Search Results - "Alon, U."

Biological Networks: The Tinkerer as an Engineer by Alon, U.

“…This viewpoint comments on recent advances in understanding the design principles of biological networks. It highlights the surprising discovery of…”
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Structure and Function of the Feed-Forward Loop Network Motif by Mangan, S., Alon, U.

“…Engineered systems are often built of recurring circuit modules that carry out key functions. Transcription networks that regulate the responses of living…”
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Evolutionary Trade-Offs, Pareto Optimality, and the Geometry of Phenotype Space by Shoval, O., Sheftel, H., Shinar, G., Hart, Y., Ramote, O., Mayo, A., Dekel, E., Kavanagh, K., Alon, U.

“…Biological systems that perform multiple tasks face a fundamental trade-off: A given phenotype cannot be optimal at all tasks. Here we ask how trade-offs…”
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The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks by Mangan, S, Zaslaver, A, Alon, U

“…Recent analysis of the structure of transcription regulation networks revealed several "network motifs": regulatory circuit patterns that occur much more…”
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Network Motifs: Simple Building Blocks of Complex Networks by Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., Alon, U.

“…Complex networks are studied across many fields of science. To uncover their structural design principles, we defined "network motifs," patterns of…”
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Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs by Kashtan, N., Itzkovitz, S., Milo, R., Alon, U.

“…Biological and engineered networks have recently been shown to display network motifs: a small set of characteristic patterns that occur much more frequently…”
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Dynamic Proteomics of Individual Cancer Cells in Response to a Drug by Cohen, A.A, Geva-Zatorsky, N, Eden, E, Frenkel-Morgenstern, M, Issaeva, I, Sigal, A, Milo, R, Cohen-Saidon, C, Liron, Y, Kam, Z, Cohen, L, Danon, T, Perzov, N, Alon, U

“…Why do seemingly identical cells respond differently to a drug? To address this, we studied the dynamics and variability of the protein response of human…”
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The Incoherent Feed-forward Loop Accelerates the Response-time of the gal System of Escherichia coli by Mangan, S., Itzkovitz, S., Zaslaver, A., Alon, U.

“…Complex gene regulation networks are made of simple recurring gene circuits called network motifs. One of the most common network motifs is the incoherent…”
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Detailed Map of a Cis-Regulatory Input Function by Setty, Y., Mayo, A. E., Surette, M. G., Alon, U.

“…Most genes are regulated by multiple transcription factors that bind specific sites in DNA regulatory regions. These cis-regulatory regions perform a…”
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Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucleotide Arrays by Alon, U., Barkai, N., Notterman, D. A., Gish, K., Ybarra, S., Mack, D., Levine, A. J.

“…Oligonucleotide arrays can provide a broad picture of the state of the cell, by monitoring the expression level of thousands of genes at the same time. It is…”
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Robustness in bacterial chemotaxis by Leibler, S, Alon, U, Surette, M. G, Barkai, N

“…Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these…”
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Subgraphs in random networks by Itzkovitz, S, Milo, R, Kashtan, N, Ziv, G, Alon, U

“…Understanding the subgraph distribution in random networks is important for modeling complex systems. In classic Erdos networks, which exhibit a Poissonian…”
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Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays by NOTTERMAN, Daniel A, ALON, Uri, SIERK, Alexander J, LEVINE, Arnold J

“…Using an oligonucleotide array containing sequences complementary to approximately 3200 full-length human cDNAs and 3400 expressed sequence tags (GeneChip,…”
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Ordering Genes in a Flagella Pathway by Analysis of Expression Kinetics from Living Bacteria by Kalir, S., McClure, J., Pabbaraju, K., Southward, C., Ronen, M., Leibler, S., Surette, M. G., Alon, U.

“…The recent advances in large-scale monitoring of gene expression raise the challenge of mapping systems on the basis of kinetic expression data in living…”
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Measurement of urinary concentration : a critical appraisal of methodologies by CHADHA, Vimal, GARG, Uttam, ALON, Uri S

“…The measurement of urine concentration provides information concerning the kidney's ability to appropriately respond to variations in fluid homeostasis. It…”
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Power Laws and Similarity of Rayleigh-Taylor and Richtmyer-Meshkov Mixing Fronts at All Density Ratios by Alon, U, Hecht, J, Ofer, D, Shvarts, D

“…The nonlinear evolution of large structure in Rayleigh-Taylor and Richtmyer-Meshkov bubble and spike fronts is studied numerically and explained theoretically…”
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High incidence of focal segmental glomerulosclerosis in nephrotic syndrome of childhood by SRIVASTAVA, T, SIMON, S. D, ALON, U. S

“…In recent adult literature, there have been reports of an increasing incidence of focal segmental glomerulosclerosis (FSGS) among patients with nephrotic…”
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Response regulator output in bacterial chemotaxis by Alon, Uri, Camarena, Laura, Surette, Michael G., Aguera y Arcas, Blaise, Liu, Yi, Leibler, Stanislas, Stock, Jeffry B.

“…Chemotaxis responses in Escherichia coli are mediated by the phosphorylated response‐regulator protein P‐CheY. Biochemical and genetic studies have established…”
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Tumour heterogeneity and the evolutionary trade-offs of cancer by Hausser, Jean, Alon, Uri

“…Tumours vary in gene expression programmes and genetic alterations. Understanding this diversity and its biological meaning requires a theoretical framework,…”
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Study of Nonlinear Evolution of Single-Mode and Two-Bubble Interaction under Richtmyer-Meshkov Instability by Sadot, O., Erez, L., Alon, U., Oron, D., Levin, L. A., Erez, G., Ben-Dor, G., Shvarts, D.

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