Search Results - "Alpay, S. Neslihan"

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells by Ashour, Ahmed A., Abdel-Aziz, Abdel-Aziz H., Mansour, Ahmed M., Alpay, S. Neslihan, Huo, Longfei, Ozpolat, Bulent

“…Pancreatic cancer (PaCa) is one of the most aggressive, apoptosis-resistant and currently incurable cancers with a poor survival rate. Eukaryotic elongation…”
Get full text

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer by Tekedereli, Ibrahim, Alpay, S Neslihan, Tavares, Clint D J, Cobanoglu, Zehra E, Kaoud, Tamer S, Sahin, Ibrahim, Sood, Anil K, Lopez-Berestein, Gabriel, Dalby, Kevin N, Ozpolat, Bulent

“…Eukaryotic elongation factor 2 kinase (eEF-2K), through its phosphorylation of elongation factor 2 (eEF2), provides a mechanism by which cells can control the…”
Get full text

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells by Gurbuz, Nilgun, Ashour, Ahmed A, Alpay, S Neslihan, Ozpolat, Bulent

“…Pancreatic ductal adenocarcinoma is characterized by extensive local tumor invasion, metastasis and early systemic dissemination. The vast majority of…”
Get full text

Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (−) and ER (+) Breast Cancer by Tekedereli, Ibrahim, Alpay, S Neslihan, Akar, Ugur, Yuca, Erkan, Ayugo-Rodriguez, Cristian, Han, He-Dong, Sood, Anil K, Lopez-Berestein, Gabriel, Ozpolat, Bulent

“…Bcl-2 is overexpressed in about a half of human cancers and 50–70% of breast cancer patients, thereby conferring resistance to conventional therapies and…”
Get full text

Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells by Gurbuz, Nilgun, Ashour, Ahmed A, Alpay, S Neslihan, Ozpolat, Bulent

“…Pancreatic ductal adenocarcinoma is characterized by extensive local tumor invasion, metastasis and early systemic dissemination. The vast majority of…”
Get full text

Erythropoietin Stimulates Tumor Growth via EphB4 by Pradeep, Sunila, Huang, Jie, Mora, Edna M., Nick, Alpa M., Cho, Min Soon, Wu, Sherry Y., Noh, Kyunghee, Pecot, Chad V., Rupaimoole, Rajesha, Stein, Martin A., Brock, Stephan, Wen, Yunfei, Xiong, Chiyi, Gharpure, Kshipra, Hansen, Jean M., Nagaraja, Archana S., Previs, Rebecca A., Vivas-Mejia, Pablo, Han, Hee Dong, Hu, Wei, Mangala, Lingegowda S., Zand, Behrouz, Stagg, Loren J., Ladbury, John E., Ozpolat, Bulent, Alpay, S. Neslihan, Nishimura, Masato, Stone, Rebecca L., Matsuo, Koji, Armaiz-Peña, Guillermo N., Dalton, Heather J., Danes, Christopher, Goodman, Blake, Rodriguez-Aguayo, Cristian, Kruger, Carola, Schneider, Armin, Haghpeykar, Shyon, Jaladurgam, Padmavathi, Hung, Mien-Chie, Coleman, Robert L., Liu, Jinsong, Li, Chun, Urbauer, Diana, Lopez-Berestein, Gabriel, Jackson, David B., Sood, Anil K.

“…While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival…”
Get full text

Re: Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome by Oktay, Ahmet Afsin, Alpay, S Neslihan, Sahin, Ibrahim Halil

Get full text

PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells by Ozpolat, Bulent, Akar, Ugur, Tekedereli, Ibrahim, Alpay, S. Neslihan, Barria, Magaly, Gezgen, Baki, Zhang, Nianxiang, Coombes, Kevin, Kornblau, Steve, Lopez-Berestein, Gabriel

“…Translation initiation and activity of eukaryotic initiation factor-alpha (eIF2α), the rate-limiting step of translation initiation, is often overactivated in…”
Get full text

PKC [delta]Regulates Translation Initiation through PKR and eIF2 [alpha]in Response to Retinoic Acid in Acute Myeloid Leukemia Cells by Ozpolat, Bulent, Akar, Ugur, Ibrahim Tekedereli, Alpay, S Neslihan, Barria, Magaly, Gezgen, Baki, Zhang, Nianxiang, Coombes, Kevin, Kornblau, Steve, Lopez-Berestein, Gabriel

“…Translation initiation and activity of eukaryotic initiation factor-alpha (eIF2 α), the rate-limiting step of translation initiation, is often overactivated in…”
Get full text