Search Results - "Alonge, Kimberly M."

Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes by Alonge, Kimberly M., D’Alessio, David A., Schwartz, Michael W.

“…Despite a rapidly growing literature, the role played by the brain in both normal glucose homeostasis and in type 2 diabetes pathogenesis remains poorly…”
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The "Loss" of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight? by Scarlett, Jarrad M, Hu, Shannon J, Alonge, Kimberly M

“…Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing extracellular matrix structures that assemble around neurons involved in…”
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Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4 by Alonge, Kimberly M., Meares, Gordon P., Hillgartner, F. Bradley

“…Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism…”
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Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism by Cyphert, Holly A, Alonge, Kimberly M, Ippagunta, Siri M, Hillgartner, F Bradley

“…Previous studies have shown that whole body deletion of the glucagon receptor suppresses the ability of starvation to increase hepatic fibroblast growth factor…”
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Neurocircuit regeneration by extracellular matrix reprogramming by Su, Shengzhang, Levasseur, Ian N, Alonge, Kimberly M

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Rapid Differentiation of Chondroitin Sulfate Isomers by Gas-phase Hydrogen-deuterium Exchange by Alonge, Kimberly M, Harkewicz, Rick, Guttman, Miklos

“…Chondroitin sulfate (CS)-glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides attached to CS proteoglycans that make up a major component…”
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Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission by Bentsen, Marie A., Rausch, Dylan M., Mirzadeh, Zaman, Muta, Kenjiro, Scarlett, Jarrad M., Brown, Jenny M., Herranz-Pérez, Vicente, Baquero, Arian F., Thompson, Jonatan, Alonge, Kimberly M., Faber, Chelsea L., Kaiyala, Karl J., Bennett, Camdin, Pyke, Charles, Ratner, Cecilia, Egerod, Kristoffer L., Holst, Birgitte, Meek, Thomas H., Kutlu, Burak, Zhang, Yu, Sparso, Thomas, Grove, Kevin L., Morton, Gregory J., Kornum, Birgitte R., García-Verdugo, José-Manuel, Secher, Anna, Jorgensen, Rasmus, Schwartz, Michael W., Pers, Tune H.

“…In rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of…”
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Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence by Kohnke, Sara, Buller, Sophie, Nuzzaci, Danae, Ridley, Katherine, Lam, Brian, Pivonkova, Helena, Bentsen, Marie A., Alonge, Kimberly M., Zhao, Chao, Tadross, John, Holmqvist, Staffan, Shimizu, Takahiro, Hathaway, Hannah, Li, Huiliang, Macklin, Wendy, Schwartz, Michael W., Richardson, William D., Yeo, Giles S.H., Franklin, Robin J.M., Karadottir, Ragnhildur T., Rowitch, David H., Blouet, Clemence

“…The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the…”
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Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity by Han, Chang Yeop, Kang, Inkyung, Harten, Ingrid A., Gebe, John A., Chan, Christina K., Omer, Mohamed, Alonge, Kimberly M., den Hartigh, Laura J., Gomes Kjerulf, Diego, Goodspeed, Leela, Subramanian, Savitha, Wang, Shari, Kim, Francis, Birk, David E., Wight, Thomas N., Chait, Alan

“…Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue…”
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Characterizing the human intestinal chondroitin sulfate glycosaminoglycan sulfation signature in inflammatory bowel disease by Francis, Kendra L., Zheng, Hengqi B., Suskind, David L., Murphree, Taylor A., Phan, Bao Anh, Quah, Emily, Hendrickson, Aarun S., Zhou, Xisheng, Nuding, Mason, Hudson, Alexandra S., Guttman, Miklos, Morton, Gregory J., Schwartz, Michael W., Alonge, Kimberly M., Scarlett, Jarrad M.

