Search Results - "Alonso, Direna"

Arid1a restrains Kras-dependent changes in acinar cell identity by Livshits, Geulah, Alonso-Curbelo, Direna, Morris, 4th, John P, Koche, Richard, Saborowski, Michael, Wilkinson, John Erby, Lowe, Scott W

“…Mutations in members of the SWI/SNF chromatin remodeling family are common events in cancer, but the mechanisms whereby disruption of SWI/SNF components alters…”
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Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics by Olmeda, David, Cerezo‐Wallis, Daniela, Mucientes, Cynthia, Calvo, Tonantzin G, Cañón, Estela, Alonso‐Curbelo, Direna, Ibarz, Nuria, Muñoz, Javier, Rodriguez‐Peralto, José L, Ortiz‐Romero, Pablo, Ortega, Sagrario, Soengas, María S

“…Long‐range communication between tumor cells and the lymphatic vasculature defines competency for metastasis in different cancer types, particularly in…”
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BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance by Tasdemir, Nilgun, Banito, Ana, Roe, Jae-Seok, Alonso-Curbelo, Direna, Camiolo, Matthew, Tschaharganeh, Darjus F, Huang, Chun-Hao, Aksoy, Ozlem, Bolden, Jessica E, Chen, Chi-Chao, Fennell, Myles, Thapar, Vishal, Chicas, Agustin, Vakoc, Christopher R, Lowe, Scott W

“…Oncogene-induced senescence is a potent barrier to tumorigenesis that limits cellular expansion following certain oncogenic events. Senescent cells display a…”
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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer by Escobar-Hoyos, Luisa F., Penson, Alex, Kannan, Ram, Cho, Hana, Pan, Chun-Hao, Singh, Rohit K., Apken, Lisa H., Hobbs, G. Aaron, Luo, Renhe, Lecomte, Nicolas, Babu, Sruthi, Pan, Fong Cheng, Alonso-Curbelo, Direna, Morris, John P., Askan, Gokce, Grbovic-Huezo, Olivera, Ogrodowski, Paul, Bermeo, Jonathan, Saglimbeni, Joseph, Cruz, Cristian D., Ho, Yu-Jui, Lawrence, Sharon A., Melchor, Jerry P., Goda, Grant A., Bai, Karen, Pastore, Alessandro, Hogg, Simon J., Raghavan, Srivatsan, Bailey, Peter, Chang, David K., Biankin, Andrew, Shroyer, Kenneth R., Wolpin, Brian M., Aguirre, Andrew J., Ventura, Andrea, Taylor, Barry, Der, Channing J., Dominguez, Daniel, Kümmel, Daniel, Oeckinghaus, Andrea, Lowe, Scott W., Bradley, Robert K., Abdel-Wahab, Omar, Leach, Steven D.

“…Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is…”
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p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors by Karras, Panagiotis, Riveiro-Falkenbach, Erica, Cañón, Estela, Tejedo, Cristina, Calvo, Tonantzin G., Martínez-Herranz, Raúl, Alonso-Curbelo, Direna, Cifdaloz, Metehan, Perez-Guijarro, Eva, Gómez-López, Gonzalo, Ximenez-Embun, Pilar, Muñoz, Javier, Megias, Diego, Olmeda, David, Moscat, Jorge, Ortiz-Romero, Pablo L., Rodríguez-Peralto, Jose L., Soengas, María S.

“…Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of…”
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Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity by Finley, Lydia W. S., Vardhana, Santosha A., Carey, Bryce W., Alonso-Curbelo, Direna, Koche, Richard, Chen, Yanyang, Wen, Duancheng, King, Bryan, Radler, Megan R., Rafii, Shahin, Lowe, Scott W., Allis, C. David, Thompson, Craig B.

“…A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4…”
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Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control by Kozuka, Chisayo, Efthymiou, Vissarion, Sales, Vicencia M, Zhou, Liyuan, Osataphan, Soravis, Yuchi, Yixing, Chimene-Weiss, Jeremy, Mulla, Christopher, Isganaitis, Elvira, Desmond, Jessica, Sanechika, Suzuka, Kusuyama, Joji, Goodyear, Laurie, Shi, Xu, Gerszten, Robert E, Aguayo-Mazzucato, Cristina, Carapeto, Priscila, Teixeira, Silvania DaSilva, Sandoval, Darleen, Alonso-Curbelo, Direna, Wu, Lei, Qi, Jun, Patti, Mary-Elizabeth

“…Epigenetic regulation is an important factor in glucose metabolism, but underlying mechanisms remain largely unknown. Here we investigated epigenetic control…”
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Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers by Osmanbeyoglu, Hatice U., Shimizu, Fumiko, Rynne-Vidal, Angela, Alonso-Curbelo, Direna, Chen, Hsuan-An, Wen, Hannah Y., Yeung, Tsz-Lun, Jelinic, Petar, Razavi, Pedram, Lowe, Scott W., Mok, Samuel C., Chiosis, Gabriela, Levine, Douglas A., Leslie, Christina S.

