Construction of a corresponding empirical model to bridge thermal properties and synthesis of thermoresponsive poloxamines

The thermoresponsive properties of poloxamine (tetra-branch PEO-PPO block copolymer) hydrogels are related to several variables. Of particular interest to this study were the molecular weight of the polymer, the molar ratio between PEO and PPO blocks, and the concentration of the aqueous solution. A...

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Bibliographic Details
Published in:	Designed monomers and polymers Vol. 27; no. 1; pp. 1 - 9
Main Authors:	Yan, Zichun, Brown, D Andrew, Alpi, Trey, Nagatomi, Jiro, Mefford, O Thompson
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 2024
Subjects:	hydrogel phase change poly ethylene oxide poly propylene oxide polymer thermoresponsive poly propylene oxide polymer phase change poly ethylene oxide hydrogel Thermoresponsive
Online Access:	Get full text
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Summary:	The thermoresponsive properties of poloxamine (tetra-branch PEO-PPO block copolymer) hydrogels are related to several variables. Of particular interest to this study were the molecular weight of the polymer, the molar ratio between PEO and PPO blocks, and the concentration of the aqueous solution. Accurately controlling the thermoresponsive behaviors of the polymer is critical to the application of such materials; therefore, the structure-property relationship of tetra-branch PEO-PPO block copolymer was studied by synthesis via anionic ring-opening polymerization (AROP). The structure-property relationships were studied by measuring the thermoresponsive behavior via differential scanning calorimetry (DSC) and developing an empirical model which statistically fit the collected data. This empirical model was then used for designing poloxamines that have critical micellization temperatures (CMT) between room temperature and physiological temperature. The model was validated with three polymers that targeted a CMT of 308 K (35°C). The empirical model showed great success in guiding the synthesis of poloxamines showing a temperature difference of less than 3 K between the predicted and the observed CMTs. This study showed a great potential of using an empirical model to set synthesis parameters to control the properties of the polymer products.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1385-772X 1568-5551 1568-5551
DOI:	10.1080/15685551.2024.2313268