Search Results - "Alossaimi, Manal A"

A Novel Quantum Dots-Based Fluorescent Sensor for Determination of the Anticancer Dacomitinib: Application to Dosage Forms by Alossaimi, Manal A, Elmansi, Heba, Alajaji, Mai, Altharawi, Ali, Altamimi, Abdulmalik S A, Magdy, Galal

“…One of the most promising drugs recently approved for the treatment of various types of cancer is dacomitinib, which belongs to the tyrosine kinase inhibitor…”
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Exploring Nanocarriers as Treatment Modalities for Skin Cancer by Adnan, Mohammad, Akhter, Md Habban, Afzal, Obaid, Altamimi, Abdulmalik S A, Ahmad, Irfan, Alossaimi, Manal A, Jaremko, Mariusz, Emwas, Abdul-Hamid, Haider, Tanweer, Haider, Md Faheem

“…Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental…”
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Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics by Alamri, Mubarak A., Altharawi, Ali, Alabbas, Alhumaidi B., Alossaimi, Manal A., Alqahtani, Safar M.

“…Coronavirus disease 2019 (COVID-19) has affected almost every country in the world by causing a global pandemic with a high mortality rate. Lack of an…”
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Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer by Sarma, Kangkan, Akther, Md Habban, Ahmad, Irfan, Afzal, Obaid, Altamimi, Abdulmalik S A, Alossaimi, Manal A, Jaremko, Mariusz, Emwas, Abdul-Hamid, Gautam, Preety

“…Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the…”
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An integrated computational approach towards novel drugs discovery against polyketide synthase 13 thioesterase domain of Mycobacterium tuberculosis by Altharawi, Ali, Alossaimi, Manal A., Alanazi, Mohammed M., Alqahatani, Safar M., Tahir ul Qamar, Muhammad

“…The acquired drug resistance by Mycobacterium tuberculosis (M. tuberculosis) to antibiotics urges the need for developing novel anti- M. tuberculosis drugs…”
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Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agents by Soliman, Amal F., Elimam, Diaaeldin M., El-Senduny, Fardous F., Alossaimi, Manal A., Alamri, Mubarak, Abdel Bar, Fatma M.

“…The major labdanes in the oleogum resin of Araucaria heterophylla (Salisb.) Franco, 13-epi-cupressic acid (1) and acetyl-13-epi-cupressic acid (2) were used to…”
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In Vitro and In Silico Investigation of Polyacetylenes from Launaea capitata (Spreng.) Dandy as Potential COX-2, 5-LOX, and BchE Inhibitors by Abdel Bar, Fatma M, Mira, Amira, Foudah, Ahmed I, Alossaimi, Manal A, Alkanhal, Shatha F, Aldaej, Alanoud M, ElNaggar, Mai H

“…Diverse secondary metabolites are biosynthesized by plants via various enzymatic cascades. These have the capacity to interact with various human receptors,…”
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Novel 2-Sulfanylquinazolin-4(3 H )-one Derivatives as Multi-Kinase Inhibitors and Apoptosis Inducers: A Synthesis, Biological Evaluation, and Molecular Docking Study by Altharawi, Ali, Alanazi, Mohammed M, Alossaimi, Manal A, Alanazi, Ashwag S, Alqahtani, Safar M, Geesi, Mohammed H, Riadi, Yassine

“…The discovery of multi-targeted kinase inhibitors emerged as a potential strategy in the therapy of multi-genic diseases, such as cancer, that cannot be…”
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Anti-Quorum Sensing and Anti-Biofilm Activity of Pelargonium × hortorum Root Extract against Pseudomonas aeruginosa : Combinatorial Effect of Catechin and Gallic Acid by Abdel Bar, Fatma M, Alossaimi, Manal A, Elekhnawy, Engy, Alzeer, May Abdullah Abulrahman, Abo Kamer, Amal, Moglad, Ehssan, ElNaggar, Mai H

“…HPLC-UV was used to compare the major constituents of two cultivars and root extract. It revealed the presence of catechin and gallic acid in high…”
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Molecular and Structural Analysis of Specific Mutations from Saudi Isolates of SARS-CoV-2 RNA-Dependent RNA Polymerase and their Implications on Protein Structure and Drug-Protein Binding by Alamri, Mubarak A, Tahir Ul Qamar, Muhammad, Alabbas, Alhumaidi B, Alqahtani, Safar M, Alossaimi, Manal A, Azam, Sikandar, Hashmi, Muhammad Harris, Rajoka, Muhammad Shahid Riaz

