Search Results - "Alnaes, G. G."

Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes by Nordgard, Silje H, Johansen, Fredrik E, Alnaes, Grethe I G, Naume, Bjørn, Børresen-Dale, Anne-Lise, Kristensen, Vessela N

“…Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to…”
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Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate by Jabeen, S, Holmboe, L, Alnæs, G I G, Andersen, A M, Hall, K S, Kristensen, V N

“…Osteosarcoma patients are commonly treated with high doses of methotrexate (MTX). MTX is an analog of folate, which is essential for DNA synthesis. Genetic…”
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Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients by Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela N, Kvaløy, Jan T, Lash, Timothy L, Alnæs, Grethe I G, van Schaik, Ron H, Janssen, Emiel A M, Hustad, Steinar, Lien, Ernst A, Mellgren, Gunnar, Søiland, Håvard

“…Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in…”
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Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN by Borge, Kaja S, Nord, Silje, Van Loo, Peter, Lingjærde, Ole C, Gunnes, Gjermund, Alnæs, Grethe I G, Solvang, Hiroko K, Lüders, Torben, Kristensen, Vessela N, Børresen-Dale, Anne-Lise, Lingaas, Frode

“…Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic…”
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Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients by Nordgard, Silje H., Johansen, Fredrik E., Alnæs, Grethe I. G., Bucher, Elmar, Syvänen, Ann-Christine, Naume, Bjørn, Børresen-Dale, Anne-Lise, Kristensen, Vessela N.

“…Breast carcinomas are characterized by DNA copy number alterations (CNAs) with biological and clinical significance. This explorative study integrated CNA,…”
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Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients by Vaclavikova, Radka, Nordgard, Silje H, Alnaes, Grethe I.G, Hubackova, Miluse, Kubala, Eugen, Kodet, Roman, Mrhalova, Marcela, Novotny, Jan, Gut, Ivan, Kristensen, Vessela N, Soucek, Pavel

“…OBJECTIVESResistance of tumor cells to multiple cytostatic agents is one of the major impediments of successful cancer chemotherapy. A large part of resistance…”
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Pathway based analysis of SNPs with relevance to 5‐FU therapy: Relation to intratumoral mRNA expression and survival by Nordgard, Silje H., Alnæs, Grethe I.G., Hihn, Björn, Lingjærde, Ole Christian, Liestøl, Knut, Tsalenko, Anya, Sørlie, Therese, Lønning, Per Eystein, Børresen‐Dale, Anne‐Lise, Kristensen, Vessela N.

“…Genetic factors are thought to play a role in resistance towards chemotherapeutic agents such as 5‐fluorouracil (5‐FU). Approximately 30 genes are directly or…”
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A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients by Seibold, Petra, Schmezer, Peter, Behrens, Sabine, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Flesch-Janys, Dieter, Nevanlinna, Heli, Fagerholm, Rainer, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Lambrechts, Diether, Wildiers, Hans, Kristensen, Vessela, Alnæs, Grethe Grenaker, Nord, Silje, Borresen-Dale, Anne-Lise, Hooning, Maartje J, Hollestelle, Antoinette, Jager, Agnes, Seynaeve, Caroline, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Dunning, Alison M, Rhenius, Valerie, Shah, Mitul, Kabisch, Maria, Torres, Diana, Ulmer, Hans-Ulrich, Hamann, Ute, Schildkraut, Joellen M, Purrington, Kristen S, Couch, Fergus J, Hall, Per, Pharoah, Paul, Easton, Doug F, Schmidt, Marjanka K, Chang-Claude, Jenny, Popanda, Odilia

“…Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments,…”
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ABCB1 and GST polymorphisms associated with TP53 status in breast cancer by Nordgard, Silje H, Ritchie, Marylyn D, Jensrud, Sigrid D, Motsinger, Alison A, Alnæs, Grethe I.G, Lemmon, Gordon, Berg, Marianne, Geisler, Stephanie, Moore, Jason H, Lønning, Per Eystein, Børresen-Dale, Anne-Lise, Kristensen, Vessela N

“…BACKGROUND AND OBJECTIVEMany environmental and genetic factors influence the development of chemoresistance. The goal of this study was to characterize the…”
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Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density by Biong, Margarethe, Gram, Inger T, Brill, Ilene, Johansen, Fredrik, Solvang, Hiroko K, Alnaes, Grethe I G, Fagerheim, Toril, Bremnes, Yngve, Chanock, Stephen J, Burdett, Laurie, Yeager, Meredith, Ursin, Giske, Kristensen, Vessela N

