Search Results - "Alrhmoun, Saleh"

The Role of Tumor-Associated Antigen HER2/neu in Tumor Development and the Different Approaches for Using It in Treatment: Many Choices and Future Directions by Alrhmoun, Saleh, Sennikov, Sergey

“…The treatment of HER2-positive cancers has changed significantly over the past ten years thanks to a significant number of promising new approaches that have…”
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A subpopulation of human bone marrow erythroid cells displays a myeloid gene expression signature similar to that of classic monocytes by Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Shevchenko, Julia, Volynets, Marina, Alrhmoun, Saleh, Nazarov, Kirill, Denisova, Vera, Sennikov, Sergey

“…Erythroid cells, serving as progenitors and precursors to erythrocytes responsible for oxygen transport, were shown to exhibit an immunosuppressive and…”
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Acute blood loss in mice forces differentiation of both CD45-positive and CD45-negative erythroid cells and leads to a decreased CCL3 chemokine production by bone marrow erythroid cells by Nazarov, Kirill, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Volynets, Marina, Shevchenko, Julia, Sennikov, Sergey

“…Hemorrhage, a condition that accompanies most physical trauma cases, remains an important field of study, a field that has been extensively studied in the…”
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Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells by Perik-Zavodskaia, Olga, Perik-Zavodskii, Roman, Nazarov, Kirill, Volynets, Marina, Alrhmoun, Saleh, Shevchenko, Julia, Sennikov, Sergey

“…Mouse erythropoiesis is a multifaceted process involving the intricate interplay of proliferation, differentiation, and maturation of erythroid cells, leading…”
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TCR-T cell therapy: current development approaches, preclinical evaluation, and perspectives on regulatory challenges by Golikova, Elena A, Alshevskaya, Alina A, Alrhmoun, Saleh, Sivitskaya, Natalia A, Sennikov, Sergey V

“…TCR-T cell therapy represents a promising advancement in adoptive immunotherapy for cancer treatment. Despite its potential, the development and preclinical…”
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Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-α by Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Perik-Zavodskii, Roman, Zhukova, Julia, Lopatnikova, Julia, Volynets, Marina, Alshevskaya, Alina, Sennikov, Sergey

“…This research delves into the intricate landscape of tumor necrosis factor-alpha (TNF-α) signaling, a multi-functional cytokine known for its diverse cellular…”
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Murine Placental Erythroid Cells Are Mainly Represented by CD45 + Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines by Nazarov, Kirill, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Volynets, Marina, Shevchenko, Julia, Sennikov, Sergey

“…Erythroid cells are emerging players in immunological regulation that have recently been shown to play a crucial role in fetomaternal tolerance in mice. In…”
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Single-cell multi-omics reveal stage of differentiation and trajectory-dependent immunity-related gene expression patterns in human erythroid cells by Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Volynets, Marina, Shevchenko, Julia, Nazarov, Kirill, Denisova, Vera, Sennikov, Sergey

“…The role of Erythroid cells in immune regulation and immunosuppression is one of the emerging topics in modern immunology that still requires further…”
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Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro -effective clonotype via profiling of thousands of MAGE-A3-specific T-cells by Sennikov, Sergey, Volynets, Marina, Alrhmoun, Saleh, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Fisher, Marina, Lopatnikova, Julia, Shevchenko, Julia, Nazarov, Kirill, Philippova, Julia, Alsalloum, Alaa, Kurilin, Vasily, Silkov, Alexander

“…Adoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested…”
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Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4 by Alsalloum, Alaa, Shevchenko, Julia, Fisher, Marina, Philippova, Julia, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Lopatnikova, Julia, Vasily, Kurilin, Volynets, Marina, Zavjalov, Evgenii, Solovjeva, Olga, Akahori, Yasushi, Shiku, Hiroshi, Silkov, Alexander, Sennikov, Sergey

“…TCR-like chimeric antigen receptor (CAR-T) cell therapy has emerged as a game-changing strategy in cancer immunotherapy, offering a broad spectrum of potential…”
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Human Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression by Perik-Zavodskii, Roman, Perik-Zavodskaya, Olga, Shevchenko, Yulia, Alrhmoun, Saleh, Volynets, Marina, Zaitsev, Konstantin, Sennikov, Sergey

“…Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens’ (TSAs) gene expression, a key event in the…”
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Phenotypic Alterations in Erythroid Nucleated Cells of Spleen and Bone Marrow in Acute Hypoxia by Nazarov, Kirill, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Alrhmoun, Saleh, Volynets, Marina, Shevchenko, Julia, Sennikov, Sergey

“…Hypoxia leads to metabolic changes at the cellular, tissue, and organismal levels. The molecular mechanisms for controlling physiological changes during…”
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Immune Transcriptome Study of Human Nucleated Erythroid Cells from Different Tissues by Single-Cell RNA-Sequencing by Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Shevchenko, Julia, Denisova, Vera, Alrhmoun, Saleh, Volynets, Marina, Tereshchenko, Valeriy, Zaitsev, Konstantin, Sennikov, Sergey

“…Nucleated erythroid cells (NECs) are the precursors of erythrocytes. They can be found in various hematopoietic tissues or in the blood. Recently, they have…”
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Anticancer Potential of Pyridoxine-Based Doxorubicin Derivatives: An In Vitro Study by Karwt, Rawdah, Bondar, Oksana V, Pugachev, Mikhail V, Mohammad, Tharaa, Kadyrova, Aisylu S, Pavelyev, Roman S, Alrhmoun, Saleh, Gnezdilov, Oleg I, Shtyrlin, Yurii G

“…Doxorubicin (DOX) is a prevalent anticancer agent; however, it is unfortunately characterized by high cardiotoxicity, myelosuppression, and multiple other side…”
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TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors by Alsalloum, Alaa, Alrhmoun, Saleh, Shevchenko, Julia, Fisher, Marina, Philippova, Julia, Perik-Zavodskii, Roman, Perik-Zavodskaia, Olga, Lopatnikova, Julia, Kurilin, Vasily, Volynets, Marina, Akahori, Yasushi, Shiku, Hiroshi, Silkov, Alexander, Sennikov, Sergey

“…Adoptive T-cell therapies tailored for the treatment of solid tumors encounter intricate challenges, necessitating the meticulous selection of specific target…”
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TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model by Alshevskaya, Alina A, Lopatnikova, Julia A, Zhukova, Julia V, Perik-Zavodskaia, Olga Y, Alrhmoun, Saleh, Obleukhova, Irina A, Matveeva, Anna K, Savenkova, Darya A, Imatdinov, Ilnaz R, Yudkin, Dmitry V, Sennikov, Sergey V

“…One of the mechanisms regulating the biological activity of tumor necrosis factor (TNF) in cells is the co-expression of TNFR1/TNFR2 receptors. A model with a…”
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