Search Results - "Altenhofen, Delsi"

Neratinib protects pancreatic beta cells in diabetes by Ardestani, Amin, Li, Sijia, Annamalai, Karthika, Lupse, Blaz, Geravandi, Shirin, Dobrowolski, Aleksandra, Yu, Shan, Zhu, Siying, Baguley, Tyler D., Surakattula, Murali, Oetjen, Janina, Hauberg-Lotte, Lena, Herranz, Raquel, Awal, Sushil, Altenhofen, Delsi, Nguyen-Tran, Van, Joseph, Sean, Schultz, Peter G., Chatterjee, Arnab K., Rogers, Nikki, Tremblay, Matthew S., Shen, Weijun, Maedler, Kathrin

“…The loss of functional insulin-producing β-cells is a hallmark of diabetes. Mammalian sterile 20-like kinase 1 (MST1) is a key regulator of pancreatic β-cell…”
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Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development by Rehman, Sayeed ur, Schallschmidt, Tanja, Rasche, Axel, Knebel, Birgit, Stermann, Torben, Altenhofen, Delsi, Herwig, Ralf, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

“…Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell function. To…”
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E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice by Altenhofen, Delsi, Khuong, Jenny Minh-An, Kuhn, Tanja, Lebek, Sandra, Görigk, Sarah, Kaiser, Katharina, Binsch, Christian, Griess, Kerstin, Knebel, Birgit, Belgardt, Bengt-Frederik, Cames, Sandra, Eickelschulte, Samaneh, Stermann, Torben, Rasche, Axel, Herwig, Ralf, Weiss, Jürgen, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

“…Type 2 diabetes (T2D) represents a multifactorial metabolic disease with a strong genetic predisposition. Despite elaborate efforts in identifying the genetic…”
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Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle by Klymenko, Oleksiy, Brecklinghaus, Tim, Dille, Matthias, Springer, Christian, de Wendt, Christian, Altenhofen, Delsi, Binsch, Christian, Knebel, Birgit, Scheller, Jürgen, Hardt, Christopher, Herwig, Ralf, Chadt, Alexandra, Pfluger, Paul T., Al-Hasani, Hadi, Kabra, Dhiraj G.

“…Physical exercise training is associated with increased glucose uptake in skeletal muscle and improved glycemic control. HDAC5, a class IIa histone…”
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Fluconazole and amphotericin-B resistance are associated with increased catalase and superoxide dismutase activity in Candida albicans and Candida dubliniensis by Linares, Carlos Eduardo Blanco, Giacomelli, Sandro Rogério, Altenhofen, Delsi, Alves, Sydney Hartz, Morsch, Vera Maria, Schetinger, Maria Rosa Chitolina

“…Candida dubliniensis, a new species of Candida that has been recovered from several sites in healthy people, has been associated with recurrent episodes of…”
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Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes by Görigk, Sarah, Ouwens, D. Margriet, Kuhn, Tanja, Altenhofen, Delsi, Binsch, Christian, Damen, Mareike, Khuong, Jenny Minh-An, Kaiser, Katharina, Knebel, Birgit, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

“…Changes in intracellular CoA levels are known to contribute to the development of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D) in human…”
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Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene by Kuhn, Tanja, Kaiser, Katharina, Lebek, Sandra, Altenhofen, Delsi, Knebel, Birgit, Herwig, Ralf, Rasche, Axel, Pelligra, Angela, Görigk, Sarah, Khuong, Jenny Minh-An, Vogel, Heike, Schürmann, Annette, Blüher, Matthias, Chadt, Alexandra, Al-Hasani, Hadi

“…Abstract To nominate novel disease genes for obesity and type 2 diabetes (T2D), we recently generated two mouse backcross populations of the T2D-susceptible…”
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Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model by Bódis, Kálmán, Breuer, Saida, Crepzia‐Pevzner, Assja, Zaharia, Oana‐Patricia, Schön, Martin, Saatmann, Nina, Altenhofen, Delsi, Springer, Christian, Szendroedi, Julia, Wagner, Robert, Al‐Hasani, Hadi, Roden, Michael, Pesta, Dominik, Chadt, Alexandra

“…Aims Exercise training induces white adipose tissue (WAT) beiging and improves glucose homeostasis and mitochondrial function in rodents. This could be…”
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Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations by Schallschmidt, Tanja, Lebek, Sandra, Altenhofen, Delsi, Damen, Mareike, Schulte, Yvonne, Knebel, Birgit, Herwig, Ralf, Rasche, Axel, Stermann, Torben, Kamitz, Anne, Hallahan, Nicole, Jähnert, Markus, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

