Search Results - "Alshammari, Qamar A"
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Label-free spectral imaging to study drug distribution and metabolism in single living cells
Published in Scientific reports (01-02-2021)“…During drug development, evaluation of drug and its metabolite is an essential process to understand drug activity, stability, toxicity and distribution…”
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2
Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines
Published in Journal of enzyme inhibition and medicinal chemistry (01-12-2023)“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) protein tyrosine kinases co-expressed in various cancers such as…”
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3
Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations
Published in Metabolites (17-01-2023)“…Antioxidant small molecules can prevent or delay the oxidative damage caused by free radicals. Herein, a structure-based hybridization of two natural…”
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Maternal and Fetal Outcome of COVID-19 Infection among Pregnant Women
Published in Medicina (Kaunas, Lithuania) (12-10-2024)“…: Pregnant women face an increased risk of experiencing negative consequences due to COVID-19 infection. Our study aimed to identify outcomes for both mothers…”
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Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives
Published in Pharmaceuticals (Basel, Switzerland) (28-12-2022)“…Co-expression of the epidermal growth factor receptor (EGFR, also known as ErbB1) and human epidermal growth factor receptor 2 (HER2) has been identified as a…”
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Cytotoxic activity of non-specific lipid transfer protein (nsLTP1) from Ajwain (Trachyspermum ammi) seeds
Published in BMC complementary and alternative medicine (16-05-2022)“…Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties,…”
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Natural product-derived ALK inhibitors for treating ALK-driven lung cancers: an in silico study
Published in Molecular diversity (08-08-2024)“…Anaplastic lymphoma kinase (ALK)-driven lung cancer represents a critical therapeutic target, demanding innovative approaches for the identification of…”
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Unraveling the mechanisms of glioblastoma's resistance: investigating the influence of tumor suppressor p53 and non-coding RNAs
Published in Naunyn-Schmiedeberg's archives of pharmacology (30-10-2024)“…Glioblastoma (GB) is one of the most fatal CNS malignancies, and its high resistance to therapy and poor outcomes have made it one of the primary challenges in…”
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9
The use of advanced spectral imaging to reveal nanoparticle identity in biological samples
Published in Nanoscale (17-03-2022)“…Nanoparticles (NPs) have been used in drug delivery therapies, medical diagnostic strategies, and as current Covid-19 vaccine carriers. Many microscope-based…”
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Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
Published in Inflammopharmacology (01-12-2023)“…Chronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and autoimmune disorders, and is…”
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Convenient and highly efficient adsorption of diosmetin from lemon peel by magnetic surface molecularly imprinted polymers
Published in Journal of materials science & technology (10-03-2025)“…•A magnetic imprinted polymer was prepared.•Computational simulation was performed to select functional monomers.•Selectively adsorbing diosmetin was achieved…”
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12
Cytotoxic activity of non-specific lipid transfer protein seeds
Published in BMC complementary medicine and therapies (16-05-2022)“…Background Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological…”
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Identification of Molecules by Spectral Imaging
Published 01-01-2019“…Spectral imaging is a powerful technique which uses the wavelength to identify/quantify the exact location and amount of the molecules. It facilitates the…”
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Dissertation