“…The intestinal extracellular matrix (ECM) helps maintain appropriate tissue barrier function and regulate host-microbial interactions. Chondroitin sulfate- and…”
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Assessing translational applicability of perineuronal net dysfunction in Alzheimer's disease across species by Hendrickson, Aarun S, Francis, Kendra L, Kumar, Asmit, Le, Jaden P, Scarlett, Jarrad M, Keene, C Dirk, Tovar, David A, Alonge, Kimberly M

“…In the context of aging and age-associated neurodegenerative disorders, the brain's extracellular matrix (ECM) serves as a critical regulator for neuronal…”
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Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma by Alonge, Kimberly M, Herbert, Melanie J, Yagi, Mayumi, Cook, David G, Banks, William A, Logsdon, Aric F

“…Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that enmesh and regulate neurocircuits involved in motor and sensory function. Maladaptive…”
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Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus by Mirzadeh, Zaman, Alonge, Kimberly M., Cabrales, Elaine, Herranz-Pérez, Vicente, Scarlett, Jarrad M., Brown, Jenny M., Hassouna, Rim, Matsen, Miles E., Nguyen, Hong T., Garcia-Verdugo, Jose Manuel, Zeltser, Lori M., Schwartz, Michael W.

“…In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC) 1 , a…”
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Distinct Roles for Brain and Pancreas in Basal and Postprandial Glucose Homeostasis by Alonge, Kimberly M, Porte, Daniel, Schwartz, Michael W

“…The glucose homeostasis system ensures that the circulating glucose level is maintained within narrow physiological limits both in the fasting (or basal) state…”
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Maternal Zika Virus Infection Alters Offspring Hippocampal Glycan Sulfation Patterns in Nonhuman Primates by Alonge, Kimberly M., Cervantes, Orlando, Francis, Kendra, Scarlett, Jarrad, Gale, Michael, Rajagopal, Lakshmi, Frevert, Charles, Adams Waldorf, Kristina, Schwartz, Michael

“…Zika virus (ZIKV) infection during pregnancy can impair offspring hippocampal neurocircuit formation and cognitive function, but underlying mechanisms driving…”
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Chondroitin sulfate glycan sulfation patterns influence histochemical labeling of perineuronal nets: a comparative study of interregional distribution in human and mouse brain by Belliveau, Claudia, Théberge, Stéphanie, Netto, Stefanie, Rahimian, Reza, Fakhfouri, Gohar, Hosdey, Clémentine, Davoli, Maria Antonietta, Hendrickson, Aarun, Hao, Kathryn, Giros, Bruno, Turecki, Gustavo, Alonge, Kimberly M, Mechawar, Naguib

“…Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form a net-like coverings around certain neurons in the brain. PNNs are primarily…”
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1527-P: Anorexia Induced by the Central Action of Fibroblast Growth Factor 1 (FGF1) Is Dependent on Reduced GABA Receptor Activation by SCARLETT, JARRAD M., ALONGE, KIMBERLY M., PHAN, BAO ANH N., MORTON, GREGORY J., SCHWARTZ, MICHAEL W.

“…Previously, we reported that in multiple rodent models of type 2 diabetes, remission of hyperglycemia lasting for weeks can be induced by a single…”
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Perineuronal net deglycosylation associates with tauopathy-induced gliosis and neurodegeneration by Logsdon, Aric F, Foresi, Brian, Hu, Shannon J, Quah, Emily, Meuret, Cristiana J, Le, Jaden P, Hendrickson, Aarun S, Redford, Ingrid K, Kumar, Asmit, Phan, Bao Anh, Doan, Tammy P, Noonan, Cassidy, Hendricks, Nzinga E, Wheeler, Jeanna M, Kraemer, Brian C, Alonge, Kimberly M

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by clinical symptoms of memory and cognitive deficiencies. Postmortem…”
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Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes by Alonge, Kimberly M., D’Alessio, David A., Schwartz, Michael W.

“…The authors wish to point out a typographical error…”
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Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity by Francis, Kendra L, Alonge, Kimberly M, Pacheco, Maria Cristina, Hu, Shannon J, Krutzsch, Cody A, Morton, Gregory J, Schwartz, Michael W, Scarlett, Jarrad M

“…The increased prevalence of inflammatory bowel disease (IBD) among patients with obesity and type 2 diabetes suggests a causal link between these diseases,…”
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