Is extended-field concurrent chemoradiation an option for radiologic negative paraaortic lymph node, locally advanced cervical cancer?

Is extended-field concurrent chemoradiation an option for radiologic negative paraaortic lymph node, locally advanced cervical cancer?

The aim was to evaluate whether extended-field concurrent chemoradiation (EF-CCRT) leads to results better than those obtained by standard whole-pelvis concurrent chemoradiation (WP-CCRT) in locally advanced cervical cancer with radiologic negative paraaortic lymph nodes (PALNs). A total of 102 pati...

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Bibliographic Details
Published in:Cancer management and research Vol. 6; no. default; pp. 339 - 348
Main Authors: Asiri, Mushabbab Al, Tunio, Mutahir A, Mohamed, Reham, Bayoumi, Yasser, Alhadab, Abdulrehman, Saleh, Rasha M, AlArifi, Muhannad Saud, Alobaid, Abdelaziz
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2014
Taylor & Francis Ltd
Dove Press
Dove Medical Press
Subjects:
Abdomen
Antigens
Biopsy
Bladder
Cancer
Cancer therapies
Care and treatment
Cervical cancer
Chemotherapy
Complications and side effects
concurrent chemotherapy
Development and progression
Lymphatic diseases
Lymphatic system
Medical imaging
Metastasis
Methods
NMR
Nuclear magnetic resonance
Oncology
Original Research
Patient outcomes
Planning
prophylactic extended field radiation therapy
Radiation therapy
Radiotherapy
Surgery
Womens health
Saudi Arabia
Riyadh Saudi Arabia
Cairo Egypt
concurrent chemotherapy
prophylactic extended field radiation therapy
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Summary:The aim was to evaluate whether extended-field concurrent chemoradiation (EF-CCRT) leads to results better than those obtained by standard whole-pelvis concurrent chemoradiation (WP-CCRT) in locally advanced cervical cancer with radiologic negative paraaortic lymph nodes (PALNs). A total of 102 patients with histopathologically proven squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma, and radiologic negative PALN locally advanced cervical cancer, stage IIB-IVA, were accrued between July 2007 and April 2008 and were randomly assigned to WP-CCRT (50 patients) or EF-CCRT (52 patients), followed by high-dose rate brachytherapy. Data regarding the safety profile, response rates, and occurrence of local, PALN, or distant failure were recorded. During a median follow-up time of 60 months (18-66), 74/102 patients completed the treatment protocol and were analyzed. Overall PALN, distant-metastasis control, disease-free survival, and overall survival rates were 97.1%, 86.9%, 80.3%, and 72.4% in EF-CCRT respectively in comparison with WP-CCRT (82.1%,74.7%, 69.1%, and 60.4%), with P-values of 0.02, 0.03, 0.03 and 0.04 respectively. No difference in acute toxicity profile was seen between the groups, and late toxicities were mild and minimal. Prophylactic EF-CCRT can be a reasonable option in patients with locally advanced cervical cancer with radiologic positive pelvic lymph nodes and radiologic negative PALN.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S68262