“…To identify novel disease genes for type 2 diabetes (T2D) we generated two backcross populations of obese and diabetes-susceptible New Zealand Obese (NZO/HI)…”
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A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes by Vogel, Heike, Kamitz, Anne, Hallahan, Nicole, Lebek, Sandra, Schallschmidt, Tanja, Jonas, Wenke, Jähnert, Markus, Gottmann, Pascal, Zellner, Lisa, Kanzleiter, Timo, Damen, Mareike, Altenhofen, Delsi, Burkhardt, Ralph, Renner, Simone, Dahlhoff, Maik, Wolf, Eckhard, Müller, Timo D, Blüher, Matthias, Joost, Hans-Georg, Chadt, Alexandra, Al-Hasani, Hadi, Schürmann, Annette

“…Abstract To explore the genetic determinants of obesity and Type 2 diabetes (T2D), the German Center for Diabetes Research (DZD) conducted crossbreedings of…”
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Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice by Stermann, Torben, Menzel, Franziska, Weidlich, Carmen, Jeruschke, Kay, Weiss, Jürgen, Altenhofen, Delsi, Benninghoff, Tim, Pujol, Anna, Bosch, Fatima, Rustenbeck, Ingo, Ouwens, D Margriet, Thoresen, G Hege, de Wendt, Christian, Lebek, Sandra, Schallschmidt, Tanja, Kragl, Martin, Lammert, Eckhard, Chadt, Alexandra, Al-Hasani, Hadi

“…The Rab guanosine triphosphatase-activating protein (RabGAP) TBC1D1 has been shown to be a key regulator of glucose and lipid metabolism in skeletal muscle…”
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Fern-9(11)-ene-2α,3β-diol Action on Insulin Secretion under Hyperglycemic Conditions by Castro, Allisson Jhonatan Gomes, Cazarolli, Luisa Helena, da Luz, Gabrielle, Altenhofen, Delsi, da Silva, Hemily Batista, de Carvalho, Francieli Kanumfre, Pizzolatti, Moacir Geraldo, Silva, Fátima Regina Mena Barreto

“…The objective of this study was to investigate the effect and the mechanism of action of fernenediol as an insulin secretagogue. Wistar rats were treated with…”
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Bis‐Pyrano Prenyl Isoflavone Improves Glucose Homeostasis by Inhibiting Dipeptidyl Peptidase‐4 in Hyperglycemic Rats by Altenhofen, Delsi, da Luz, Gabrielle, Frederico, Marisa Jádna Silva, Venzke, Dalila, Brich, Mayara, Vigil, Silvana, Fröde, Tania Silvia, Linares, Carlos Eduardo Blanco, Pizzolatti, Moacir Geraldo, Silva, Fátima Regina Mena Barreto

“…ABSTRACT Isoflavones widely distributed in plants prevent diabetes. This study investigated the in vivo and in vitro effect of…”
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Acute effect of 3β-hidroxihop-22(29)ene on insulin secretion is mediated by GLP-1, potassium and calcium channels for the glucose homeostasis by Castro, Allisson Jhonatan Gomes, Cazarolli, Luisa Helena, Carvalho, Francieli Kanumfre de, Luz, Gabrielle da, Altenhofen, Delsi, Santos, Adair Roberto Soares dos, Pizzolatti, Moacir Geraldo, Silva, Fátima Regina Mena Barreto

“…•3β-Hidroxihop-22(29)ene stimulates secretory activity of intestinal and β-cells.•Ionic channels and protein kinases mediate the action of triterpene for…”
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Incretinomimetic and Insulinomimetic Effect of (2E)-N′-(1′-Naphthyl)-3,4,5-Trimethoxybenzohydrazide for Glycemic Homeostasis by Silva Frederico, Marisa Jádna, Mascarello, Alessandra, Castro, Allisson Jhonatan Gomes, Da Luz, Gabrielle, Altenhofen, Delsi, Mendes, Camila Pires, Leal, Paulo Cesar, Yunes, Rosendo Augusto, Nunes, Ricardo José, Silva, Fátima Regina Mena Barreto

“…ABSTRACT To characterize the role and the mechanism of action of (2E)‐N′‐(1′‐naphthyl)‐3,4,5‐trimethoxybenzohydrazide (BZD) on incretin secretion, glucose…”
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