Search Results - "Aloisi, Claudia"

Sequence-Specific Quantitation of Mutagenic DNA Damage via Polymerase Amplification with an Artificial Nucleotide by Aloisi, Claudia M. N, Nilforoushan, Arman, Ziegler, Nathalie, Sturla, Shana J

“…DNA mutations can result from replication errors due to different forms of DNA damage, including low-abundance DNA adducts induced by reactions with…”
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A Chemical Link between Meat Consumption and Colorectal Cancer Development? by Aloisi, Claudia M. N, Sandell, Emma S, Sturla, Shana J

“…O 6-carboxymethylguanine (O 6-CMG) is a mutagenic DNA adduct that forms at increased levels when people eat meat. It has been studied as a potential initiating…”
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DNA Adduct-Directed Synthetic Nucleosides by Räz, Michael H, Aloisi, Claudia M. N, Gahlon, Hailey L, Sturla, Shana J

“…Conspectus Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For…”
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Modulation of Cytotoxicity by Transcription-Coupled Nucleotide Excision Repair Is Independent of the Requirement for Bioactivation of Acylfulvene by Otto, Claudia, Spivak, Graciela, Aloisi, Claudia M.N, Menigatti, Mirco, Naegeli, Hanspeter, Hanawalt, Philip C, Tanasova, Marina, Sturla, Shana J

“…Bioactivation as well as DNA repair affects the susceptibility of cancer cells to the action of DNA-alkylating chemotherapeutic drugs. However, information is…”
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Mechanism of RNA polymerase II stalling by DNA alkylation by Malvezzi, Stefano, Farnung, Lucas, Aloisi, Claudia M. N., Angelov, Todor, Cramer, Patrick, Sturla, Shana J.

“…Several anticancer agents that form DNA adducts in the minor groove interfere with DNA replication and transcription to induce apoptosis. Therapeutic…”
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A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation by Aloisi, Claudia M.N., Escher, Nora A., Kim, Hyun Suk, Geisen, Susanne M., Fontana, Gabriele A., Yeo, Jung-Eun, Schärer, Orlando D., Sturla, Shana J.

“…Distinct cellular DNA damage repair pathways maintain the structural integrity of DNA and protect it from the mutagenic effects of genotoxic exposures and…”
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Direct Alkylation of Deoxyguanosine by Azaserine Leads to O 6‑Carboxymethyldeoxyguanosine by Geisen, Susanne M, Aloisi, Claudia M. N, Huber, Sabrina M, Sandell, Emma S, Escher, Nora A, Sturla, Shana J

“…The O 6-alkylguanosine adduct O 6-carboxymethyldeoxyguanosine (O 6-CMdG) has been detected at elevated levels in blood and tissue samples from colorectal…”
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The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS by Yan, Robert, Friemel, Martin, Aloisi, Claudia, Huynen, Martijn, Taylor, Ian A, Leimkühler, Silke, Pastore, Annalisa

“…The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of…”
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