Search Results - "Alshaer, Mohammad"

Another trial for the TARGET trial by Alshaer, Mohammad H., Peloquin, Charles A.

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Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics by Alshaer, Mohammad H, Goutelle, Sylvain, Santevecchi, Barbara A, Shoulders, Bethany R, Venugopalan, Veena, Cherabuddi, Kartikeya, Liu, Jiajun, Kiel, Patrick J, Roberts, Jason A, Sime, Fekade Bruck, Scheetz, Marc H, Neely, Michael N, Peloquin, Charles A

“…Cefepime is the second most common cephalosporin used in U.S. hospitals. We aim to develop and validate a cefepime population pharmacokinetic (PK) model and…”
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Cefepime pharmacokinetics in adult extracorporeal membrane oxygenation patients by Zheng, Lily, Alshaer, Mohammad H., Peloquin, Charles, Venugopalan, Veena, Alnuaimat, Hassan M., Converse, Maureen

“…The impact of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics/dynamics (PK/PD) of beta-lactam antibiotics have not been well studied in…”
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Clinical Pharmacokinetics and Pharmacodynamics of Cefepime by Pais, Gwendolyn M., Chang, Jack, Barreto, Erin F., Stitt, Gideon, Downes, Kevin J., Alshaer, Mohammad H., Lesnicki, Emily, Panchal, Vaidehi, Bruzzone, Maria, Bumanglag, Argyle V., Burke, Sara N., Scheetz, Marc H.

“…Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-positive and Gram-negative pathogens. It is generally administered as…”
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Beta-lactam target attainment and associated outcomes in patients with bloodstream infections by Alshaer, Mohammad H., Maranchick, Nicole, Alexander, Kaitlin M., Manigaba, Kayihura, Shoulders, Bethany R., Felton, Timothy W., Mathew, Sumith K., Peloquin, Charles A.

“…•fT>4 × MIC was a significant predictor of negative blood culture on day 7•Patients who achieved 100% fT>4 × MIC had a shorter time to negative blood…”
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Implementation of a β-lactam therapeutic drug monitoring program: Experience from a large academic medical center by Venugopalan, Veena, Hamza, Malva, Santevecchi, Barbara, DeSear, Kathryn, Cherabuddi, Kartikeya, Peloquin, Charles A, Alshaer, Mohammad H

“…Abstract Purpose To describe the implementation and operationalization of a β-lactam (BL) therapeutic drug monitoring (TDM) program at a large academic center…”
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Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis by Maranchick, Nicole F, Alshaer, Mohammad H, Smith, Alison G C, Avaliani, Teona, Gujabidze, Mariam, Bakuradze, Tinatin, Sabanadze, Shorena, Avaliani, Zaza, Kipiani, Maia, Peloquin, Charles A, Kempker, Russell R

“…Tuberculosis meningitis (TBM) is the most lethal form of TB. It is difficult to treat in part due to poor or uncertain drug penetration into the central…”
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Therapeutic drug monitoring in cystic fibrosis and associations with pulmonary exacerbations and lung function by Katz, Jason Brandon, Shah, Purav, Trillo, Cesar A., Alshaer, Mohammad H., Peloquin, Charles, Lascano, Jorge

“…Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy have resulted in longer life expectancies, yet pulmonary exacerbations remain a…”
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Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Potential Usefulness by Kempker, Russell R, Smith, Alison G C, Avaliani, Teona, Gujabidze, Mariam, Bakuradze, Tinatin, Sabanadze, Shorena, Avaliani, Zaza, Collins, Jeffrey M, Blumberg, Henry M, Alshaer, Mohammad H, Peloquin, Charles A, Kipiani, Maia

“…The ability of antituberculosis drugs to cross the blood-brain barrier and reach the central nervous system is critical to their effectiveness in treating…”
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Making the case for precision dosing: visualizing the variability of cefepime exposures in critically ill adults by Chang, Jack, Liu, Jiajun, Alshaer, Mohammad H, Venugopalan, Veena, Maranchick, Nicole, Peloquin, Charles A, Rhodes, Nathaniel J, Scheetz, Marc H

“…Abstract Objective To investigate and describe the variability in cefepime exposures among ‘real-world’, critically ill patients by using population…”
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International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists: An executive summary by Hong, Lisa T., Downes, Kevin J., FakhriRavari, Alireza, Abdul‐Mutakabbir, Jacinda C., Kuti, Joseph L., Jorgensen, Sarah, Young, David C., Alshaer, Mohammad H., Bassetti, Matteo, Bonomo, Robert A., Gilchrist, Mark, Jang, Soo Min, Lodise, Thomas, Roberts, Jason A., Tängdén, Thomas, Zuppa, Athena, Scheetz, Marc H.

