Search Results - "Alt, Silke"

Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin by Alt, Silke, Wilkinson, Barrie

“…We report the identification of the biosynthetic gene cluster for the unusual antibiotic anthracimycin (atc) from the marine derived producer strain…”
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Towards the sustainable discovery and development of new antibiotics by Miethke, Marcus, Pieroni, Marco, Weber, Tilmann, Brönstrup, Mark, Hammann, Peter, Halby, Ludovic, Arimondo, Paola B., Glaser, Philippe, Aigle, Bertrand, Bode, Helge B., Moreira, Rui, Li, Yanyan, Luzhetskyy, Andriy, Medema, Marnix H., Pernodet, Jean-Luc, Stadler, Marc, Tormo, José Rubén, Genilloud, Olga, Truman, Andrew W., Weissman, Kira J., Takano, Eriko, Sabatini, Stefano, Stegmann, Evi, Brötz-Oesterhelt, Heike, Wohlleben, Wolfgang, Seemann, Myriam, Empting, Martin, Hirsch, Anna K. H., Loretz, Brigitta, Lehr, Claus-Michael, Titz, Alexander, Herrmann, Jennifer, Jaeger, Timo, Alt, Silke, Hesterkamp, Thomas, Winterhalter, Mathias, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Graz, Heather, Graz, Michael, Lindvall, Mika, Ramurthy, Savithri, Karlén, Anders, van Dongen, Maarten, Petkovic, Hrvoje, Keller, Andreas, Peyrane, Frédéric, Donadio, Stefano, Fraisse, Laurent, Piddock, Laura J. V., Gilbert, Ian H., Moser, Heinz E., Müller, Rolf

“…An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens…”
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Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products by Gomez-Escribano, Juan Pablo, Alt, Silke, Bibb, Mervyn J

“…Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new…”
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INCATE: a partnership to boost the antibiotic pipeline by Alt, Silke, Haggstrom, Douglas, Kessmann, Helmut, Kloss, Florian, Schneider, Christian Elias, Jäger, Timo, Schwede, Torsten, Brakhage, Axel, Dehio, Christoph

“…INCATE, the INCubator for Antibacterial Therapies in Europe, aims to boost the antibiotic pipeline by accelerating the translation of academic innovation into…”
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters by Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.

“…Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an…”
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Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C by Booth, Thomas J, Alt, Silke, Capon, Robert J, Wilkinson, Barrie

“…A growing number of natural products appear to arise from biosynthetic pathways that involve pericyclic reactions. We show here that for the heronamides this…”
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Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A by Edwards, Jennifer L, Balthazar, Jacqueline T, Esposito, Danillo L A, Ayala, Julio C, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Alt, Silke, Hesterkamp, Thomas, Grosse, Miriam, Stadler, Marc, Golparian, Daniel, Unemo, Magnus, Read, Timothy D, Shafer, William M

“…Gonorrhea remains a major global public health problem because of the high incidence of infection (estimated 82 million cases in 2020) and the emergence and…”
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In Vitro-In Vivo Relationship in Mini-Scale-Enabling Formulations of Corallopyronin A by Becker, Tim, Krome, Anna K, Vahdati, Sahel, Schiefer, Andrea, Pfarr, Kenneth, Ehrens, Alexandra, Aden, Tilman, Grosse, Miriam, Jansen, Rolf, Alt, Silke, Hesterkamp, Thomas, Stadler, Marc, Hübner, Marc P, Kehraus, Stefan, König, Gabriele M, Hoerauf, Achim, Wagner, Karl G

“…In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are…”
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A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete by Tocchetti, Arianna, Bordoni, Roberta, Gallo, Giuseppe, Petiti, Luca, Corti, Giorgio, Alt, Silke, Cruz, Joao C S, Salzano, Anna Maria, Scaloni, Andrea, Puglia, Anna Maria, De Bellis, Gianluca, Peano, Clelia, Donadio, Stefano, Sosio, Margherita

“…We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria…”
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Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry by Alt, Silke, Bernasconi, Alice, Sosio, Margherita, Brunati, Cristina, Donadio, Stefano, Maffioli, Sonia I

“…Glycopeptide antibiotics are used to treat severe multidrug resistant infections caused by Gram-positive bacteria. Dalbavancin is a second generation…”
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Capturing Linear Intermediates and C-Terminal Variants during Maturation of the Thiopeptide GE2270 by Tocchetti, Arianna, Maffioli, Sonia, Iorio, Marianna, Alt, Silke, Mazzei, Emma, Brunati, Cristina, Sosio, Margherita, Donadio, Stefano

