Search Results - "Alpert, Ayelet"

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring by Alpert, Ayelet, Pickman, Yishai, Leipold, Michael, Rosenberg-Hasson, Yael, Ji, Xuhuai, Gaujoux, Renaud, Rabani, Hadas, Starosvetsky, Elina, Kveler, Ksenya, Schaffert, Steven, Furman, David, Caspi, Oren, Rosenschein, Uri, Khatri, Purvesh, Dekker, Cornelia L., Maecker, Holden T., Davis, Mark M., Shen-Orr, Shai S.

“…Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering…”
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Reconstructing disease dynamics for mechanistic insights and clinical benefit by Frishberg, Amit, Milman, Neta, Alpert, Ayelet, Spitzer, Hannah, Asani, Ben, Schiefelbein, Johannes B., Bakin, Evgeny, Regev-Berman, Karen, Priglinger, Siegfried G., Schultze, Joachim L., Theis, Fabian J., Shen-Orr, Shai S.

“…Diseases change over time, both phenotypically and in their underlying molecular processes. Though understanding disease progression dynamics is critical for…”
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TIM-3 Genetic Variants Are Associated with Altered Clinical Outcome and Susceptibility to Gram-Positive Infections in Patients with Sepsis by Mewes, Caspar, Alexander, Tessa, Büttner, Benedikt, Hinz, José, Alpert, Ayelet, Popov, Aron-F, Ghadimi, Michael, Beißbarth, Tim, Tzvetkov, Mladen, Grade, Marian, Quintel, Michael, Bergmann, Ingo, Mansur, Ashham

“…: Previous studies have reported the fundamental role of immunoregulatory proteins in the clinical phenotype and outcome of sepsis. This study investigated two…”
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Alignment of single-cell trajectories to compare cellular expression dynamics by Alpert, Ayelet, Moore, Lindsay S, Dubovik, Tania, Shen-Orr, Shai S

“…cellAlign enables quantitative comparisons of expression dynamics within and between single-cell trajectories based on single-cell RNA-seq or mass cytometry…”
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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging by Sayed, Nazish, Huang, Yingxiang, Nguyen, Khiem, Krejciova-Rajaniemi, Zuzana, Grawe, Anissa P, Gao, Tianxiang, Tibshirani, Robert, Hastie, Trevor, Alpert, Ayelet, Cui, Lu, Kuznetsova, Tatiana, Rosenberg-Hasson, Yael, Ostan, Rita, Monti, Daniela, Lehallier, Benoit, Shen-Orr, Shai S, Maecker, Holden T, Dekker, Cornelia L, Wyss-Coray, Tony, Franceschi, Claudio, Jojic, Vladimir, Haddad, François, Montoya, José G, Wu, Joseph C, Davis, Mark M, Furman, David

“…While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From…”
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Interactions between immune cell types facilitate the evolution of immune traits by Dubovik, Tania, Lukačišin, Martin, Starosvetsky, Elina, LeRoy, Benjamin, Normand, Rachelly, Admon, Yasmin, Alpert, Ayelet, Ofran, Yishai, G’Sell, Max, Shen-Orr, Shai S.

“…An essential prerequisite for evolution by natural selection is variation among individuals in traits that affect fitness 1 . The ability of a system to…”
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UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems by Malcov-Brog, Hagar, Alpert, Ayelet, Golan, Tamar, Parikh, Shivang, Nordlinger, Alice, Netti, Francesca, Sheinboim, Danna, Dror, Iris, Thomas, Laetitia, Cosson, Camille, Gonen, Pinchas, Stanevsky, Yury, Brenner, Ronen, Perluk, Tomer, Frand, Jacob, Elgavish, Sharona, Nevo, Yuval, Rahat, Dolev, Tabach, Yuval, Khaled, Mehdi, Shen-Orr, Shai S., Levy, Carmit

