Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital

Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital

Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal surv...

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Bibliographic Details
Published in:Parasitology research (1987) Vol. 113; no. 5; pp. 1897 - 1907
Main Authors: Rezende, Fábio, Alonso, Marcela A, Souza, Carina M, Thyssen, Patrícia J, Linhares, Arício X
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-05-2014
Springer Berlin Heidelberg
Springer
Subjects:
adults
Animals
Anticonvulsants - pharmacology
Biomedical and Life Sciences
Biomedicine
Blowflies
Calliphoridae
Central Nervous System Stimulants - pharmacology
Chrysomya
Chrysomya albiceps
Chrysomya megacephala
Chrysomya putoria
Diptera
Diptera - drug effects
Diptera - growth & development
Dosage and administration
Drug interactions
Health aspects
humidity
immatures
Immunology
Larva - drug effects
Larva - growth & development
Medical Microbiology
Methylphenidate
Methylphenidate - pharmacology
Methylphenidate hydrochloride
Microbiology
Original Paper
Pharmaceutical research
Phenobarbital
Phenobarbital - pharmacology
Photoperiod
Pupa - drug effects
pupariation
survival rate
Temperature
Time Factors
Zoological research
Brazil
Blowflies
Entomotoxicology
Larval growth
Postmortem interval
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Summary:Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD–methylphenidate hydrochloride plus 1× TD–phenobarbital, 50× TD–methylphenidate hydrochloride plus 3.3× TD–phenobarbital, and 100× TD–methylphenidate hydrochloride plus 6.7× TD–phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10 %), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways.
Bibliography:http://dx.doi.org/10.1007/s00436-014-3837-5
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-014-3837-5