Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. : To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. : The self...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 7; p. 1703
Main Authors:	Kazi, Mohsin, Shahba, Ahmad A, Alrashoud, Saad, Alwadei, Majed, Sherif, Abdelrahman Y, Alanazi, Fars K
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 08-04-2020 MDPI
Subjects:	Administration, Oral Adsorption Alkaloids - administration & dosage Alkaloids - chemistry Benzodioxoles - administration & dosage Benzodioxoles - chemistry bio-SNEDDS Bioavailability Biocompatible Materials - chemistry Biological activity Calorimetry Calorimetry, Differential Scanning combination therapy Curcumin Curcumin - administration & dosage Curcumin - chemistry curcumin and piperine Differential scanning calorimetry Dissolution dissolution improvement Droplets Drug delivery Drug Delivery Systems Drug development Drugs Emulsions - chemistry Equilibrium Fourier analysis Fourier transforms Health care Hydrogen-Ion Concentration Infrared spectroscopy Lipids Nanoparticles - chemistry Oils & fats Particle Size Piperidines - administration & dosage Piperidines - chemistry Piperine Polyunsaturated Alkamides - administration & dosage Polyunsaturated Alkamides - chemistry Scanning electron microscopy self-nanoemulsifying drug delivery systems (SNEDDS) Solidification solidification technique Solids Solubilization Spectroscopy, Fourier Transform Infrared Spectrum analysis Static Electricity X ray powder diffraction X-Ray Diffraction bio-SNEDDS combination therapy dissolution improvement self-nanoemulsifying drug delivery systems (SNEDDS) curcumin and piperine solidification technique
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Summary:	: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. : To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. : The self-emulsifying properties of apricot, avocado, black seed and seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl and Neusilin at 1:1 / ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS. : The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25071703