“…Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived…”
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Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma by Vaclavikova, Radka, Klajic, Jovana, Brynychova, Veronika, Elsnerova, Katerina, Alnaes, Grethe I G, Tost, Jörg, Kristensen, Vessela N, Rob, Lukas, Kodet, Roman, Skapa, Petr, Mrhalova, Marcela, Soucek, Pavel

“…Multidrug resistance to anticancer drugs, which is often associated with enhanced expression of the ATP‑binding cassette (ABC) transporter P‑glycoprotein…”
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Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk by VACHON, Celine M, SCOTT, Christopher G, JUD, Sebastian M, HEUSINGER, Katharina, BECKMANN, Matthias W, POLLAN, Marina, FERNANDEZ-NAVARRO, Pablo, GONZALEZ-NEIRA, Anna, BENITEZ, Javier, VAN GILS, Carla H, LOKATE, Mariëtte, ONLAND-MORET, N. Charlotte, FASCHING, Peter A, PEETERS, Petra H. M, BROWN, Judith, LEYLAND, Jean, VARGHESE, Jajini S, EASTON, Douglas F, THOMPSON, Deborah J, LUBEN, Robert N, WARREN, Ruth M. L, WAREHAM, Nicholas J, LOOS, Ruth J. F, HALL, Per, KHAW, Kay-Tee, URSIN, Giske, LEE, Eunjung, GAYTHER, Simon A, RAMUS, Susan J, EELES, Rosalind A, LEACH, Martin O, KWAN-LIM, Gek, COUCH, Fergus J, GILES, Graham G, TAMIMI, Rulla M, BAGLIETTO, Laura, KRISHNAN, Kavitha, SOUTHE, Melissa C, LE MARCHAND, Loic, KOLONEL, Laurence N, WOOLCOTT, Christy, MASKARINEC, Gertraud, HAIMAN, Christopher A, WALKER, Kate, JOHNSON, Nichola, JINGMEI LI, MCCORMACK, Valeria A, BIONG, Margarethe, ALNAES, Grethe I. G, GRAM, Ingertorhild, KRISTENSEN, Vessela N, BØRRESEN-DALE, Anne-Lise, LINDSTRÖM, Sara, HANKINSON, SusanE, HUNTER, David J, ANDRULIS, Irene L, STONE, Jennifer, APICELLA, Carmel, ODEFREY, Fabrice, GIERACH, Gretchen L

“…Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic…”
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Multiplex single-tube screening for mutations in the Nijmegen Breakage Syndrome ( ) gene in Hodgkin's and non-Hodgkin's lymphoma patients of Slavic origin by SOUCEK, Pavel, GUT, Ivan, TRNENY, Marek, SKOVLUND, Eva, ALNAES, Grethe Grenaker, KRISTENSEN, Tom, BØRRESEN-DALE, Anne-Lise, KRISTENSEN, Vessela N

“…Patients with Nijmegen Breakage Syndrome (NBS) have a high risk to develop malignant diseases, most frequently B-cell lymphomas. It has been demonstrated that…”
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Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21 by Hamdi, Yosr, Soucy, Penny, Adoue, Véronique, Michailidou, Kyriaki, Canisius, Sander, Lemaçon, Audrey, Droit, Arnaud, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Baynes, Caroline, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borresen-Dale, Anne-Lise, Brand, Judith S, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Chang-Claude, Jenny, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Dennis, Joe, Devilee, Peter, Dörk, Thilo, Dos-Santos-Silva, Isabel, Eriksson, Mikael, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, García-Closas, Montserrat, Giles, Graham G, Goldberg, Mark S, González-Neira, Anna, Grenaker-Alnæs, Grethe, Guénel, Pascal, Haeberle, Lothar, Haiman, Christopher A, Hamann, Ute, Hallberg, Emily, Hooning, Maartje J, Hopper, John L, Jakubowska, Anna, Jones, Michael, Kabisch, Maria, Kataja, Vesa, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Lubinski, Jan, Mannermaa, Arto, Maranian, Mel, Margolin, Sara, Marme, Frederik, Milne, Roger L, Neuhausen, Susan L, Nevanlinna, Heli, Neven, Patrick, Olswold, Curtis, Peto, Julian, Plaseska-Karanfilska, Dijana, Pylkäs, Katri, Radice, Paolo, Rudolph, Anja, Sawyer, Elinor J, Schmidt, Marjanka K, Shu, Xiao-Ou, Southey, Melissa C, Swerdlow, Anthony, Tollenaar, Rob A E M, Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine, Van Den Ouweland, Ans M W, Wang, Qin, Winqvist, Robert, Zheng, Wei, Benitez, Javier, Chenevix-Trench, Georgia, Dunning, Alison M, Pharoah, Paul D P, Kristensen, Vessela, Hall, Per, Easton, Douglas F, Pastinen, Tomi, Nord, Silje, Simard, Jacques

