Changes of tumor necrosis factor-α, interleukin-10, and tartrate-resistant acid phosphatase5b in the crevicular fluid in relation to orthodontic movement

The aim of this study was to determine gingival crevicular fluid (GCF) expressions of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and tartrate-resistant acid phosphatase (TRAP) 5b in the mechanism of orthodontic tooth movement. Nine adolescents requiring canine distalization participate...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of inflammation Vol. 13; no. 1; pp. 3 - 13
Main Authors:	Karaduman, B, Uraz, A, Altan, GN, Baloş Tuncer, B, Alkan, Ö, Gönen, S, Pehlivan, S, Çetiner, D
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2015 SAGE PUBLICATIONS, INC SAGE Publishing
Subjects:	Cytokines Necrosis Orthodontics Teeth Tumor necrosis factor-TNF tumor necrosis factor-alpha gingival crevicular fluid bone remodeling tartrateresistant acid phosphatase tooth movement interleukin-10
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The aim of this study was to determine gingival crevicular fluid (GCF) expressions of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and tartrate-resistant acid phosphatase (TRAP) 5b in the mechanism of orthodontic tooth movement. Nine adolescents requiring canine distalization participated in the study. A canine undergoing distal movement served as the test tooth, and the contra-lateral canine served as the control. The clinical parameters were recorded and GCF samples were collected from the mesial and distal gingival crevices of teeth at baseline, 1 h, 24 h, 7 days, and 28 days following force application. GCF samples were analyzed using ELISA. The data were analyzed using three-way repeated measures analysis of variance. TNF-α and TRAP5b levels in distal and mesial sites of the test teeth were significantly higher than that at both sites of the controls. When compared with baseline values, increase was prominent at 1 h and 24 h. The IL-10 concentration decreased during experimental period at both sites of the control and test teeth. The results demonstrated that orthodontic forces evoke changes in the levels of TNF-α, IL-10, and TRAP5b during the initial stages of force application. The changes in local host response in periodontal tissues may be one of the triggers in regulating alveolar bone resorption during orthodontic tooth movement.
ISSN:	2058-7392 1721-727X 2058-7392
DOI:	10.1177/1721727X15573917