Search Results - "Aloi, Macarena S"

Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures by Aloi, Macarena S, Prater, Katherine E, Sánchez, Raymond E A, Beck, Asad, Pathan, Jasmine L, Davidson, Stephanie, Wilson, Angela, Keene, C Dirk, de la Iglesia, Horacio, Jayadev, Suman, Garden, Gwenn A

“…Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid…”
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Recombinant adeno‐associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia by Su, Wei, Kang, John, Sopher, Bryce, Gillespie, James, Aloi, Macarena S., Odom, Guy L., Hopkins, Stephanie, Case, Amanda, Wang, David B., Chamberlain, Jeffrey S., Garden, Gwenn A.

“…Microglia are a specialized population of myeloid cells that mediate CNS innate immune responses. Efforts to identify the cellular and molecular mechanisms…”
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miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder by Aloi, Macarena S, Poblete, Guillermo F, Oldham, John, Patriquin, Michelle A, Nielsen, David A, Kosten, Thomas R, Salas, Ramiro

“…Borderline personality disorder (BPD) is characterized by patterns of unstable affect, unstable interpersonal relationships, and chronic suicidal tendencies…”
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MicroRNAs mediating CNS inflammation: Small regulators with powerful potential by Su, Wei, Aloi, Macarena S, Garden, Gwenn A

“…Highlights • Microglia behavior in influenced by microRNAs. • miR-155 is a major regulator of pro-inflammatory responses in microglia. • Activation of p53 in…”
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The pro‐inflammatory microRNA miR‐155 influences fibrillar β‐Amyloid1‐42 catabolism by microglia by Aloi, Macarena S., Prater, Katherine E., Sopher, Bryce, Davidson, Stephanie, Jayadev, Suman, Garden, Gwenn A.

“…Microglia are the innate immune cells of the central nervous system that adopt rapid functional changes in response to Damage Associated Molecular Patterns,…”
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Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice by Aloi, Macarena S, Thompson, Samantha J, Quartapella, Nicholas, Noebels, Jeffrey L

“…Mutations in Kv1.1 (Kcna1) voltage-gated potassium channels in humans and mice generate network hyperexcitability, enhancing aberrant postnatal neurogenesis in…”
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The pro-inflammatory microRNA miR-155 influences fibrillar β-Amyloid 1 -42 catabolism by microglia by Aloi, Macarena S, Prater, Katherine E, Sopher, Bryce, Davidson, Stephanie, Jayadev, Suman, Garden, Gwenn A

“…Microglia are the innate immune cells of the central nervous system that adopt rapid functional changes in response to Damage Associated Molecular Patterns,…”
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A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors by Prater, Katherine E, Aloi, Macarena S, Pathan, Jasmine L, Winston, Chloe N, Chernoff, Rachel A, Davidson, Stephanie, Sadgrove, Matthew, McDonough, Ashley, Zierath, Dannielle, Su, Wei, Weinstein, Jonathan R, Garden, Gwenn A

“…Microglia maintain brain health and play important roles in disease and injury. Despite the known ability of microglia to proliferate, the precise nature of…”
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The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation by Aloi, Macarena S, Su, Wei, Garden, Gwenn A

“…The tumor-suppressor protein p53 belongs to a family of proteins that play pivotal roles in multiple cellular functions including cell proliferation, cell…”
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Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice by Yang, Yue, Aloi, Macarena S, Cudaback, Eiron, Josephsen, Samuel R, Rice, Samantha J, Jorstad, Nikolas L, Keene, C Dirk, Montine, Thomas J

“…Frontotemporal dementia (FTD) is a neurodegenerative disease with devastating changes in behavioral performance and social function. Mutations in the…”
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Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-[beta] pathology but causes hyperexcitability and seizures by Aloi, Macarena S, Prater, Katherine E, Sánchez, Raymond E. A, Beck, Asad, Pathan, Jasmine L, Davidson, Stephanie, Wilson, Angela, Keene, C. Dirk, de la Iglesia, Horacio, Jayadev, Suman, Garden, Gwenn A

“…Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-[beta] (A[beta]) as well as CNS and systemic inflammation. Microglia,…”
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miR-155 Expression Modulates Microglia Functions in vitro and in the APP/PS1 Mouse Model of Alzheimer’s Disease by Aloi, Macarena S

“…Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular Amyloid-β (Aβ) as well as both CNS and systemic inflammation. Microglia, myeloid…”
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