“…There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an…”
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GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas by Rønneberg, Jo Anders, Tost, Jörg, Solvang, Hiroko K, Alnaes, Grethe I G, Johansen, Fredrik E, Brendeford, Elen M, Yakhini, Zohar, Gut, Ivo G, Lønning, Per Eystein, Børresen-Dale, Anne-Lise, Gabrielsen, Odd S, Kristensen, Vessela N

“…The CpG island spanning the transcription start of the glutathione S-transferase P1 becomes methylated in a variety of human cancers including breast cancer…”
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Genetic polymorphisms in the 5' flanking region of glutathione S-transferase P1 affect promoter methylation by Rønneberg, JA, Tost, J, Grenaker-Alnæs, GI, Sørlie, T, Kristensen, T, Gut, I, Børresen-Dale, A-L, Kristensen, VN

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Chromosome-wide pharmacogenetics: localisation and linkage disequilibrium of genes coding for ROS metabolism and signalling by Edvardsen, H, Kulle, B, Grenaker-Alnaes, GI, Syvänen, AC, Barresen-Dale, AL, Frigessi, A, Kristensen, VN

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Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 by Orr, N., Dudbridge, F., Dryden, N., Maguire, S., Novo, D., Perrakis, E., Johnson, N., Ghoussaini, M., Hopper, J. L., Southey, M. C., Apicella, C., Stone, J., Schmidt, M. K., Broeks, A., Van't Veer, L. J., Hogervorst, F. B., Fasching, P. A., Haeberle, L., Ekici, A. B., Beckmann, M. W., Gibson, L., Aitken, Z., Warren, H., Sawyer, E., Tomlinson, I., Kerin, M. J., Miller, N., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Guenel, P., Truong, T., Cordina-Duverger, E., Sanchez, M., Bojesen, S. E., Nordestgaard, B. G., Nielsen, S. F., Flyger, H., Benitez, J., Zamora, M. P., Arias Perez, J. I., Menendez, P., Anton-Culver, H., Neuhausen, S. L., Brenner, H., Dieffenbach, A. K., Arndt, V., Stegmaier, C., Hamann, U., Brauch, H., Justenhoven, C., Bruning, T., Ko, Y.-D., Nevanlinna, H., Aittomaki, K., Blomqvist, C., Khan, S., Bogdanova, N., Dork, T., Lindblom, A., Margolin, S., Mannermaa, A., Kataja, V., Kosma, V.-M., Hartikainen, J. M., Chenevix-Trench, G., Beesley, J., Lambrechts, D., Moisse, M., Floris, G., Beuselinck, B., Chang-Claude, J., Rudolph, A., Seibold, P., Flesch-Janys, D., Radice, P., Peterlongo, P., Peissel, B., Pensotti, V., Couch, F. J., Olson, J. E., Slettedahl, S., Vachon, C., Giles, G. G., Milne, R. L., McLean, C., Haiman, C. A., Henderson, B. E., Schumacher, F., Le Marchand, L., Simard, J., Goldberg, M. S., Labreche, F., Dumont, M., Kristensen, V., Alnaes, G. G., Nord, S., Borresen-Dale, A.-L., Zheng, W.

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Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer by Grawenda, Anna M, Møller, Elen K, Lam, Suzanne, Repapi, Emmanouela, Teunisse, Amina F A S, Alnæs, Grethe I G, Børresen-Dale, Anne-Lise, Kristensen, Vessela N, Goding, Colin R, Jochemsen, Aart G, Edvardsen, Hege, Bond, Gareth L

“…TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are…”
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The role of ABCB1 transporter gene in breast cancer resistance by Vaclavikova, R, Nordgard, SH, Alnaes, GA, Hubackova, M, Hlavata, I, Kodet, R, Mrhalova, M, Pecha, V, Kristensen, VN, Gut, I, Soucek, P

“…Abstract Abstract #4158 Background: Cellular multidrug resistance (MDR) to anticancer drugs remains one of the primary causes of suboptimal outcomes in cancer…”
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