Search Results - "Altcheh, Jaime"

Review of pharmacological options for the treatment of Chagas disease by Lascano, Fernanda, García Bournissen, Facundo, Altcheh, Jaime

“…Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both rural and urban areas. CD was first described over a century ago, but…”
Get full text

Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women by Carlier, Yves, Altcheh, Jaime, Angheben, Andrea, Freilij, Hector, Luquetti, Alejandro O, Schijman, Alejandro G, Segovia, Manuel, Wagner, Noemie, Albajar Vinas, Pedro

“…Some cCD cases can present nonspecific symptoms, if any, as seen in other intrauterine or perinatal infections (like Toxoplasma gondii, Treponema pallidum,…”
Get full text

Major benznidazole metabolites in patients treated for Chagas disease: Mass spectrometry-based identification, structural analysis and detoxification pathways by Pérez Montilla, Carlos A., Moroni, Samanta, Moscatelli, Guillermo, Rocco, Daniela M., González, Nicolas, Altcheh, Jaime M., Bournissen, Facundo García

“…Benznidazole is the drug of choice for the treatment of Chagas disease, but its metabolism in humans is unclear. Here, we identified and characterized the…”
Get full text

Prospective, historically controlled study to evaluate the efficacy and safety of a new paediatric formulation of nifurtimox in children aged 0 to 17 years with Chagas disease one year after treatment (CHICO) by Altcheh, Jaime, Castro, Luis, Dib, Juan C, Grossmann, Ulrike, Huang, Erya, Moscatelli, Guillermo, Pinto Rocha, Jimy José, Ramírez, Teresa Estela

“…Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited. We investigated the efficacy, safety and tolerability of…”
Get full text

Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients by Romer, Guadalupe, Bracco, Leonel A, Ricci, Alejandro D, Balouz, Virginia, Berná, Luisa, Villar, Juan C, Ramsey, Janine M, Nolan, Melissa S, Torrico, Faustino, Kesper, Norival, Altcheh, Jaime, Robello, Carlos, Buscaglia, Carlos A, Agüero, Fernán

“…Trypanosoma cruzi, the agent of Chagas disease, displays a highly structured population, with multiple strains that can be grouped into 6-7 evolutionary…”
Get full text

Prevention of congenital Chagas through treatment of girls and women of childbearing age by Moscatelli, Guillermo, Moroni, Samanta, García-Bournissen, Facundo, Ballering, Griselda, Bisio, Margarita, Freilij, Héctor, Altcheh, Jaime

“…It is currently unknown whether treatment of Chagas disease decreases the risk of congenital transmission from previously treated mothers to their infants. In…”
Get full text

Congenital syphilis in Argentina: Experience in a pediatric hospital by Garcia, Luciana Noemí, Destito Solján, Alejandra, Moroni, Samanta, Falk, Nicolas, Gonzalez, Nicolás, Moscatelli, Guillermo, Ballering, Griselda, García Bournissen, Facundo, Altcheh, Jaime M

“…In spite of being preventable, Congenital syphilis (CS) is still an important, and growing health problem worldwide. Fetal infection can be particularly…”
Get full text

The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas by Ricci, Alejandro D., Bracco, Leonel, Salas-Sarduy, Emir, Ramsey, Janine M., Nolan, Melissa S., Lynn, M. Katie, Altcheh, Jaime, Ballering, Griselda E., Torrico, Faustino, Kesper, Norival, Villar, Juan C., Marcipar, Iván S., Marco, Jorge D., Agüero, Fernán

“…During an infection the immune system produces pathogen-specific antibodies. These antibody repertoires become specific to the history of infections and…”
Get full text

Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study by Moscatelli, Guillermo, Moroni, Samanta, Ramírez, Juan Carlos, Warszatska, Belén, Fernanda, Lascano, González, Nicolás, Rabinovich, Andrés, Altcheh, Jaime

“…In regions with controlled vector transmission of T. cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ)…”
Get full text

An α-Gal antigenic surrogate as a biomarker of treatment evaluation in Trypanosoma cruzi-infected children. A retrospective cohort study by Abal, Manuel, Balouz, Virginia, Lopez, Rosana, Giorgi, M Eugenia, Marino, Carla, Cruz, Cintia V, Altcheh, Jaime, Buscaglia, Carlos A

“…Proper evaluation of therapeutic responses in Chagas disease is hampered by the prolonged persistence of antibodies to Trypanosoma cruzi measured by…”
Get full text

Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study by González, Nicolás Leonel, Moscatelli, Guillermo, Moroni, Samanta, Ballering, Griselda, Jurado, Laura, Falk, Nicolás, Bochoeyer, Andrés, Goldsman, Alejandro, Grippo, María, Freilij, Héctor, Garcia Bournissen, Facundo, Chatelain, Eric, Altcheh, Jaime

“…Parasite persistence after acute infection with Trypanosoma cruzi is an important factor in the development of Chagas disease (CD) cardiomyopathy. Few studies…”
Get full text

Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults by Altcheh, Jaime, Moscatelli, Guillermo, Mastrantonio, Guido, Moroni, Samanta, Giglio, Norberto, Marson, Maria Elena, Ballering, Griselda, Bisio, Margarita, Koren, Gideon, García-Bournissen, Facundo

“…Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no…”
Get full text

Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients by Duffy, Tomas, Bisio, Margarita, Altcheh, Jaime, Burgos, Juan Miguel, Diez, Mirta, Levin, Mariano Jorge, Favaloro, Roberto Rene, Freilij, Hector, Schijman, Alejandro Gabriel

“…This report describes a real-time PCR (Q-PCR) strategy to quantify Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease patients…”
Get full text

Longitudinal follow up of serological response in children treated for Chagas disease by Moscatelli, Guillermo, Moroni, Samanta, García Bournissen, Facundo, González, Nicolás, Ballering, Griselda, Schijman, Alejandro, Corral, Ricardo, Bisio, Margarita, Freilij, Héctor, Altcheh, Jaime

“…Evaluation of therapeutic response in chronic Chagas disease is a major challenge, due to prolonged persistence of Trypanosoma cruzi-specific antibodies, lack…”
Get full text

Secretome analysis of Trypanosoma cruzi by proteomics studies by Brossas, Jean-Yves, Gulin, Julián Ernesto Nicolás, Bisio, Margarita Maria Catalina, Chapelle, Manuel, Marinach-Patrice, Carine, Bordessoules, Mallaury, Palazon Ruiz, George, Vion, Jeremy, Paris, Luc, Altcheh, Jaime, Mazier, Dominique

“…Chagas disease is a debilitating often fatal disease resulting from infection by the protozoan parasite Trypanosoma cruzi. Chagas disease is endemic in 21…”
Get full text

ELISA F29 -A therapeutic efficacy biomarker in Chagas disease: Evaluation in pediatric patients treated with nifurtimox and followed for 4 years post-treatment by Rivero, Rocio, Esteva, Mónica Inés, Huang, Erya, Colmegna, Leylen, Altcheh, Jaime, Grossmann, Ulrike, Ruiz, Andrés Mariano

“…Measurement of the success of antitrypanosomal treatment for Chagas disease is difficult, particularly in the chronic phase of the disease, because…”
Get full text

Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes by Mucci, Juan, Carmona, Santiago J, Volcovich, Romina, Altcheh, Jaime, Bracamonte, Estefanía, Marco, Jorge D, Nielsen, Morten, Buscaglia, Carlos A, Agüero, Fernán

“…Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs…”
Get full text

Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation by Altcheh, Jaime, Moscatelli, Guillermo, Caruso, Martin, Moroni, Samanta, Bisio, Margarita, Miranda, Maria Rosa, Monla, Celia, Vaina, Maria, Valdez, Maria, Moran, Lucrecia, Ramirez, Teresa, Patiño, Oscar Ledesma, Riarte, Adelina, Gonzalez, Nicolas, Fernandes, Jayme, Alves, Fabiana, Ribeiro, Isabela, Garcia-Bournissen, Facundo

“…There is a major need for information on pharmacokinetics (PK) of benznidazole (BNZ) in children with Chagas disease (CD). We conducted a multicentre…”
Get full text

Negligible exposure to nifurtimox through breast milk during maternal treatment for Chagas Disease by Moroni, Samanta, Marson, Maria Elena, Moscatelli, Guillermo, Mastrantonio, Guido, Bisio, Margarita, Gonzalez, Nicolas, Ballering, Griselda, Altcheh, Jaime, García-Bournissen, Facundo

“…Treatment with nifurtimox (NF) for Chagas disease is discouraged during breast-feeding because no information on NF transfer into breast milk is available. NF…”
Get full text

Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact by Garcia, Luciana N, Morando, Nicolás, Otero, Adrián V, Moroni, Samanta, Moscatelli, Guillermo F, Gonzalez, Nicolás, D Slojan, Alejandra, Lascano, Fernanda, Ballering, Griselda, Pando, Maria A, Altcheh, Jaime M

“…There are scarce data of subsp. (TPA) characterization in children with syphilis. Nonsexually acquired transmission (NSAT) of TPA is possible in infants…”
Get full text