“…Thiopeptides are ribosomally synthesized, posttranslationally modified peptides with potent activity against Gram-positives. However, only GE2270 has yielded…”
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Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics by Alt, Silke, Mitchenall, Lesley A., Maxwell, Anthony, Heide, Lutz

“…Objectives Aminocoumarin antibiotics are potent inhibitors of bacterial DNA gyrase. We investigated the inhibitory and antibacterial activity of naturally…”
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Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β‑Lactone Antibiotic by Scott, Thomas A, Batey, Sibyl F. D, Wiencek, Patrick, Chandra, Govind, Alt, Silke, Francklyn, Christopher S, Wilkinson, Barrie

“…To meet the ever-growing demands of antibiotic discovery, new chemical matter and antibiotic targets are urgently needed. Many potent natural product…”
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Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes by Ehrens, Alexandra, Schiefer, Andrea, Krome, Anna K., Becker, Tim, Rox, Katharina, Neufeld, Helene, Aden, Tilman, Wagner, Karl G., Müller, Rolf, Grosse, Miriam, Stadler, Marc, König, Gabriele M., Kehraus, Stefan, Alt, Silke, Hesterkamp, Thomas, Hübner, Marc Peter, Pfarr, Kenneth, Hoerauf, Achim

“…Corallopyronin A (CorA), a natural product antibiotic of Corallococcus coralloides , inhibits the bacterial DNA-dependent RNA polymerase. It is active against…”
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The catechol moiety of obafluorin is essential for antibacterial activity by Batey, Sibyl F. D, Davie, Melissa J, Hems, Edward S, Liston, Jonathon D, Scott, Thomas A, Alt, Silke, Francklyn, Christopher S, Wilkinson, Barrie

“…Obafluorin is a Pseudomonas fluorescens antibacterial natural product that inhibits threonyl-tRNA synthetase (ThrRS). It acts as a broad-spectrum antibiotic…”
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Towards the sustainable discovery and development of new antibiotics by Miethke, Marcus, Pieroni, Marco, Weber, Tilmann, Brönstrup, Mark, Hammann, Peter, Halby, Ludovic, Arimondo, Paola B, Glaser, Philippe, Aigle, Bertrand, Bode, Helge B, Moreira, Rui, Li, Yanyan, Luzhetskyy, Andriy, Medema, Marnix H, Pernodet, Jean-Luc, Stadler, Marc, Tormo, José Rubén, Genilloud, Olga, Truman, Andrew W, Weissman, Kira J, Takano, Eriko, Sabatini, Stefano, Stegmann, Evi, Brötz-Oesterhelt, Heike, Wohlleben, Wolfgang, Seemann, Myriam, Empting, Martin, Hirsch, Anna K H, Loretz, Brigitta, Lehr, Claus-Michael, Titz, Alexander, Herrmann, Jennifer, Jaeger, Timo, Alt, Silke, Hesterkamp, Thomas, Winterhalter, Mathias, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Graz, Heather, Graz, Michael, Lindvall, Mika, Ramurthy, Savithri, Karlén, Anders, van Dongen, Maarten, Petkovic, Hrvoje, Keller, Andreas, Peyrane, Frédéric, Donadio, Stefano, Fraisse, Laurent, Piddock, Laura J V, Gilbert, Ian H, Moser, Heinz E, Müller, Rolf

“…An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens…”
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Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety by Anderle, Christine, Alt, Silke, Gulder, Tanja, Bringmann, Gerhard, Kammerer, Bernd, Gust, Bertolt, Heide, Lutz

“…Clorobiocin is an aminocoumarin antibiotic containing a 5-methylpyrrolyl-2-carboxyl moiety, attached by an ester bond to a deoxysugar. This pyrrolyl moiety is…”
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A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete: e0133705 by Tocchetti, Arianna, Bordoni, Roberta, Gallo, Giuseppe, Petiti, Luca, Corti, Giorgio, Alt, Silke, Cruz, Joao CS, Salzano, Anna Maria, Scaloni, Andrea, Puglia, Anna Maria

“…We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria…”
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An Artificial Pathway to 3,4-Dihydroxybenzoic Acid Allows Generation of New Aminocoumarin Antibiotic Recognized by Catechol Transporters of E. coli by Alt, Silke, Burkard, Nadja, Kulik, Andreas, Grond, Stephanie, Heide, Lutz

“…An artificial operon was synthesized, consisting of the genes for chorismate pyruvate-lyase of E. coli and for 4-hydroxybenzoate 3-hydroxylase of…”
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