Search Results - "Alper, S"

Applications, challenges, and needs for employing synthetic biology beyond the lab by Brooks, Sierra M., Alper, Hal S.

“…Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’…”
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The development and characterization of synthetic minimal yeast promoters by Redden, Heidi, Alper, Hal S.

“…Synthetic promoters, especially minimally sized, are critical for advancing fungal synthetic biology. Fungal promoters often span hundreds of base pairs,…”
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Bio-synthesis of food additives and colorants-a growing trend in future food by Sun, Lichao, Xin, Fengjiao, Alper, Hal S.

“…Food additives and colorants are extensively used in the food industry to improve food quality and safety during processing, storage and packing. Sourcing of…”
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Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances by Wagner, James M., Alper, Hal S.

“…•Non-conventional yeasts are attractive hosts for biotechnology.•Synthetic biology and traditional molecular genetic techniques are advancing these…”
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Machine learning-aided engineering of hydrolases for PET depolymerization by Lu, Hongyuan, Diaz, Daniel J., Czarnecki, Natalie J., Zhu, Congzhi, Kim, Wantae, Shroff, Raghav, Acosta, Daniel J., Alexander, Bradley R., Cole, Hannah O., Zhang, Yan, Lynd, Nathaniel A., Ellington, Andrew D., Alper, Hal S.

“…Plastic waste poses an ecological challenge 1 – 3 and enzymatic degradation offers one, potentially green and scalable, route for polyesters waste recycling 4…”
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Promoter engineering: Recent advances in controlling transcription at the most fundamental level by Blazeck, John, Alper, Hal S.

“…Synthetic control of gene expression is critical for metabolic engineering efforts. Specifically, precise control of key pathway enzymes (heterologous or…”
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Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production by Blazeck, John, Hill, Andrew, Liu, Leqian, Knight, Rebecca, Miller, Jarrett, Pan, Anny, Otoupal, Peter, Alper, Hal S.

“…Economic feasibility of biosynthetic fuel and chemical production hinges upon harnessing metabolism to achieve high titre and yield. Here we report a thorough…”
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Metabolic engineering of microbial cell factories for production of nutraceuticals by Yuan, Shuo-Fu, Alper, Hal S

“…Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules,…”
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Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction by Alper, S L

“…Mutations in the genes encoding the mechanosensitive cation channels PIEZO1 and PIEZO2 are responsible for multiple hereditary human diseases. Loss-of-function…”
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The GRADE Working Group clarifies the construct of certainty of evidence by Hultcrantz, Monica, Rind, David, Akl, Elie A, Treweek, Shaun, Mustafa, Reem A, Iorio, Alfonso, Alper, Brian S, Meerpohl, Joerg J, Murad, M Hassan, Ansari, Mohammed T, Katikireddi, Srinivasa Vittal, Östlund, Pernilla, Tranæus, Sofia, Christensen, Robin, Gartlehner, Gerald, Brozek, Jan, Izcovich, Ariel, Schünemann, Holger, Guyatt, Gordon

“…Abstract Objective To clarify the GRADE (grading of recommendations assessment, development and evaluation) definition of certainty of evidence and suggest…”
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Enabling tools for high-throughput detection of metabolites: Metabolic engineering and directed evolution applications by Lin, Jyun-Liang, Wagner, James M., Alper, Hal S.

“…Within the Design-Build-Test Cycle for strain engineering, rapid product detection and selection strategies remain challenging and limit overall throughput…”
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Compartmentalized microbes and co-cultures in hydrogels for on-demand bioproduction and preservation by Johnston, Trevor G., Yuan, Shuo-Fu, Wagner, James M., Yi, Xiunan, Saha, Abhijit, Smith, Patrick, Nelson, Alshakim, Alper, Hal S.

“…Most mono- and co-culture bioprocess applications rely on large-scale suspension fermentation technologies that are not easily portable, reusable, or suitable…”
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Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces by Liu, Leqian, Redden, Heidi, Alper, Hal S

“…Graphical abstract…”
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An evolutionary metabolic engineering approach for enhancing lipogenesis in Yarrowia lipolytica by Liu, Leqian, Pan, Anny, Spofford, Caitlin, Zhou, Nijia, Alper, Hal S.

“…Lipogenic organisms provide an ideal platform for biodiesel and oleochemical production. Through our previous rational metabolic engineering efforts,…”
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De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture by Yuan, Shuo-Fu, Yi, Xiunan, Johnston, Trevor G, Alper, Hal S

“…Resveratrol is a plant secondary metabolite with diverse, potential health-promoting benefits. Due to its nutraceutical merit, bioproduction of resveratrol via…”
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In vivo continuous evolution of genes and pathways in yeast by Crook, Nathan, Abatemarco, Joseph, Sun, Jie, Wagner, James M., Schmitz, Alexander, Alper, Hal S.

“…Directed evolution remains a powerful, highly generalizable approach for improving the performance of biological systems. However, implementations in…”
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RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes by Abatemarco, Joseph, Sarhan, Maen F., Wagner, James M., Lin, Jyun-Liang, Liu, Leqian, Hassouneh, Wafa, Yuan, Shuo-Fu, Alper, Hal S., Abate, Adam R.

“…Synthetic biology and metabolic engineering seek to re-engineer microbes into “living foundries” for the production of high value chemicals. Through a…”
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Rewiring yeast sugar transporter preference through modifying a conserved protein motif by Young, Eric M., Tong, Alice, Bui, Hang, Spofford, Caitlin, Alper, Hal S.

“…Utilization of exogenous sugars found in lignocellulosic biomass hydrolysates, such as xylose, must be improved before yeast can serve as an efficient biofuel…”
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Directed Evolution of Xylose Isomerase for Improved Xylose Catabolism and Fermentation in the Yeast Saccharomyces cerevisiae by LEE, Sun-Mi, JELLISON, Taylor, ALPER, Hal S

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The synthetic biology toolbox for tuning gene expression in yeast by Redden, Heidi, Morse, Nicholas, Alper, Hal S.

“…Saccharomyces cerevisiae can serve as a key production platform for biofuels, nutraceuticals, industrial compounds, and therapeutic proteins. Over the recent…”
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