“…Skin sun exposure induces two protection programs: stress responses and pigmentation, the former within minutes and the latter only hours afterward. Although…”
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The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis by Mewes, Caspar, Büttner, Benedikt, Hinz, José, Alpert, Ayelet, Popov, Aron Frederik, Ghadimi, Michael, Beissbarth, Tim, Tzvetkov, Mladen, Shen-Orr, Shai, Bergmann, Ingo, Mansur, Ashham

“…Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a surface protein on T cells, that has an inhibitory effect on the host immune reaction and prevents…”
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Alignment of single-cell trajectories by tuMap enables high-resolution quantitative comparison of cancer samples by Alpert, Ayelet, Nahman, Ornit, Starosvetsky, Elina, Hayun, Michal, Curiel, Tyler J, Ofran, Yishai, Shen-Orr, Shai S

“…Single-cell technologies allow characterization of cancer samples as continuous developmental trajectories. Yet, the obtained temporal resolution cannot be…”
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A personalized network framework reveals predictive axis of anti-TNF response across diseases by Gerassy-Vainberg, Shiran, Starosvetsky, Elina, Gaujoux, Renaud, Blatt, Alexandra, Maimon, Naama, Gorelik, Yuri, Pressman, Sigal, Alpert, Ayelet, Bar-Yoseph, Haggai, Dubovik, Tania, Perets, Benny, Katz, Adir, Milman, Neta, Segev, Meital, Chowers, Yehuda, Shen-Orr, Shai S

“…Personalized treatment of complex diseases has been mostly predicated on biomarker identification of one drug-disease combination at a time. Here, we use a…”
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Effect of the Lymphocyte Activation Gene 3 Polymorphism rs951818 on Mortality and Disease Progression in Patients with Sepsis—A Prospective Genetic Association Study by Mewes, Caspar, Alexander, Tessa, Büttner, Benedikt, Hinz, José, Alpert, Ayelet, Popov, Aron-F., Beißbarth, Tim, Tzvetkov, Mladen, Grade, Marian, Quintel, Michael, Bergmann, Ingo, Mansur, Ashham

“…(1) Background: Sepsis is a leading cause of death and a global public health problem. Accordingly, deciphering the underlying molecular mechanisms of this…”
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CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis by Mewes, Caspar, Büttner, Benedikt, Hinz, José, Alpert, Ayelet, Popov, Aron-Frederik, Ghadimi, Michael, Beissbarth, Tim, Tzvetkov, Mladen, Jensen, Ole, Runzheimer, Julius, Quintel, Michael, Shen-Orr, Shai, Bergmann, Ingo, Mansur, Ashham

“…Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a coinhibitory checkpoint protein expressed on the surface of T cells. A recent study by our working…”
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Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging by Sayed, Nazish, Huang, Yingxiang, Nguyen, Khiem, Krejciova-Rajaniemi, Zuzana, Grawe, Anissa P, Gao, Tianxiang, Tibshirani, Robert, Hastie, Trevor, Alpert, Ayelet, Cui, Lu, Kuznetsova, Tatiana, Rosenberg-Hasson, Yael, Ostan, Rita, Monti, Daniela, Lehallier, Benoit, Shen-Orr, Shai S, Maecker, Holden T, Dekker, Cornelia L, Wyss-Coray, Tony, Franceschi, Claudio, Jojic, Vladimir, Haddad, François, Montoya, José G, Wu, Joseph C, Davis, Mark M, Furman, David

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Abstract 15235: Circulating Immune Profile of Aging, a Translational Study on the Role of Growth Differentiation Factor-15 and Monokine Induced by Interferon gamma by Arthur, Jennifer A, Bouajila, Sara, Amsallem, Myriam, Shen Orr, Shai, Kobayashi, Yukari, Rosenberg-Hasson, Yael, Alpert, Ayelet, Moneghetti, Kegan J, Dekker, Cornelia, Contrepois, Kevin, Martin, Beth A, Kouznetsova, Tatiana, Davis, Mark, Karakikes, Ioannis, Maecker, Holden T, Haddad, Francois

“…IntroductionWhile inflammation is frequently found in elderly individuals, it remains controversial whether healthy aging is associated with an increase in…”
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