Disorganization of anatomical connectivity in obsessive compulsive disorder: A multi-parameter diffusion tensor imaging study in a subpopulation of patients

Abstract Obsessive–compulsive disorder (OCD) is thought to involve large-scale brain systems but the anatomical connectivity via association fibers has not been specifically investigated yet. We evaluated organization and directionality of the major fiber bundles in a subpopulation of OCD, including...

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Published in:	Neurobiology of disease Vol. 37; no. 2; pp. 468 - 476
Main Authors:	Garibotto, V, Scifo, P, Gorini, A, Alonso, Clarke R, Brambati, S, Bellodi, L, Perani, D
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2010 Elsevier
Subjects:	Adult Anisotropy Brain - pathology Brain - physiopathology Brain Mapping Cohort Studies Connectivity Diffusion Diffusion Tensor Imaging Diffusion tensor imaging (DTI) Female Fiber tracts Functional Laterality Humans Male Nerve Fibers, Myelinated - pathology Nerve Net - pathology Nerve Net - physiopathology Neural Pathways - pathology Neural Pathways - physiopathology Neurology Neuropsychological Tests Obsessive compulsive disorder (OCD) Obsessive-Compulsive Disorder - pathology Obsessive-Compulsive Disorder - physiopathology Predictive Value of Tests Statistics as Topic Visuospatial functions White matter Young Adult Visuospatial functions Connectivity Fiber tracts Obsessive compulsive disorder (OCD) White matter Diffusion tensor imaging (DTI)
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Summary:	Abstract Obsessive–compulsive disorder (OCD) is thought to involve large-scale brain systems but the anatomical connectivity via association fibers has not been specifically investigated yet. We evaluated organization and directionality of the major fiber bundles in a subpopulation of OCD, including washers and checkers who presented decision making deficits, by measuring MRI parameters related to water self-diffusion (Fractional Anisotropy, FA) and fiber directionality (Principal Diffusion Direction, PDD) in 15 OCD and 16 control subjects. OCD patients showed significantly lower FA and altered PDD along the corpus callosum, cingulum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus bilaterally. The track-based analysis of the inferior fronto-occipital fasciculus confirmed a significant bilateral FA reduction. Lower FA values in the inferior fronto-occipital fasciculus, superior longitudinal fasciculus and corpus callosum correlated with symptom severity and neuropsychological performance. This multi-parameter MRI study revealed specific white matter abnormalities in OCD suggesting tract disorganization as main feature, reflected by local changes in fiber directionality. This altered anatomical connectivity might play a specific role in OCD pathophysiology.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0969-9961 1095-953X
DOI:	10.1016/j.nbd.2009.11.003