Search Results - "Alsup, Tyler A"

Bacterial terpenome by Rudolf, Jeffrey D, Alsup, Tyler A, Xu, Baofu, Li, Zining

“…Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most structurally diverse family of natural products. Found in all domains of…”
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The Natural Products Atlas 2.0: a database of microbially-derived natural products by van Santen, Jeffrey A, Poynton, Ella F, Iskakova, Dasha, McMann, Emily, Alsup, Tyler A, Clark, Trevor N, Fergusson, Claire H, Fewer, David P, Hughes, Alison H, McCadden, Caitlin A, Parra, Jonathan, Soldatou, Sylvia, Rudolf, Jeffrey D, Janssen, Elisabeth M-L, Duncan, Katherine R, Linington, Roger G

“…Abstract Within the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest…”
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Characterization of UbiA terpene synthases with a precursor overproduction system in Escherichia coli by Alsup, Tyler A, Opoku, Melvin Osei, Rudolf, Jeffrey D

“…Expression and purification of membrane-bound proteins remains a challenge and limits enzymology efforts, contributing to a substantial knowledge gap in the…”
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Cryptic Isomerization in Diterpene Biosynthesis and the Restoration of an Evolutionarily Defunct P450 by Li, Zining, Xu, Baofu, Alsup, Tyler A., Wei, Xiuting, Ning, Wenbo, Icenhour, Daniel G., Ehrenberger, Michelle A., Ghiviriga, Ion, Giang, Bao-Doan, Rudolf, Jeffrey D.

“…Biosynthetic modifications of the 6/10-bicyclic hydrocarbon skeletons of the eunicellane family of diterpenoids are unknown. We explored the biosynthesis of a…”
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Bacterial diterpene synthases prenylate small molecules by Xu, Baofu, Li, Zining, Alsup, Tyler A, Ehrenberger, Michelle A, Rudolf, Jeffrey D

“…The biosynthesis of terpenoid natural products begins with a carbocation-based cyclization or prenylation reaction. While these reactions are mechanistically…”
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Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization by Alsup, Tyler A, Li, Zining, McCadden, Caitlin A, Jagels, Annika, Łomowska-Keehner, Diana P, Marshall, Erin M, Dong, Liao-Bin, Loesgen, Sandra, Rudolf, Jeffrey D

“…The chemical logic associated with assembly of many bacterial terpenoids remains poorly understood. We focused our efforts on the early-stage biosynthesis of…”
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