“…Chromatin accessibility data can elucidate the developmental origin of cancer cells and reveal the enhancer landscape of key oncogenic transcriptional…”
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Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers by Pérez-Guijarro, Eva, Karras, Panagiotis, Cifdaloz, Metehan, Martínez-Herranz, Raúl, Cañón, Estela, Graña, Osvaldo, Horcajada-Reales, Celia, Alonso-Curbelo, Direna, Calvo, Tonantzin G., Gómez-López, Gonzalo, Bellora, Nicolas, Riveiro-Falkenbach, Erica, Ortiz-Romero, Pablo L., Rodríguez-Peralto, José L., Maestre, Lorena, Roncador, Giovanna, de Agustín Asensio, Juan C., Goding, Colin R., Eyras, Eduardo, Megías, Diego, Méndez, Raúl, Soengas, María S.

“…Nuclear 3’-end-polyadenylation is essential for the transport, stability and translation of virtually all eukaryotic mRNAs. Poly(A) tail extension can also…”
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Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells by Tormo, Damià, Chęcińska, Agnieszka, Alonso-Curbelo, Direna, Pérez-Guijarro, Eva, Cañón, Estela, Riveiro-Falkenbach, Erica, Calvo, Tonantzin G., Larribere, Lionel, Megías, Diego, Mulero, Francisca, Piris, Miguel A., Dash, Rupesh, Barral, Paola M., Rodríguez-Peralto, José L., Ortiz-Romero, Pablo, Tüting, Thomas, Fisher, Paul B., Soengas, María S.

“…Inappropriate drug delivery, secondary toxicities, and persistent chemo- and immunoresistance have traditionally compromised treatment response in melanoma…”
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Self-killing of melanoma cells by cytosolic delivery of dsRNA: Wiring innate immunity for a coordinated mobilization of endosomes, autophagosomes and the apoptotic machinery in tumor cells by Alonso-Curbelo, Direna, Soengas, María S.

“…Patients with metastatic melanoma have a poor prognosis, primarily due to a generalized inefficacy of current anticancer treatments. Therefore, the…”
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Abstract C040: Investigating oncogene-inflammation cooperativity in pancreatic cancer by Woess, Katharina, Araguás, Sandra Blázquez, Diéguez, Andrea, Mateo, Lidia, Curbelo, Direna Alonso

“…Pancreatic ductal adenocarcinoma (PDAC) is generally diagnosed at advanced late stages when current treatments are usually ineffective. It is initiated from a…”
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Normal liver cells unlock cancer spread by Woess, Katharina, Alonso-Curbelo, Direna

“…Just like seeds landing on new soil, disseminated cancer cells (the 'seeds') reaching a distant organ (the 'soil') must adapt to their new environment, which…”
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Cancer spread in the liver is unlocked from within by Woess, Katharina, Alonso-Curbelo, Direna

“…How spreading tumour cells gain the ability to grow in organs away from where they originated is not fully understood. The discovery that normal liver cells…”
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Abstract A019: Neoplastic co-option of epithelial-immune interactions in pancreatic cancer by Alonso-Curbelo, Direna

“…Pancreatic ductal adenocarcinoma (PDAC) is initiated by a complex interplay between genetic and environmental insults that induce a marked remodeling of the…”
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Whole body imaging of lymphovascular niches identifies premetastatic roles of MIDKINE by Olmeda, David, Cerezo-Wallis, Daniela, Riveiro-Falkenbach, Erica, Pennacchi, Paula C., Contreras-Alcalde, Marta, Ibarz, Nuria, Cifdaloz, Metehan, Catena, Xavier, Calvo, Tonantzin G., Cañón, Estela, Alonso, Direna, Suarez, Javier, Osterloh, Lisa, Graña, Osvaldo, Mulero, Francisca, Megías, Diego, Cañamero, Marta, Martínez-Torrecuadrada, Jorge, Mondal, Chandrani, Di Martino, Julie, Lora, David, Martinez-Corral, Inés, Bravo-Cordero, J. Javier, Muñoz, Javier, Puig, Susana, Ortiz-Romero, Pablo, Rodriguez-Peralto, José L, Ortega, Sagrario, Soengas, María S.

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Senolytic CAR T cells reverse senescence-associated pathologies by Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W.

“…Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment 1 , 2 . Physiologically,…”
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A temporal perspective for tumor-associated macrophage identities and functions by Blériot, Camille, Dunsmore, Garett, Alonso-Curbelo, Direna, Ginhoux, Florent

“…Cancer is a progressive disease that can develop and evolve over decades, with inflammation playing a central role at each of its stages, from tumor initiation…”
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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer by Ruscetti, Marcus, Morris, John P., Mezzadra, Riccardo, Russell, James, Leibold, Josef, Romesser, Paul B., Simon, Janelle, Kulick, Amanda, Ho, Yu-jui, Fennell, Myles, Li, Jinyang, Norgard, Robert J., Wilkinson, John E., Alonso-Curbelo, Direna, Sridharan, Ramya, Heller, Daniel A., de Stanchina, Elisa, Stanger, Ben Z., Sherr, Charles J., Lowe, Scott W.

“…KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, immunosuppression, and…”
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A gene–environment-induced epigenetic program initiates tumorigenesis by Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L. V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.

“…Tissue damage increases the risk of cancer through poorly understood mechanisms 1 . In mouse models of pancreatic cancer, pancreatitis associated with tissue…”
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