Search Results - "Alsughayyir, Jawaher"

Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase by Alfhili, Mohammad A., Alsughayyir, Jawaher

“…Ample evidence indicates that bufalin (BFN), a cardiotonic steroid in Bufo toad toxin, possesses a potent anticancer activity mainly by stimulating apoptosis…”
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Stimulation of Hemolysis and Eryptosis by α-Mangostin through Rac1 GTPase and Oxidative Injury in Human Red Blood Cells by Alghareeb, Sumiah A, Alsughayyir, Jawaher, Alfhili, Mohammad A

“…Background: Chemotherapy-related anemia is prevalent in up to 75% of patients, which may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a…”
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Rosmarinic Acid Elicits Calcium-Dependent and Sucrose-Sensitive Eryptosis and Hemolysis through p38 MAPK, CK1α, and PKC by Alghareeb, Sumiah A, Alfhili, Mohammad A, Alsughayyir, Jawaher

“…Rosmarinic acid (RA) possesses promising anticancer potential, but further development of chemotherapeutic agents is hindered by their toxicity to off-target…”
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Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation by Alsughayyir, Jawaher, Pettigrew, Gavin J, Motallebzadeh, Reza

“…Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs…”
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Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis by Alfhili, Mohammad A., Basudan, Ahmed M., Aljaser, Feda S., Dera, Ayed, Alsughayyir, Jawaher

“…Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is a cytokine that initiates apoptosis upon binding to death receptor 5 (DR5) on cancer cells…”
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Eriocitrin Disrupts Erythrocyte Membrane Asymmetry through Oxidative Stress and Calcium Signaling and the Activation of Casein Kinase 1α and Rac1 GTPase by Alghareeb, Sumiah A, Alsughayyir, Jawaher, Alfhili, Mohammad A

“…Hemolysis and eryptosis result in the premature elimination of circulating erythrocytes and thus contribute to chemotherapy-related anemia, which is extremely…”
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Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes by Akiel, Maaged, Alsughayyir, Jawaher, Basudan, Ahmed M., Alamri, Hassan S., Dera, Ayed, Barhoumi, Tlili, Subayyil, Abdullah M. Al, Basmaeil, Yasser S., Aldakheel, Fahad M., Alakeel, Raid, Ghneim, Hazem K., Al-Sheikh, Yazeed A., Alraey, Yasser, Asiri, Saeed, Alfhili, Mohammad A.

“…The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell…”
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Stimulation of Calcium/NOS/CK1α Signaling by Cedrol Triggers Eryptosis and Hemolysis in Red Blood Cells by Alajeyan, Iman A, Alsughayyir, Jawaher, Alfhili, Mohammad A

“…Cedrol (CRL) is a sesquiterpene alcohol present in the essential oils of coniferous trees including and genera. CRL has shown potent anticancer activity by…”
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Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling by Alfhili, Mohammad A, Alamri, Hassan S, Alsughayyir, Jawaher, Basudan, Ahmed M

“…Nickel (Ni) is an abundant environmental hazard and an occupational pollutant. Exposure to Ni compounds is prevalent in electroplating workers and in the…”
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Stimulation of Hemolysis and Eryptosis by β-Caryophyllene Oxide by Alghareeb, Sumiah A, Alfhili, Mohammad A, Alsughayyir, Jawaher

“…Eryptosis stimulated by anticancer drugs can lead to anemia in patients. β-caryophyllene oxide (CPO) is an anticancer sesquiterpene present in various plants;…”
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Association of Platelet-Monocyte Ratio with Dyslipidemia in Saudi Arabia: A Large, Population-Based Study by Alfhili, Mohammad A, Alotaibi, Ghada A, Alfaifi, Mohammed, Almoghrabi, Yousef, Alsughayyir, Jawaher

“…Background: Abnormal lipid metabolism predisposes to cardiovascular disease. However, dyslipidemia is often asymptomatic leading to its underdiagnosis…”
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T-Cell Subsets and Interleukin-10 Levels Are Predictors of Severity and Mortality in COVID-19: A Systematic Review and Meta-Analysis by Alshammary, Amal F, Alsughayyir, Jawaher M, Alharbi, Khalid K, Al-Sulaiman, Abdulrahman M, Alshammary, Haifa F, Alshammary, Heba F

“…Many COVID-19 patients reveal a marked decrease in their lymphocyte counts, a condition that translates clinically into immunodepression and is common among…”
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Reduced platelet-lymphocyte ratio in a Saudi population with impaired fasting glycemia and hyperglycemia by Alfhili, Mohammad A., Alsughayyir, Jawaher, Basudan, Ahmed, Alfaifi, Mohammed, Awan, Zuhier A., Algethami, Mohammed R., Al-Sheikh, Yazeed A.

