Comparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia

Aging-related sarcopenia is a degenerative loss of strength and skeletal muscle mass that impairs quality of life. Evaluating NUDT3 gene and myogenin expression as new diagnostic tools in sarcopenia. Also, comparing the concomitant treatment of resistance exercise (EX) and creatine monohydrate (CrM)...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; p. 9798
Main Authors:	Elgizawy, Eman I., Amer, Ghada S., Ali, Eman A., Alqalashy, Fatma S., Ibrahim, Marwa M., Latif, Asmaa A. Abdel, Shaban, Anwar M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29-04-2024 Nature Publishing Group Nature Portfolio
Subjects:	631/443 631/45 631/80 Aged rats Aging Animals Antioxidants Antioxidants - metabolism Coenzyme Q 10 Coenzyme Q10 Creatine Creatine kinase Creatine Kinase - blood Creatine monohydrate Electromyography Exercise Gastrocnemius muscle Gene expression Humanities and Social Sciences Kinases Lipids Male multidisciplinary Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Myogenin Myogenin - genetics Myogenin - metabolism Oxidative stress Physical Conditioning, Animal Pyrophosphatases - genetics Pyrophosphatases - metabolism Quality of life Rats Rats, Wistar Resistance Training Sarcopenia Sarcopenia - drug therapy Sarcopenia - metabolism Science Science (multidisciplinary) Skeletal muscle Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use Oxidative stress Aged rats Exercise Coenzyme Q 10 Creatine monohydrate
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Summary:	Aging-related sarcopenia is a degenerative loss of strength and skeletal muscle mass that impairs quality of life. Evaluating NUDT3 gene and myogenin expression as new diagnostic tools in sarcopenia. Also, comparing the concomitant treatment of resistance exercise (EX) and creatine monohydrate (CrM) versus single therapy by EX, coenzyme Q10 (CoQ10), and CrM using aged rats. Sixty male rats were equally divided into groups. The control group, aging group, EX-treated group, the CoQ10 group were administered (500 mg/kg) of CoQ10, the CrM group supplied (0.3 mg/kg of CrM), and a group of CrM concomitant with resistance exercise. Serum lipid profiles, certain antioxidant markers, electromyography (EMG), nudix hydrolase 3 (NUDT3) expression, creatine kinase (CK), and sarcopenic index markers were measured after 12 weeks. The gastrocnemius muscle was stained with hematoxylin–eosin (H&E) and myogenin. The EX-CrM combination showed significant improvement in serum lipid profile, antioxidant markers, EMG, NUDT3 gene, myogenin expression, CK, and sarcopenic index markers from other groups. The NUDT3 gene and myogenin expression have proven efficient as diagnostic tools for sarcopenia. Concomitant treatment of CrM and EX is preferable to individual therapy because it reduces inflammation, improves the lipid serum profile, promotes muscle regeneration, and thus has the potential to improve sarcopenia.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-59884-w