Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes

Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(η6-p-cymene)RuCl2(CH3NH(CH2)4NH)]PF6, complex 1) or vitamin K3-thiosemicarbazone ([(η6-p-cymene)RuCl2(K3tsc)], complex 2) were synthesized starting from [(η6-p-cymene)2RuCl2]2 and the corresponding ligand...

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Bibliographic Details
Published in:	Journal of the Serbian Chemical Society Vol. 73; no. 6; pp. 619 - 630
Main Authors:	Grgurić-Šipka Sanja, Alshtewi Arbi Mohamed Al.M., Jeremić Dejan, Kaluđerović Goran N., Gómez-Ruiz Santiago, Žižak Željko, Juranić Zorica, Sabo Tibor J.
Format:	Journal Article
Language:	English
Published:	Serbian Chemical Society 01-01-2008
Subjects:	cytotoxic activity k3-thiosemicarbazone n-methylpiperazine p-cymene ruthenium(ii) complexes
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Summary:	Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(η6-p-cymene)RuCl2(CH3NH(CH2)4NH)]PF6, complex 1) or vitamin K3-thiosemicarbazone ([(η6-p-cymene)RuCl2(K3tsc)], complex 2) were synthesized starting from [(η6-p-cymene)2RuCl2]2 and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed “piano-stool” geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.
ISSN:	0352-5139 1820-7421
DOI:	10.2298/JSC0806619G