“…Diabetes mellitus (DM) is an inflammatory disorder characterized by elevated fasting blood glucose (FBG) with life-threatening complications. However, the…”
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Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury by Chhabra, Manu, Alsughayyir, Jawaher, Qureshi, M Saeed, Mallik, Mekhola, Ali, Jason M, Gamper, Ivonne, Moseley, Ellen L, Peacock, Sarah, Kosmoliaptsis, Vasilis, Goddard, Martin J, Linterman, Michelle A, Motallebzadeh, Reza, Pettigrew, Gavin J

“…Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer…”
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Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection by Alsughayyir, Jawaher, Chhabra, Manu, Qureshi, M Saeed, Mallik, Mekhola, Ali, Jason M, Gamper, Ivonne, Moseley, Ellen L, Peacock, Sarah, Kosmoliaptsis, Vasilis, Goddard, Martin J, Linterman, Michelle A, Motallebzadeh, Reza, Pettigrew, Gavin J

“…Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the…”
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Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant by Harper, Ines G., Ali, Jason M., Harper, Simon J.F., Wlodek, Elizabeth, Alsughayyir, Jawaher, Negus, Margaret C., Qureshi, M. Saeed, Motalleb-Zadeh, Reza, Saeb-Parsy, Kourosh, Bolton, Eleanor M., Bradley, J. Andrew, Clatworthy, Menna R., Conlon, Thomas M., Pettigrew, Gavin J.

“…Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the…”
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Monocyte-Lymphocyte Ratio and Dysglycemia: A Retrospective, Cross-Sectional Study of the Saudi Population by Alfhili, Mohammad A, Alsughayyir, Jawaher, Basudan, Ahmed M, Alsubki, Roua, Alqahtani, Saleh, Awan, Zuhier A, Algethami, Mohammed R, Al-Sheikh, Yazeed A

“…Background: Abnormalities in fasting blood glucose (FBG) resulting in hypoglycemia (OG), impaired fasting glycemia (IFG), or hyperglycemia (HG) arise from…”
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Isolated and Combined Effect of Age and Gender on Neutrophil-Lymphocyte Ratio in the Hyperglycemic Saudi Population by Alfhili, Mohammad A, Alsughayyir, Jawaher, Basudan, Ahmed, Ghneim, Hazem K, Aboul-Soud, Mourad A M, Marie, Mohammed, Dera, Ayed, Alfaifi, Mohammed, Alkhathami, Ali G, Awan, Zuhier A, Algethami, Mohammed R, Al-Sheikh, Yazeed A

“…Inflammation is pivotal to the pathogenesis of diabetes mellitus (DM), but pathological alterations of the neutrophil−lymphocyte ratio (NLR), an emerging…”
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Patterns of 25-Hydroxyvitamin D3, Calcium Status, and Anemia in the Saudi Population: A Cross-Sectional Study by Alfhili, Mohammad A, Basudan, Ahmed M, Alfaifi, Mohammed, Awan, Zuhier A, Algethami, Mohammed R, Alsughayyir, Jawaher

“…Emerging evidence suggests an intricate relationship between vitamin D, Ca , and inflammation-driven anemia. We, thus, investigated the patterns of serum…”
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Data regarding transplant induced germinal center humoral autoimmunity by Qureshi, M. Saeed, Alsughayyir, Jawaher, Chhabra, Manu, Ali, Jason M., Goddard, Martin J., Devine, Chris, Conlon, Thomas M., Linterman, Michelle A., Motallebzadeh, Reza, Pettigrew, Gavin J.

“…This data is related to the research article entitled “Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy”…”
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