Search Results - "Alpsoy, Aktan"

Autocrine Fibronectin Inhibits Breast Cancer Metastasis by Shinde, Aparna, Libring, Sarah, Alpsoy, Aktan, Abdullah, Ammara, Schaber, James A, Solorio, Luis, Wendt, Michael K

“…Both epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are linked to metastasis via their ability to increase invasiveness…”
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Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells by Cai, Bo, Kim, Dongwook, Akhand, Saeed, Sun, Yixing, Cassell, Robert J, Alpsoy, Aktan, Dykhuizen, Emily C, Van Rijn, Richard M, Wendt, Michael K, Krusemark, Casey J

“…We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach…”
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A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation by Wang, Sijie, Alpsoy, Aktan, Sood, Surbhi, Ordonez‐Rubiano, Sandra Carolina, Dhiman, Alisha, Sun, Yixing, Jiao, Guanming, Krusemark, Casey J., Dykhuizen, Emily C.

“…Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic development and cancer progression. PcG proteins form Polycomb…”
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A chemoproteomic portrait of the oncometabolite fumarate by Kulkarni, Rhushikesh A., Bak, Daniel W., Wei, Darmood, Bergholtz, Sarah E., Briney, Chloe A., Shrimp, Jonathan H., Alpsoy, Aktan, Thorpe, Abigail L., Bavari, Arissa E., Crooks, Daniel R., Levy, Michaella, Florens, Laurence, Washburn, Michael P., Frizzell, Norma, Dykhuizen, Emily C., Weerapana, Eranthie, Linehan, W. Marston, Meier, Jordan L.

“…Hereditary cancer disorders often provide an important window into novel mechanisms supporting tumor growth. Understanding these mechanisms thus represents a…”
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Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms by Alpsoy, Aktan, Yasa, Seda, Gündüz, Ufuk

“…Abstract Purpose Acquired or intrinsic drug resistance is one of the major handicaps in the success of chemotherapy. Etoposide is a topoisomerase II poison…”
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At the Crossroad of Gene Regulation and Genome Organization: Potential Roles for ATP-Dependent Chromatin Remodelers in the Regulation of CTCF-Mediated 3D Architecture by Alpsoy, Aktan, Sood, Surbhi, Dykhuizen, Emily C

“…In higher order organisms, the genome is assembled into a protein-dense structure called chromatin. Chromatin is spatially organized in the nucleus through…”
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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma by Carcamo, Saul, Nguyen, Christie B., Grossi, Elena, Filipescu, Dan, Alpsoy, Aktan, Dhiman, Alisha, Sun, Dan, Narang, Sonali, Imig, Jochen, Martin, Tiphaine C., Parsons, Ramon, Aifantis, Iannis, Tsirigos, Aristotelis, Aguirre-Ghiso, Julio A., Dykhuizen, Emily C., Hasson, Dan, Bernstein, Emily

“…ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape…”
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Identification of SWI/SNF Subcomplex GBAF Presence, Intra-Complex Interactions, and Transcriptional Dynamics during Early Porcine Development by Innis, Sarah, Alpsoy, Aktan, Crodian, Jennifer, Tseng, Yu-Chun, Dykhuizen, Emily, Cabot, Birgit, Cabot, Ryan

“…Understanding the complex interplay between genetics and environmental factors is vital for enhancing livestock production efficiency while safeguarding animal…”
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Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8 by Milosevich, Natalia, Wilson, Chelsea R., Brown, Tyler M., Alpsoy, Aktan, Wang, Sijie, Connelly, Katelyn E., Sinclair, Kirsten A. D., Ponio, Felino R., Hof, Rebecca, Dykhuizen, Emily C., Hof, Fraser

“…Methyllysine reader proteins bind to methylated lysine residues and alter gene transcription by changing either the compaction state of chromatin or by the…”
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Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes by Alpsoy, Aktan, Dykhuizen, Emily C.

