Search Results - "Alston, Kevin"

A kit method for the high level synthesis of [ 211At]MABG by Vaidyanathan, Ganesan, Affleck, Donna J., Alston, Kevin L., Zhao, Xiao-Guang, Hens, Marc, Hunter, Duncan H., Babich, John, Zalutsky, Michael R.

“…meta-[ 211At]Astatobenzylguanidine ([ 211At]MABG), an analogue of meta-iodobenzylguanidine (MIBG) labeled with the α-emitter 211At, targets the norepinephrine…”
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A tin precursor for the synthesis of no-carrier-added [I]MIBG and [211At]MABG by Vaidyanathan, Ganesan, Affleck, Donna J., Alston, Kevin L., Zalutsky, Michael R.

“…Radioiodinated MIBG has shown considerable promise as an imaging agent for cardiac and oncologic applications, and also as a targeted radiotherapeutic for…”
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N ε-(3-[I]Iodobenzoyl)-Lys5-N α-maleimido-Gly1-GEEEK ([I]IB-Mal-d-GEEEK):  A Radioiodinated Prosthetic Group Containing Negatively Charged d-Glutamates for Labeling Internalizing Monoclonal Antibodies by Vaidyanathan, Ganesan, Alston, Kevin L, Bigner, Darrel D, Zalutsky, Michael R

“…Novel methods are needed for the radiohalogenation of cell-internalizing proteins and peptides because rapid loss of label occurs after lysosomal processing…”
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Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[ 211At]astato-3-pyridinecarboxylate by Reist, Craig J, Foulon, Catherine F, Alston, Kevin, Bigner, Darell D, Zalutsky, Michael R

“…Monoclonal antibodies (MAbs) such as the anti-epidermal growth factor variant III (EGFRvIII) MAb L8A4 are rapidly internalized, which can lead to rapid loss of…”
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Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate by REIST, C. J, GARG, P. K, ALSTON, K. L, BIGNER, D. D, ZALUTSKY, M. R

“…Monoclonal antibodies (mAbs) that internalize following binding to cell-surface receptors require radiolabeling approaches that minimize loss of radioactivity…”
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Catabolism of 4-fluoro-3-iodobenzylguanidine and meta-iodobenzylguanidine by SK-N-SH neuroblastoma cells by Vaidyanathan, Ganesan, Affleck, Donna J, Alston, Kevin L, Welsh, Philip, Zalutsky, Michael R

“…BACKGROUNDA fluorine substituted derivative of meta-iodobenzylguanidine (MIBG), 4-fluoro-3-iodobenzylguanidine (FIBG), is retained in SK-N-SH human…”
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Synthesis and Preliminary Biological Evaluation of (3-Iodobenzoyl)norbiotinamide and ((5-Iodo-3-pyridinyl)carbonyl)norbiotinamide:  Two Radioiodinated Biotin Conjugates with Improved Stability by Foulon, Catherine F, Alston, Kevin L, Zalutsky, Michael R

“…A new class of radioiodinated biotin conjugates is described in which the amido bond between biotin and the labeled prosthetic group is reversed. One…”
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Enhanced Binding and Inertness to Dehalogenation of α-Melanotropic Peptides Labeled Using N-Succinimidyl 3-Iodobenzoate by Garg, Pradeep K, Alston, Kevin L, Welsh, Philip C, Zalutsky, Michael R

“…Two peptides of potential utility for targeting melanoma cells, α-melanocyte-stimulating hormone (α-MSH) and its more potent analogue [Nle4,d-Phe7]-α-MSH, were…”
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Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods by Garg, Pradeep K, Alston, Kevin L, Zalutsky, Michael R

“…The F(ab')2 fragment of monoclonal antibody (MAb) Me1-14 was labeled with 125I using the Iodogen method and by reaction with N-succinimidyl…”
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Astatine-211-Labeled Biotin Conjugates Resistant to Biotinidase for Use in Pretargeted Radioimmunotherapy by Foulon, Catherine F, Alston, Kevin L, Zalutsky, Michael R

“…We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[ 211At]astatobenzoyl)norbiotinamide and ((5-[…”
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Nepsilon-(3-[I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies by Vaidyanathan, Ganesan, Alston, Kevin L, Bigner, Darrel D, Zalutsky, Michael R

“…Novel methods are needed for the radiohalogenation of cell-internalizing proteins and peptides because rapid loss of label occurs after lysosomal processing…”
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N ε -(3-[I]Iodobenzoyl)-Lys 5 - N α -maleimido-Gly 1 -GEEEK ([I]IB-Mal- d -GEEEK):  A Radioiodinated Prosthetic Group Containing Negatively Charged d -Glutamates for Labeling Internalizing Monoclonal Antibodies by Vaidyanathan, Ganesan, Alston, Kevin L., Bigner, Darrel D., Zalutsky, Michael R.

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N-[epsilon] (3- [I] Iodobenzoyl) -Lys5-N[alpha]-maleimido- Gly1-GEEEK ([I] IB-Mal-D-GEEEK): A Radioiodinated Prosthetic Group Containing Negatively Charged D-Glutamates for Labeling Internalizing Monoclonal Antibodies by Vaidyanathan, Ganesan, Alston, Kevin L, Bigner, Darrel D, Zalutsky, Michael R

“…Novel methods are needed for the radiohalogenation of cell-internalizing proteins and peptides because rapid loss of label occurs after lysosomal processing…”
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Meta-iodobenzylguanidine derivatives containing a second guanidine moiety by Vaidyanathan, Ganesan, Shankar, Sriram, Affleck, Donna J, Alston, Kevin, Norman, Joseph, Welsh, Philip, LeGrand, Holly, Zalutsky, Michael R

“…Radioiodinated meta-iodobenzylguanidine (MIBG) is used in the diagnosis and therapy of various neuroendocrine tumors. To investigate whether an additional…”
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High-level production of (alpha)-prticle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use by Zalutsky, Michael R, Xiao-Guang Zhao, Alston, Kevin L, Bigner, Darell

“…In vitro and in vivo studies in human glioma models suggest that the antitenascin monoclonal antibody 81C6 labeled with the 7.2-h-half-life alpha-particle…”
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High-Level Production of {alpha}-Particle-Emitting 211At and Preparation of 211At-Labeled Antibodies for Clinical Use by Zalutsky, Michael R, Zhao, Xiao-Guang, Alston, Kevin L, Bigner, Darell

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High-level production of α-particle-emitting 211At and preparation of 211At-labeled antibodies for clinical use by ZALUTSKY, Michael R, ZHAO, Xiao-Guang, ALSTON, Kevin L, BIGNER, Darell

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