Search Results - "Alrawashdeh, Sara"

Computational insights into the mechanisms underlying structural destabilization and recovery in trafficking-deficient hERG mutants by AlRawashdeh, Sara, Mosa, Farag E S, Barakat, Khaled H

“…Cardiovascular diseases are a major global health concern, responsible for a significant number of deaths each year, often linked to cardiac arrhythmias…”
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Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds by Atatreh, Noor, Youssef, Amal M., Ghattas, Mohammad A., Al Sorkhy, Mohammad, Alrawashdeh, Sara, Al-Harbi, Khaled B., El-Ashmawy, Ibrahim M., Almundarij, Tariq I., Abdelghani, Amani A., Abd-El-Aziz, Alaa S.

“…The present work describes the design and synthesis of novel series of ten pyrazolo[3,4-d]pyrazolo derivatives. Four compounds 3a, 3d, 4d and 4f were notable…”
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Structural analysis of hERG channel blockers and the implications for drug design by AlRawashdeh, Sara, Chandrasekaran, Suryanarayanan, Barakat, Khaled H.

“…The repolarizing current (Ikr) produced by the hERG potassium channel forms a major component of the cardiac action potential and blocking this current by…”
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Molecular Dynamics Simulations of Aggregate-Enzyme Solutions by Alrawashdeh, Sara

“…The formation of small molecule aggregates in aqueous solution is troublesome in the process of drug discovery. A high percentage of false positives during the…”
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Investigating the Aryl Hydrocarbon Receptor Agonist/Antagonist Conformational Switch Using Well-Tempered Metadynamics Simulations by Mosa, Farag E. S., AlRawashdeh, Sara, El-Kadi, Ayman O. S., Barakat, Khaled

“…The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular…”
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