“…The mammalian SWI/SNF chromatin remodeling complex is a heterogeneous collection of related protein complexes required for gene regulation and genome…”
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IκBζ is a dual-use coactivator of NF-κB and POU transcription factors by Alpsoy, Aktan, Wu, Xiaoli S, Pal, Sujay, Klingbeil, Olaf, Kumar, Pramod, El Demerdash, Osama, Nalbant, Benan, Vakoc, Christopher R

“…OCA-B, OCA-T1, and OCA-T2 belong to a family of coactivators that bind to POU transcription factors (TFs) to regulate gene expression in immune cells. Here, we…”
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BRD9 Is a Critical Regulator of Androgen Receptor Signaling and Prostate Cancer Progression by Alpsoy, Aktan, Utturkar, Sagar M, Carter, Benjamin C, Dhiman, Alisha, Torregrosa-Allen, Sandra E, Currie, Melanie P, Elzey, Bennett D, Dykhuizen, Emily C

“…Switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complexes are critical regulators of chromatin dynamics during transcription, DNA replication, and…”
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Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association by Connelly, Katelyn E, Weaver, Tyler M, Alpsoy, Aktan, Gu, Brian X, Musselman, Catherine A, Dykhuizen, Emily C

“…Abstract Polycomb repressive complex 1 (PRC1) is critical for mediating gene repression during development and adult stem cell maintenance. Five CBX…”
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Protein kinase D2 silencing reduced motility of doxorubicin-resistant MCF7 cells by Alpsoy, Aktan, Gündüz, Ufuk

“…Success of chemotherapy is generally impaired by multidrug resistance, intrinsic resistance, or acquired resistance to functionally and structurally irrelevant…”
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Characterization of Novel SWI/SNF Chromatin Remodeling Complex (GBAF) in Health and Disease by Alpsoy, Aktan

“…In eukaryotic systems, the genetic material of the cell –DNA– is packed into a protein-dense structure called chromatin. Chromatin structure is critical for…”
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A Novel CRISPR/Cas9‐Based Cellular Model to Explore Adenylyl Cyclase and Cyclic AMP Signaling by Soto‐Velasquez, Monica, Alpsoy, Aktan, Dykhuizen, Emily C., Watts, Val J.

“…Functional characterization of adenylyl cyclase (AC) isoforms has proven to be challenging in mammalian cell systems due to the endogenous expression of…”
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Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma by Maia-Silva, Diogo, Cunniff, Patrick J., Schier, Allison C., Skopelitis, Damianos, Trousdell, Marygrace C., Moresco, Philip, Gao, Yuan, Kechejian, Vahag, He, Xue-Yan, Sahin, Yunus, Wan, Ledong, Alpsoy, Aktan, Liverpool, Jynelle, Krainer, Adrian R., Egeblad, Mikala, Spector, David L., Fearon, Douglas T., dos Santos, Camila O., Taatjes, Dylan J., Vakoc, Christopher R.

“…The presence of basal lineage characteristics signifies hyperaggressive human adenocarcinomas of the breast, bladder and pancreas. However, the biochemical…”
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A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling by Soto-Velasquez, Monica, Hayes, Michael P, Alpsoy, Aktan, Dykhuizen, Emily C, Watts, Val J

“…Functional characterization of adenylyl cyclase (AC) isoforms has proven challenging in mammalian cells because of the endogenous expression of multiple AC…”
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The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability by Torres-Zelada, Eliana F, Stephenson, Robert E, Alpsoy, Aktan, Anderson, Benjamin D, Swanson, Selene K, Florens, Laurence, Dykhuizen, Emily C, Washburn, Michael P, Weake, Vikki M

“…Metazoans contain two homologs of the Gcn5-binding protein Ada2, Ada2a and Ada2b, which nucleate formation of the ATAC and SAGA complexes, respectively. In ,…”
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Poly (I:C)- and doxorubicin-loaded magnetic dendrimeric nanoparticles affect the apoptosis-related gene expressions in MCF-7 cells by KHODADUST, Rouhollah, ALPSOY, Aktan, ÜNSOY, Gözde, GÜNDÜZ, Ufuk

“…Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and…”
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