“…The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has stressed the global health system to a significant level,…”
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Synthesis, Anticancer Activity, and In Silico Studies of 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine Analogs by Ahsan, Mohamed Jawed, Gautam, Krishna, Ali, Amena, Ali, Abuzer, Altamimi, Abdulmalik Saleh Alfawaz, Salahuddin, Alossaimi, Manal A., Lakshmi, S. V. V. N. S. M., Ahsan, Md. Faiyaz

“…In the current study, we described the synthesis of ten new 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine analogs (4a–j), as well as their…”
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Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies by Afzal, Obaid, Ali, Amena, Ali, Abuzer, Altamimi, Abdulmalik Saleh Alfawaz, Alossaimi, Manal A., Bakht, Md Afroz, Salahuddin, Alamri, Mubarak A., Ahsan, Md. Faiyaz, Ahsan, Mohamed Jawed

“…We report herein the synthesis, docking studies and biological evaluation of a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues…”
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Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate by Zaki, Randa Mohammed, Alfadhel, Munerah M, Alossaimi, Manal A, Elsawaf, Lara Ayman, Devanathadesikan Seshadri, Vidya, Almurshedi, Alanood S, Yusif, Rehab Mohammad, Said, Mayada

“…This study aimed to formulate and statistically optimize glycerosomal formulations of Quetiapine fumarate (QTF) to increase its oral bioavailability and…”
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Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study by Shahroz, Mir Mohammad, Sharma, Hemant Kumar, Altamimi, Abdulmalik S A, Alamri, Mubarak A, Ali, Abuzer, Ali, Amena, Alqahtani, Safar, Altharawi, Ali, Alabbas, Alhumaidi B, Alossaimi, Manal A, Riadi, Yassine, Firoz, Ahmad, Afzal, Obaid

“…The dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a novel, promising and emerging biological target for therapeutic intervention in…”
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System biology approach to identify the novel biomarkers in glioblastoma multiforme tumors by using computational analysis by Alqahtani, Safar M, Altharawi, Ali, Alabbas, Alhumaidi, Ahmad, Faisal, Ayaz, Hassan, Nawaz, Asia, Rahman, Sidra, Alossaimi, Manal A

“…The most common primary brain tumor in adults is glioblastoma multiforme (GBM), accounting for 45.2% of all cases. The characteristics of GBM, a highly…”
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Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies by Altamimi, Abdulmalik S., El-Azab, Adel S., Abdelhamid, Sami G., Alamri, Mubarak A., Bayoumi, Ashraf H., Alqahtani, Safar M., Alabbas, Alhumaidi B., Altharawi, Ali I., Alossaimi, Manal A., Mohamed, Menshawy A.

“…A new series of 8-methoxy-2-trimethoxyphenyl-3-substituted quinazoline-4(3)-one compounds were designed, synthesized, and screened for antitumor activity…”
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Determination of α1-acid glycoprotein (AGP) concentration by HPLC in patients following local infiltration analgesia for primary total hip arthroplasty and its relation to ropivacaine (total and unbound) by Abbas, Muhammad, Alossaimi, Manal A, Altamimi, Abdulmalik S A, Alajaji, Mai, Watson, David G, Shah, Sayyed I, Shah, Yasar, Anwar, Mohammad S

“…This study was performed to determine the levels of α1-acid glycoprotein (AGP) in old-age patients undergoing total hip arthroplasty. AGP is considered an…”
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Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents by Alossaimi, Manal A., Riadi, Yassine, Alnuwaybit, Ghaida N., Md, Shadab, Alkreathy, Huda Mohammed, Elekhnawy, Engy, Geesi, Mohammed H., Alqahtani, Safar M., Afzal, Obaid

“…[Display omitted] •Quinazolinone derivatives were designed keeping Ispinesib and Idelalisib as reference structures.•Compounds 3a, 3b, 3e, 3g and 3h revealed…”
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Pelargonium sidoides Root Extract: Simultaneous HPLC Separation, Determination, and Validation of Selected Biomolecules and Evaluation of SARS-CoV-2 Inhibitory Activity by Alossaimi, Manal A., Alzeer, May A., Abdel Bar, Fatma M., ElNaggar, Mai H.

“…This study aimed to establish a validated HPLC-UV analytical method for the determination of gallic acid, catechin, scopoletin, and umckalin in…”
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Aspartames Alter Pharmacokinetics Parameters of Erlotinib and Gefitinib and Elevate Liver Enzymes in Wistar Rats by AlRasheed, Hajer, Almomen, Aliyah, Aljohar, Haya I, Arafah, Maria, Almotawa, Rana Y, Alossaimi, Manal A, Alzoman, Nourah Z

“…Background: Erlotinib (ERL) and gefitinib (GEF) are extensively metabolized by CYP450 enzymes. Aspartame (ASP), an artificial sweetener, induces CYP2E1 and…”
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