Search Results - "Altabef, Abigail"

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors by Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin

“…The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We…”
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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR by QINGSONG LIU, CHUNXIAO XU, ERCAN, Dalia, NIEPEL, Mario, THOREEN, Carson C, KANG, Seong A, PATRICELLI, Matthew P, YUCHUAN WANG, TUPPER, Tanya, ALTABEF, Abigail, KAWAMURA, Hidemasa, HELD, Kathryn D, KIRUBAKARAN, Sivapriya, CHOU, Danny M, ELLEDGE, Stephen J, JANNE, Pasi A, WONG, Kwok-Kin, SABATINI, David M, GRAY, Nathanael S, XIN ZHANG, HUR, Wooyoung, YAN LIU, KWIATKOWSKI, Nicholas P, JINHUA WANG, WESTOVER, Kenneth D, PENG GAO

“…mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the…”
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Co-Clinical Trials Demonstrate Superiority of Crizotinib to Chemotherapy in ALK-Rearranged Non-Small Cell Lung Cancer and Predict Strategies to Overcome Resistance by ZHAO CHEN, AKBAY, Esra, REIBEL, Jacob B, JANNE, Pasi A, SHARPLESS, Norman E, ENGELMAN, Jeffrey A, SHAPIRO, Geoffrey I, KUNG, Andrew L, WONG, Kwok-Kin, MIKSE, Oliver, TUPPER, Tanya, CHENG, Katherine, YUCHUAN WANG, XIAOHONG TAN, ALTABEF, Abigail, WOO, Sue-Ann, LIANG CHEN

“…To extend the results of a phase III trial in patients with non-small cell lung cancer with adenocarcinomas harboring EML4-ALK fusion. We conducted a…”
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Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC by TCHAICHA, Jeremy H, AKBAY, Esra A, HAMMERMAN, Peter S, WONG, Kwok-Kin, ALTABEF, Abigail, MIKSE, Oliver R, KIKUCHI, Eiki, RHEE, Kevin, LIAO, Rachel G, BRONSON, Roderick T, SHOLL, Lynette M, MEYERSON, Matthew

“…Somatic mutations in FGFR2 are present in 4% to 5% of patients diagnosed with non-small cell lung cancer (NSCLC). Amplification and mutations in FGFR genes…”
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Abstract B290: Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors by Akbay, Esra A., Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy, Christensen, Camilla, Shimamura, Takeshi, Sholl, Lynette, Rodig, Scott, Freeman, Gordon, Hammerman, Peter, Dranoff, Glenn, Wong, Kwok-Kin

“…Abstract The recent clinical success of therapeutic blockade of the immune checkpoint Programmed Death (PD)-1 in advanced lung cancer patients suggests that…”
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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment by Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin

“…STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many…”
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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

“…Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification of effective pharmacological strategies to target SCLC…”
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Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression by Xu, Chunxiao, Fillmore, Christine M., Koyama, Shohei, Wu, Hongbo, Zhao, Yanqiu, Chen, Zhao, Herter-Sprie, Grit S., Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Reibel, Jacob B., Walton, Zandra, Ji, Hongbin, Watanabe, Hideo, Jänne, Pasi A., Castrillon, Diego H., Rustgi, Anil K., Bass, Adam J., Freeman, Gordon J., Padera, Robert F., Dranoff, Glenn, Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin

“…Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten…”
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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response by Chen, Zhao, Cheng, Katherine, Walton, Zandra, Wang, Yuchuan, Ebi, Hiromichi, Shimamura, Takeshi, Liu, Yan, Tupper, Tanya, Ouyang, Jing, Li, Jie, Gao, Peng, Woo, Michele S., Xu, Chunxiao, Yanagita, Masahiko, Altabef, Abigail, Wang, Shumei, Lee, Charles, Nakada, Yuji, Peña, Christopher G., Sun, Yanping, Franchetti, Yoko, Yao, Catherine, Saur, Amy, Cameron, Michael D., Nishino, Mizuki, Hayes, D. Neil, Wilkerson, Matthew D., Roberts, Patrick J., Lee, Carrie B., Bardeesy, Nabeel, Butaney, Mohit, Chirieac, Lucian R., Costa, Daniel B., Jackman, David, Sharpless, Norman E., Castrillon, Diego H., Demetri, George D., Jänne, Pasi A., Pandolfi, Pier Paolo, Cantley, Lewis C., Kung, Andrew L., Engelman, Jeffrey A., Wong, Kwok-Kin

“…In parallel with an ongoing human clinical trial, genetically engineered mouse models of lung cancer with different genetic alterations are treated with…”
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CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer by Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.

“…The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted…”
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Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer by Liu, Yan, Marks, Kevin, Cowley, Glenn S, Carretero, Julian, Liu, Qingsong, Nieland, Thomas J F, Xu, Chunxiao, Cohoon, Travis J, Gao, Peng, Zhang, Yong, Chen, Zhao, Altabef, Abigail B, Tchaicha, Jeremy H, Wang, Xiaoxu, Choe, Sung, Driggers, Edward M, Zhang, Jianming, Bailey, Sean T, Sharpless, Norman E, Hayes, D Neil, Patel, Nirali M, Janne, Pasi A, Bardeesy, Nabeel, Engelman, Jeffrey A, Manning, Brendan D, Shaw, Reuben J, Asara, John M, Scully, Ralph, Kimmelman, Alec, Byers, Lauren A, Gibbons, Don L, Wistuba, Ignacio I, Heymach, John V, Kwiatkowski, David J, Kim, William Y, Kung, Andrew L, Gray, Nathanael S, Root, David E, Cantley, Lewis C, Wong, Kwok-Kin

“…The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung…”
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Abstract PR05: Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells by Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.

“…Abstract The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has…”
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Abstract LB-125: Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma by Chipumuro, Edmond, Marco, Eugenio, Zhang, Tinghu, Christensen, Camilla, Kwiatkowski, Nicholas, Sharma, Bandana, Hatheway, Clark, Altabef, Abigail, Abraham, Brian J., Wong, Kwok-Kin, Yuan, Guo-Cheng, Young, Richard A., Gray, Nathanael S., George, Rani E.

“…Abstract Oncogenic MYC family transcription factors act as universal amplifiers of the existing gene expression program in many cancer cells, thus reducing…”
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Abstract 4851: Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC by Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Mikse, Oliver R., Kikuchi, Eiki, Rhee, Kevin, Liao, Rachel, Bronson, Roderick T., Sholl, Lynette M., Meyerson, Matthew, Hammerman, Peter S., Wong, Kwok-Kin

“…Abstract Somatic mutations in Fibroblast Growth Factor Receptor 2 (FGFR2) have been found in 4-5% of patients diagnosed with non-small cell lung cancer…”
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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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