Search Results - "Altamimi, Abdulmalik Saleh Alfawaz"
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Cationic Solid Lipid Nanoparticles of Resveratrol for Hepatocellular Carcinoma Treatment: Systematic Optimization, in vitro Characterization and Preclinical Investigation
Published in International journal of nanomedicine (01-01-2020)“…The present study focuses on the development and evaluation of the resveratrol (RV)-loaded cationic solid lipid nanoparticles (RV-c-SLNs) for the management of…”
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Enhanced Brain Delivery via Intranasal Administration of Carbamazepine Loaded Solid Lipid Nanoparticles: Optimization, Pharmacokinetic Analysis, In-vitro , and In-vivo Drug Release Study
Published in Current drug delivery (01-01-2023)“…Carbamazepine (Cbz) is the first-line drug for epileptic seizures but exhibits fluctuation at the plasma level and side effects after oral administration.To…”
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Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation
Published in Arabian journal of chemistry (01-12-2022)“…Gefitinib (GFB) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC), but it also…”
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Galangin as an inflammatory response modulator: An updated overview and therapeutic potential
Published in Chemico-biological interactions (01-06-2023)“…Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an…”
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Neuropharmacological effect of risperidone: From chemistry to medicine
Published in Chemico-biological interactions (05-01-2023)“…As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage for treating behavioural and psychological signs and symptoms of…”
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Kaempferol: Paving the path for advanced treatments in aging-related diseases
Published in Experimental gerontology (01-04-2024)“…Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found…”
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Chiral-engineered supraparticles: Emerging tools for drug delivery
Published in Drug discovery today (01-01-2023)“…•Molecular chirality recognized in pharmacokinetics and pharmacodynamics.•Supramolecular polymers (SPs) are excellent systems in biological system…”
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An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy
Published in Chemico-biological interactions (01-10-2022)“…Epithelial growth factor receptor (EGFR), a transmembrane receptor on the cell surface, carries extracellular messages into the cell and alters the activity of…”
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Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Management of Rheumatoid Arthritis
Published in Journal of medicinal chemistry (14-06-2018)“…Herein we report the design as well as the synthesis of a new series of dual hybrid compounds consisting of the therapeutically used…”
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A narrative review on the biology of piezo1 with platelet-rich plasma in cardiac cell regeneration
Published in Chemico-biological interactions (25-08-2022)“…Cardiomyocyte regeneration following cardiac damage is challenging to study because of the inflammatory process, the multiplication of cells in the stroma, and…”
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Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora
Published in Chemico-biological interactions (01-05-2022)“…Coronavirus disease (COVID-19), a coronavirus-induced illness attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, is…”
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Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase
Published in Molecules (Basel, Switzerland) (20-04-2021)“…Ten benzoxazole clubbed 2-pyrrolidinones ( - ) as human monoacylglycerol lipase inhibitors were designed on the criteria fulfilling the structural requirements…”
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Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review
Published in EXCLI journal (01-01-2024)“…This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique…”
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Harnessing chitosan-adorned liposomes for enhanced drug delivery in cancer
Published in Journal of drug delivery science and technology (01-08-2023)“…Cancer is a progressive disease that is caused by a combination of factors, including one's genetics, environment, and lifestyle choices. The pillars of cancer…”
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Chitosan-based nano drug delivery system for lung cancer
Published in Journal of drug delivery science and technology (01-03-2023)“…Lung cancer is a broad term that encompasses several subtypes of the leading cause of cancer-related mortality. Despite substantial gains in studying pulmonary…”
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EGF‐functionalized lipid–polymer hybrid nanoparticles of 5‐fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma
Published in Biotechnology and applied biochemistry (01-10-2022)“…The present research work describes development of dual drug‐loaded lipid–polymer hybrid nanoparticles (LPHNPs) of anticancer therapeutics for the management…”
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Synthesis, Anticancer Activity, and In Silico Studies of 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine Analogs
Published in Molecules (Basel, Switzerland) (05-10-2023)“…In the current study, we described the synthesis of ten new 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine analogs (4a–j), as well as their…”
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Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies
Published in Molecules (Basel, Switzerland) (16-08-2023)“…We report herein the synthesis, docking studies and biological evaluation of a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues…”
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Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review
Published in Current pharmaceutical biotechnology (01-01-2024)“…Erectile Dysfunction (ED) is a prevalent sexual health condition affecting a significant portion of the male population worldwide. The conventional therapeutic…”
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Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction
Published in Molecules (Basel, Switzerland) (29-11-2020)“…Sepsis aggregates undesirable immune response causing depression of ventricular myocardium and diastolic dysfunction. This present study examined the effect of…”
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