowell, Janet, Sergeant, Ruhena, Altmann, Daniel M., Long, Eric O., Boyton, Rosemary J.

“…Killer cell immunoglobulin‐like receptor/HLA class I (KIR/HLA‐I) combinations are associated with disease risk, implicating functional roles for NK cells…”
Get full text

Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection by Manisty, Charlotte, Treibel, Thomas Alexander, Jensen, Melanie, Semper, Amanda, Joy, George, Gupta, Rishi K, Cutino-Moguel, Teresa, Andiapen, Mervyn, Jones, Jessica, Taylor, Stephen, Otter, Ashley, Pade, Corrina, Gibbons, Joseph, Lee, Jason, Bacon, Joanna, Thomas, Steve, Moon, Chris, Jones, Meleri, Williams, Dylan, Lambourne, Jonathan, Fontana, Marianna, Altmann, Daniel M, Boyton, Rosemary, Maini, Mala, McKnight, Aine, Chain, Benjamin, Noursadeghi, Mahdad, Moon, James C

“…SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to…”
Get full text