“…Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent…”
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Using Machine Learning To Define the Impact of Beta-Lactam Early and Cumulative Target Attainment on Outcomes in Intensive Care Unit Patients with Hospital-Acquired and Ventilator-Associated Pneumonia by Alshaer, Mohammad H, Maranchick, Nicole, Bai, Chen, Maguigan, Kelly L, Shoulders, Bethany, Felton, Timothy W, Mathew, Sumith K, Mardini, Mamoun T, Peloquin, Charles A

“…Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the most common intensive care unit (ICU) infections. We aimed to evaluate the…”
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International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists by Hong, Lisa T., Downes, Kevin J., FakhriRavari, Alireza, Abdul‐Mutakabbir, Jacinda C., Kuti, Joseph L., Jorgensen, Sarah, Young, David C., Alshaer, Mohammad H., Bassetti, Matteo, Bonomo, Robert A., Gilchrist, Mark, Jang, Soo Min, Lodise, Thomas, Roberts, Jason A., Tängdén, Thomas, Zuppa, Athena, Scheetz, Marc H.

“…Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent…”
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Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis by Graciaa, Daniel S, Kipiani, Maia, Magee, Matthew J, Mikiashvili, Lali, Barbakadze, Ketevan, Bablishvili, Nino, Auld, Sara C, Alghamdi, Wael A, Alshaer, Mohammad H, Peloquin, Charles A, Avaliani, Zaza, Blumberg, Henry M, Kempker, Russell R

“…Although linezolid is effective for multidrug-resistant TB (MDR-TB) tuberculosis treatment, it is associated with cytopenias after 4 weeks of administration…”
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A Randomized Clinical Trial of Bayesian-Guided Beta-Lactam Infusion Strategy and Associated Bacterial Resistance and Clinical Outcomes in Patients With Severe Pneumonia by Maranchick, Nicole F, Trillo-Alvarez, Cesar, Kariyawasam, Vidhu, Venugopalan, Veena, Kwara, Awewura, Rand, Kenneth, Peloquin, Charles A, Alshaer, Mohammad H

“…Antimicrobial resistance is a growing health concern worldwide. The objective of this study was to evaluate the effect of beta-lactam infusion on the emergence…”
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Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue by Alshaer, Mohammad H, Barlow, Brooke, Maranchick, Nicole, Moser, Miriam, Gramss, Leon, Burgmann, Heinz, Jalali, Valentin Al, Wölfl-Duchek, Michael, Jäger, Walter, Poschner, Stefan, Plöchl, Walter, Reinprecht, Andrea, Rössler, Karl, Gruber, Andreas, Zeitlinger, Markus, Peloquin, Charles A, Hosmann, Arthur

“…Meropenem is a broad spectrum carbapenem used for the treatment of cerebral infections. There is a need for data describing meropenem pharmacokinetics (PK) in…”
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Use of therapeutic drug monitoring to characterize cefepime‐related neurotoxicity by Venugopalan, Veena, Casaus, Danielle, Kainz, Leonie, Slaton, Cara N., Hurst, Natalie, Bruzzone, Maria, Hu, Calvin, Sword, Gabriel, Cherabuddi, Kartikeya, Iovine, Nicole, Liu, Jiajun, Scheetz, Marc H., Rhodes, Nathaniel, Maranchick, Nicole, Peloquin, Charles A., Klinker, Kenneth, Alshaer, Mohammad H.

“…Study Objectives Data evaluating cefepime thresholds associated with neurotoxicity remain limited. The objectives of this study were to evaluate the incidence…”
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The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation by Jin, Yutong, Benkeser, David, Kipiani, Maia, Maranchick, Nicole F., Mikiashvili, Lali, Barbakadze, Ketevan, Avaliani, Zaza, Alghamdi, Wael A., Alshaer, Mohammad H., Peloquin, Charles A., Blumberg, Henry M, Kempker, Russell R.

“…•Among an observational cohort of patient being treated for drug-resistant tuberculosis, bedaquiline and delamanid based treatment regimens had a modest and…”
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Pharmacokinetic-Pharmacodynamic Determinants of Clinical Outcomes for Rifampin-Resistant Tuberculosis: A Multisite Prospective Cohort Study by Heysell, Scott K, Mpagama, Stellah G, Ogarkov, Oleg B, Conaway, Mark, Ahmed, Shahriar, Zhdanova, Svetlana, Pholwat, Suporn, Alshaer, Mohammad H, Chongolo, Anna M, Mujaga, Buliga, Sariko, Margaretha, Saba, Sabrina, Rahman, S M Mazidur, Uddin, Mohammad Khaja Mafij, Suzdalnitsky, Alexey, Moiseeva, Elena, Zorkaltseva, Elena, Koshcheyev, Mikhail, Vitko, Serhiy, Mmbaga, Blandina T, Kibiki, Gibson S, Pasipanodya, Jotam G, Peloquin, Charles A, Banu, Sayera, Houpt, Eric R

“…Abstract Background Rifampin-resistant and/or multidrug-resistant tuberculosis (RR/MDR-TB) treatment requires multiple drugs, and outcomes remain suboptimal…”
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Utilization of cefepime therapeutic drug monitoring in febrile neutropenia patients with hematologic malignancies by Lodl, Emma F, Alshaer, Mohammad H, Adams, C. Brooke, Richards, Ashley, Peloquin, Charles, Venugopalan, Veena

“…Introduction Cefepime is a fourth-generation cephalosporin and is a workhorse for the empiric treatment of febrile neutropenia (FN). Beta-lactam therapeutic…”
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