Search Results - "Altei, Wanessa"
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The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro
Published in International journal of molecular sciences (03-02-2022)“…Breast cancer is characterized by a hypoxic microenvironment inside the tumor mass, contributing to cell metastatic behavior. Hypoxia induces the expression of…”
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2
Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using 1H HR-MAS NMR spectroscopy
Published in Journal of pharmaceutical and biomedical analysis (30-11-2017)“…•Evaluated the effects of chemotherapy on profile metabolic of breast cancer cells using the NMR is proposed.•NMR spectra show differences on the metabolic…”
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3
Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles
Published in Cell communication and signaling (25-09-2020)“…Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors…”
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4
Effects of Doxorubicin, Cisplatin, and Tamoxifen on the Metabolic Profile of Human Breast Cancer MCF‑7 Cells As Determined by 1H High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance
Published in Biochemistry (Easton) (25-04-2017)“…Doxorubicin (Doxo), cisplatin (Cis), and tamoxifen (Tamo) are part of many chemotherapeutic regimens. However, there have been limited studies of the way…”
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5
Comparing extracellular vesicles and cell membranes as biocompatible coatings for gold nanorods: Implications for targeted theranostics
Published in European journal of pharmaceutics and biopharmaceutics (01-07-2022)“…[Display omitted] Extracellular vesicles (EVs) and cell membrane nanoghosts are excellent coatings for nanomaterials, providing enhanced delivery in the target…”
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6
Alternagin-C (ALT-C), a disintegrin-like protein, attenuates alpha2beta1 integrin and VEGF receptor 2 signaling resulting in angiogenesis inhibition
Published in Biochimie (01-07-2020)“…Angiogenesis, a crucial process in tumor progression, is mainly regulated by vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have…”
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7
Recombinant RGD-disintegrin DisBa-01 blocks integrin α v β 3 and impairs VEGF signaling in endothelial cells
Published in Cell communication and signaling (20-03-2019)“…Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies…”
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8
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
Published in European journal of medicinal chemistry (01-05-2013)“…Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were…”
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9
Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration
Published in Anti-cancer agents in medicinal chemistry (01-01-2021)“…Triple-negative BC is the most aggressive type of breast cancer and its lack of responsiveness to conventional therapies requires screening of new chemical…”
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10
Effects of Doxorubicin, Cisplatin, and Tamoxifen on the Metabolic Profile of Human Breast Cancer MCF-7 Cells As Determined by 1 H High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance
Published in Biochemistry (Easton) (25-04-2017)“…Doxorubicin (Doxo), cisplatin (Cis), and tamoxifen (Tamo) are part of many chemotherapeutic regimens. However, there have been limited studies of the way…”
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11
Characterization of metabolic profile of intact non-tumor and tumor breast cells by high-resolution magic angle spinning nuclear magnetic resonance spectroscopy
Published in Analytical biochemistry (01-11-2015)“…1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR–MAS NMR) spectroscopy was used to analyze the metabolic profile of an intact…”
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12
Metastasis inhibition in breast cancer by targeting cancer cell extravasation
Published in Breast cancer targets and therapy (01-01-2019)“…The spread of cells from primary tumors toward distant tissues and organs, also known as metastasis, is responsible for most cancer-associated deaths. The…”
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13
Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using 1 H HR-MAS NMR spectroscopy
Published in Journal of pharmaceutical and biomedical analysis (01-11-2017)“…Doxorubicin, cisplatin, and tamoxifen are part of many chemotherapeutic regimens. However, studies investigating the effect of chemotherapy on the metabolism…”
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14
Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activity
Published in Phytochemistry (Oxford) (01-11-2014)“…Jatrophidin I was isolated from the latex of Jatropha curcas L. Studies of molecular dynamic simulations based on 2D NMR data showed the behavior of the…”
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15
N-(1′-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia
Published in European journal of medicinal chemistry (26-05-2015)“…Tubulin-interacting agents, like vinca alkaloid and taxanes, play a fundamental role in cancer chemotherapy, making cellular microtubules (MT), one of the few…”
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16
Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells
Published in Cell communication and signaling (20-03-2019)“…Background Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix…”
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17
Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion
Published in International journal of molecular sciences (21-10-2022)“…Hypoxia, a condition of low oxygenation frequently found in triple-negative breast tumors (TNBC), promotes extracellular vesicle (EV) secretion and favors cell…”
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18
Processing of high resolution magic angle spinning spectra of breast cancer cells by the filter diagonalization method
Published in Analyst (London) (07-10-2012)“…Proton nuclear magnetic resonance ((1)H NMR) spectroscopy for detection of biochemical changes in biological samples is a successful technique. However, the…”
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19
Blockage of αvβ3 integrin in 3D culture of triple-negative breast cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal plasticity
Published in Biochemistry and biophysics reports (01-07-2024)“…Breast cancer is a relevant cause of mortality in women and its triple-negative subtype (TNBC) is usually associated with poor prognosis. During tumor…”
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20
EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence
Published in Heliyon (30-07-2024)“…Extracellular vesicles (EVs), ubiquitously released by blood cells, facilitate intercellular communication. In cancer, tumor-derived EVs profoundly affect the…”
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