Hematologic markers of distant metastases in gastric cancer

High neutrophil-lymphocyte ratio (NLR) is associated with poor overall survival (OS) in gastric cancer. This study evaluates whether NLR, in addition to other parameters including absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophil count (AEC), absolute monocyte cou...

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Bibliographic Details
Published in:	Journal of gastrointestinal oncology Vol. 10; no. 3; pp. 529 - 536
Main Authors:	Abu-Shawer, Osama, Abu-Shawer, Mohammad, Haimour, Ayman, Alhouri, Abdullah, Alkhatib, Ala'a Aldeen, Abki, Musaab, Alqaisi, Omar, Hamdan, Omar, Alsaqri, Rahaf, Ismail, Saeed, Altamimi, Tamer, Al-Hussaini, Maysa
Format:	Journal Article
Language:	English
Published:	China AME Publishing Company 01-06-2019
Subjects:	Original neutrophil-lymphocyte ratio (NLR) Gastric cancer distant metastases
Online Access:	Get full text
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Summary:	High neutrophil-lymphocyte ratio (NLR) is associated with poor overall survival (OS) in gastric cancer. This study evaluates whether NLR, in addition to other parameters including absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophil count (AEC), absolute monocyte count (AMC), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) are associated with distant metastases, a common and poor prognostic feature of gastric cancer. Clinical data from 502 gastric cancer patients treated at King Hussein Cancer Center (Amman, Jordan) have been retrospectively reviewed. We examined the association between ANC, ALC, AEC, AMC, NLR, MLR and PLR with the baseline distant metastases and OS. Receiver operating characteristic (ROC) curve analysis was utilized to determine the optimal NLR cutoff value for association with distant metastases. Univariate and multivariate analyses showed that patients with high baseline NLR (≥3.9) had more distant metastases on presentation than patients with low NLR (<3.9), (P value: 0.0001 and 0.0005, respectively). Furthermore, patients with high baseline ANC (≥6,015/µL), AEC (≥215/µL), PLR (≥0.15) had more distant metastases in comparison to patients with low baseline ANC (<6,015/µL), AEC (<215/µL), PLR (<0.15) (P value: 0.024, 0.001, and 0.001, respectively). High ANC, NLR, MLR and PLR are associated with poor OS (P value: 0.046, 0.0003, 0.027, and <0.0001, respectively). High ANC, AEC, NLR, and PLR are associated with distant metastases on presentation in gastric cancer. In the era of cancer immunotherapy, whether these immune phenomena predict the response of gastric cancer to immunotherapy is unknown.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributions: (I) Conception and design: O Abu-Shawer, M Al-Hussaini; (II) Administrative support: M Al-Hussaini; (III) Provision of study materials or patients: A Haimour, M Al-Hussaini; (IV) Collection and assembly of data: A Alhouri, AA Alkhatib, M Abki, O Alqaisi, O Hamdan, R Alsaqri, S Ismail, T Altamimi; (V) Data analysis and interpretation: O Abu-Shawer, M Abu-Shawer; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:	2078-6891 2219-679X
DOI:	10.21037/jgo.2019.01.12